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PANTHER Family Information   
Family: QUEUINE TRNA-RIBOSYLTRANSFERASE (PTHR11962)
Subfamilies: 1
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract: queuosine at position 34 in bacterial tRNAs and This is a family of queuine, archaeosine and general tRNA-ribosyltransferases EC: 2.4.2.29, also known as tRNA-guanine transglycosylase and guanine insertion enzyme. Queuine tRNA-ribosyltransferase modifies tRNAs for asparagine, aspartic acid, histidine and tyrosine with queuine at position 34 and with archaeosine at position 15 in archaeal tRNAs. In bacterial it catalyses the exchange of guanine-34 at the wobble position with 7-aminomethyl-7-deazaguanine, and the addition of a cyclopentenediol moiety to 7-aminomethyl-7-deazaguanine-34 tRNA; giving a hypermodified base queuine in the wobble position [PMID:8654383, PMID:8323579]. The aligned region contains a zinc binding motif C-x-C-x2-C-x29-H, and important tRNA and 7-aminomethyl-7deazaguanine binding residues [PMID:8654383].
InterPro Accession: IPR002616
PANTHER Molecular Function: Transferase
   Glycosyltransferase

PANTHER Biological Process: Nucleoside, nucleotide and nucleic acid metabolism
   tRNA metabolism

Pathway Categories: No pathway information available
Training Sequences: 40
HMM Length 500
Downloads: HMM (HMMER format)

Genes assigned to this Family
  Total Celera FlyBase NCBI
H. sapiens 4 2 0 2
M. musculus 4 2 0 2
R. norvegicus 4 2 0 2
D. melanogaster 2 0 2 0
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