PANTHER Gene Information

Gene Symbol(s):

PLAA

Organism:

Homo sapiens

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Gene Name:

Phospholipase A-2-activating protein

Gene ID:

HGNC:9043

Protein ID:

Q9Y263

Enhancers:

View enhancers for HUMAN|HGNC=9043|UniProtKB=Q9Y263

Genetic Variant Annotation:

Annoq

Persistent Id:

PTN002500448

Alternate Ids:

CHEMBL6114(ChEMBL)	224036344(GI)
ENSP00000380460(Ensembl_PRO)	617527(MIM)
PLAA(Symbol)	PLA2P(Synonym)
AK001642(EMBL)	ENST00000397292(Ensembl_TRS)
9373(GeneID)	HGNC:9043(HGNC)
ENSG00000137055(Ensembl)	BAD97264(EMBL-CDS)
Q9NVE9(AltAccession)	NP_001026859(refSeq)
PLAP_HUMAN(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	PHOSPHOLIPASE A-2-ACTIVATING PROTEIN (PTHR19849)
PANTHER Subfamily:	PHOSPHOLIPASE A-2-ACTIVATING PROTEIN (PTHR19849:SF0)
PANTHER GO-slim Molecular Function:	ubiquitin binding
PANTHER GO-slim Biological Process:	cellular homeostasis proteasome-mediated ubiquitin-dependent protein catabolic process
PANTHER GO-slim Cellular Component:	cytoplasm nucleus
PANTHER protein class:	ubiquitin-protein ligase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	protein binding, ubiquitin binding, phospholipase A2 activator activity
GO BP Complete:	positive regulation of prostaglandin biosynthetic process, positive regulation of dendrite extension, signal transduction, negative regulation of protein K63-linked ubiquitination, nervous system development, positive regulation of synaptic vesicle recycling, phospholipid metabolic process, inflammatory response, proteasome-mediated ubiquitin-dependent protein catabolic process, cellular response to lipopolysaccharide, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, ubiquitin recycling, macroautophagy, positive regulation of neuron migration
GO CC Complete:	nucleus, extracellular exosome, cytoplasm, synapse

