PANTHER Gene Information   
Gene Symbol(s): FBXW11
Organism: Homo sapiens
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Gene Name: F-box_WD repeat-containing protein 11
Gene ID: HGNC:13607
Protein ID: Q9UKB1
Enhancers: View enhancers for HUMAN|HGNC=13607|UniProtKB=Q9UKB1
Genetic Variant Annotation: Annoq
Persistent Id: PTN002542103
Alternate Ids:
F-box/WD repeat-containing protein 1B(Synonym) AB033280(EMBL)
6164757(GI) 605651(MIM)
BAG37495(EMBL-CDS) ENSG00000072803(Ensembl)
23291(GeneID) HGNC:13607(HGNC)
Q9Y4C6(AltAccession) FBXW11{ECO:0000303|PubMed:26837067,ECO:0000312|HGNC:HGNC:13607}(Symbol)
FBW1B_HUMAN(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: WD REPEAT-CONTAINING PROTEIN POP1 (PTHR44129)
PANTHER Subfamily: F-BOX_WD REPEAT-CONTAINING PROTEIN 11 (PTHR44129:SF4)  
PANTHER GO-slim Molecular Function: microtubule plus-end binding
dynein complex binding
PANTHER GO-slim Biological Process: nuclear migration
germ cell development
microtubule organizing center organization
brain development
axo-dendritic transport
vesicle transport along microtubule
animal organ morphogenesis
establishment of mitotic spindle orientation
PANTHER GO-slim Cellular Component: cytoplasmic microtubule
nuclear envelope
neuronal cell body
microtubule associated complex
neuron projection
kinetochore
PANTHER protein class:
Pathway Categories: Wnt signaling pathway
   betaTransducin repeat-containing protein
Hedgehog signaling pathway
   Slimb
Parkinson disease
   F-box and WD-40 domain protein 7
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein binding, microtubule plus-end binding, ubiquitin-like ligase-substrate adaptor activity, protein dimerization activity, dynein complex binding
GO BP Complete: germ cell development, protein polyubiquitination, protein dephosphorylation, nuclear migration, positive regulation of canonical NF-kappaB signal transduction, brain morphogenesis, positive regulation of proteolysis, positive regulation of circadian rhythm, protein destabilization, establishment of mitotic spindle orientation, proteasome-mediated ubiquitin-dependent protein catabolic process, rhythmic process, positive regulation of DNA-templated transcription, vesicle transport along microtubule, Wnt signaling pathway, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, microtubule organizing center organization, retrograde axonal transport, protein ubiquitination
GO CC Complete: axon cytoplasm, kinetochore, cytoplasmic microtubule, neuronal cell body, neuron projection, microtubule associated complex, nuclear envelope, nucleus, centrosome, ubiquitin ligase complex, cytoplasm, cytosol, SCF ubiquitin ligase complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Regulation of PLK1 Activity at G2/M Transition, Toll Like Receptor 2 (TLR2) Cascade, Fc epsilon receptor (FCERI) signaling, Cell Cycle, Mitotic, MAP kinase activation, Interleukin-1 family signaling, G2/M Transition, Signaling by Interleukins, MAP3K8 (TPL2)-dependent MAPK1/3 activation, Toll Like Receptor 3 (TLR3) Cascade, Post-translational protein modification, Toll Like Receptor 10 (TLR10) Cascade, CLEC7A (Dectin-1) signaling, Toll Like Receptor 7/8 (TLR7/8) Cascade, Dectin-1 mediated noncanonical NF-kB signaling, TCR signaling, Innate Immune System, Downstream TCR signaling, TNFR2 non-canonical NF-kB pathway, MyD88-independent TLR4 cascade , Toll Like Receptor TLR6:TLR2 Cascade, Activation of NF-kappaB in B cells, Interleukin-1 signaling, Metabolism of proteins, TRIF(TICAM1)-mediated TLR4 signaling , NIK-->noncanonical NF-kB signaling, Cell Cycle, FCERI mediated NF-kB activation, Toll Like Receptor 5 (TLR5) Cascade, Neddylation, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, C-type lectin receptors (CLRs), Toll Like Receptor 4 (TLR4) Cascade, Downstream signaling events of B Cell Receptor (BCR), Toll-like Receptor Cascades, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Toll Like Receptor 9 (TLR9) Cascade, Signaling by the B Cell Receptor (BCR), Cytokine Signaling in Immune system, Toll Like Receptor TLR1:TLR2 Cascade, Immune System, MyD88 cascade initiated on plasma membrane, Adaptive Immune System, MyD88 dependent cascade initiated on endosome, Antigen processing: Ubiquitination & Proteasome degradation, Mitotic G2-G2/M phases, Interleukin-17 signaling, Class I MHC mediated antigen processing & presentation

Orthologs