PANTHER - Family Information

PANTHER Family Information

Family:

QUEUINE TRNA-RIBOSYLTRANSFERASE (PTHR11962)

Subfamilies:

PANTHER Links:

Tree MSA

Abstract:

queuosine at position 34 in bacterial tRNAs and This is a family of queuine, archaeosine and general tRNA-ribosyltransferases EC: 2.4.2.29, also known as tRNA-guanine transglycosylase and guanine insertion enzyme. Queuine tRNA-ribosyltransferase modifies tRNAs for asparagine, aspartic acid, histidine and tyrosine with queuine at position 34 and with archaeosine at position 15 in archaeal tRNAs. In bacterial it catalyses the exchange of guanine-34 at the wobble position with 7-aminomethyl-7-deazaguanine, and the addition of a cyclopentenediol moiety to 7-aminomethyl-7-deazaguanine-34 tRNA; giving a hypermodified base queuine in the wobble position [PMID:8654383, PMID:8323579]. The aligned region contains a zinc binding motif C-x-C-x2-C-x29-H, and important tRNA and 7-aminomethyl-7deazaguanine binding residues [PMID:8654383].

InterPro Accession:

IPR002616

PANTHER Molecular Function:

Transferase

Glycosyltransferase

PANTHER Biological Process:

Nucleoside, nucleotide and nucleic acid metabolism

tRNA metabolism

Pathway Categories:

No pathway information available

Training Sequences:

HMM Length

500

Downloads:

HMM (HMMER format)

Genes assigned to this Family

	Total	Celera	FlyBase	NCBI
H. sapiens	4	2	0	2
M. musculus	4	2	0	2
R. norvegicus	4	2	0	2
D. melanogaster	2	0	2	0