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000020832.4\|UniProtKB=H2QX34	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000016635.3\|UniProtKB=G3RKG9	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000064752.1\|UniProtKB=F6VW58	Macaca mulatta	LDO
MOUSE\|MGI=MGI=104810\|UniProtKB=P27612	Mus musculus	LDO
RAT\|RGD=621245\|UniProtKB=P54319	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000013011.6\|UniProtKB=A7Z055	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000005126.5\|UniProtKB=A0A5G2R9S8	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000020120.4\|UniProtKB=F7CG24	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000023980.4\|UniProtKB=M3XEX0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845017393.1\|UniProtKB=A0A8I3RZW5	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000004155.4\|UniProtKB=A0A5F8GKJ6	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000028747.2\|UniProtKB=K7EFL1	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010006465.1\|UniProtKB=A0A8V0XVG5	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000017506.3\|UniProtKB=G1KU18	Anolis carolinensis	LDO
XENLA\|Gene=plaa\|UniProtKB=Q6GM65	Xenopus laevis	LDO
XENLA\|Gene=plaa.L\|UniProtKB=Q08B76	Xenopus laevis	O
XENLA\|Gene=plaa.S\|UniProtKB=A0A8J0U1A6	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1011438\|UniProtKB=B1H2I4	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000005124.2\|UniProtKB=A0A3B3HS25	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030826-13\|UniProtKB=Q7SXM2	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000011346.1\|UniProtKB=W5MZY9	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000008371.3\|UniProtKB=F7A1R5	Ciona intestinalis	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_60329\|UniProtKB=C3Y9Y1	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC590638\|UniProtKB=A0A7M7PQ58	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00007333\|UniProtKB=G5EES6	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG00972\|UniProtKB=A8WP74	Caenorhabditis briggsae	LDO
DROME\|FlyBase=FBgn0024314\|UniProtKB=Q9VPY2	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP008620\|UniProtKB=Q7Q8I1	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC001920\|UniProtKB=D6X170	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_308935\|UniProtKB=E9HAA6	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW008317\|UniProtKB=B7PWX1	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG67216\|UniProtKB=T1FYY2	helobdella robusta	LDO
TRIAD\|EnsemblGenome=TriadG21530\|UniProtKB=B3RNS1	Trichoplax adhaerens	LDO
YEAST\|SGD=S000001696\|UniProtKB=P36037	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AER448W\|UniProtKB=Q755S0	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000180586\|UniProtKB=A0A1D8PEM3	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_D11132g\|UniProtKB=Q6C9H6	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_07704\|UniProtKB=C8VDG7	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_5G08370\|UniProtKB=Q4WUG5	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU06483\|UniProtKB=Q7RYJ1	Neurospora crassa	O
NEUCR\|EnsemblGenome=NCU00880\|UniProtKB=Q7SFF1	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_00477\|UniProtKB=A7E5A3	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_08902\|UniProtKB=Q0UH62	Phaeosphaeria nodorum	O
PHANO\|EnsemblGenome=SNOG_03007\|UniProtKB=Q0UZ07	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC887.04c\|UniProtKB=O94289	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_00312\|UniProtKB=B6JVA5	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNL05350\|UniProtKB=Q5K8K4	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_05402\|UniProtKB=A0A0D1DPP0	Ustilago maydis	O
USTMA\|EnsemblGenome=UMAG_03309\|UniProtKB=A0A0D1DYL9	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_16005\|UniProtKB=E3L0M9	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_04684\|UniProtKB=E3K3S6	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_92353\|UniProtKB=F4PDJ2	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0291003\|UniProtKB=Q54F90	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_53053\|UniProtKB=F0ZAY7	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_24_1900\|UniProtKB=Q4QAE1	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb927.8.6330\|UniProtKB=Q57YN4	Trypanosoma brucei	LDO
TRIV3\|Gene_ORFName=TVAG_295540\|UniProtKB=A2F221	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_287800\|UniProtKB=A2ER47	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_358850\|UniProtKB=A2E888	Trichomonas vaginalis	LDO
PLAF7\|Gene_ORFName=PF3D7_1363400\|UniProtKB=A0A5K1K8W0	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00031479001\|UniProtKB=A0BRT1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00001030001\|UniProtKB=A0CKJ9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00022458001\|UniProtKB=A0E1X0	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00023919001\|UniProtKB=A0E7C4	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00016197001\|UniProtKB=A0DE88	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00034419001\|UniProtKB=A0C2C5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00036315001\|UniProtKB=A0C8R3	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_22319\|UniProtKB=B8BZP4	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GZ16_PHYRM\|UniProtKB=H3GZ16	Phytophthora ramorum	O
PHYRM\|Gene=H3GC46_PHYRM\|UniProtKB=H3GC46	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_09g389912v5\|UniProtKB=A0A2K3DE20	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00059p00150840\|UniProtKB=U5D857	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_114G00160\|UniProtKB=A0A0K9Q2J4	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma05_g01800\|UniProtKB=A0A804IZT1	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_029023mg\|UniProtKB=K3ZQZ3	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3002G020700\|UniProtKB=C5X8N9	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb299230\|UniProtKB=A0A804Q6Q6	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os07g0123700\|UniProtKB=A0A0P0X1Z2	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_1g57450v3\|UniProtKB=I1H3R1	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0154580\|UniProtKB=A0A8I6WKG3	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS2D02G257400\|UniProtKB=W5C2F4	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS5A02G196100\|UniProtKB=A0A3B6KI12	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2A02G266700\|UniProtKB=A0A3B6AYF7	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2B02G275700\|UniProtKB=A0A3B6C5J8	Triticum aestivum	O
NELNU\|Gene_ORFName=HUJ06_014956\|UniProtKB=A0A1U7ZNR4	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110806240\|UniProtKB=A0A9R0JIE7	Spinacia oleracea	LDO
HELAN\|Gene_ORFName=HanXRQr2_Chr03g0110151\|UniProtKB=A0A9K3NVQ4	Helianthus annuus	LDO
HELAN\|Gene_ORFName=HannXRQ_Chr08g0216571\|UniProtKB=A0A251U3W2	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C900499800\|UniProtKB=A0A9R1UE31	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a001969mg\|UniProtKB=A0A022RBP4	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_31793\|UniProtKB=A0A1U8E7C4	Capsicum annuum	LDO
SOLLC\|EnsemblGenome=Solyc01g109350.3\|UniProtKB=A0A3Q7FDJ7	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107765477\|UniProtKB=A0A1S3XIW5	Nicotiana tabacum	O
TOBAC\|Gene=LOC107760255\|UniProtKB=A0A1S3X241	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi03g00371\|UniProtKB=D7TPX5	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_I01243\|UniProtKB=A0A059API2	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=GSBRNA2T00033643001\|UniProtKB=A0A078J4V7	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra022366\|UniProtKB=M4E0R9	Brassica campestris	O
BRACM\|EnsemblGenome=Bra001726\|UniProtKB=M4CBZ6	Brassica campestris	LDO
ARATH\|TAIR=locus=2087921\|UniProtKB=F4J9W8	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107898757\|UniProtKB=A0A1U8INS4	Gossypium hirsutum	O
GOSHI\|Gene=LOC107945161\|UniProtKB=A0A1U8N9Q8	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_007281\|UniProtKB=A0A061E0I9	Theobroma cacao	LDO
POPTR\|EnsemblGenome=POPTR_004G150700v3\|UniProtKB=B9H0M4	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_009G112100v3\|UniProtKB=B9HRR9	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_17G099000\|UniProtKB=A0A251JBG8	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0938150\|UniProtKB=B9RZC7	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_11G120700\|UniProtKB=I1LJG9	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_12G045800\|UniProtKB=I1LQ62	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_4g069090\|UniProtKB=A0A072UM09	Medicago truncatula	LDO
JUGRE\|Gene=LOC109020166\|UniProtKB=A0A6P9EBD3	Juglans regia	LDO
PRUPE\|EnsemblGenome=PRUPE_8G104600\|UniProtKB=M5VPY8	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_98884\|UniProtKB=D8RQJ0	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_175818\|UniProtKB=D8S0B2	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c13_21390\|UniProtKB=A0A2K1JMQ7	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0131s0025\|UniProtKB=A0A2R6W862	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_003470100\|UniProtKB=A0A1Y1I9W2	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_008420030\|UniProtKB=A0A1Y1IU74	Klebsormidium nitens	LDO