PANTHER Gene Information

Gene Symbol(s):

AFP

Organism:

Homo sapiens

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Gene Name:

Alpha-fetoprotein

Gene ID:

HGNC:317

Protein ID:

P02771

Enhancers:

View enhancers for HUMAN|HGNC=317|UniProtKB=P02771

Genetic Variant Annotation:

Annoq

Persistent Id:

PTN002478566

Alternate Ids:

31351(GI)	ENSG00000081051(Ensembl)
B2RBU3(AltAccession)	NM_001134(refSeq)
174(GeneID)	FETA_HUMAN(UniProtKB-ID)
ENSP00000379138(Ensembl_PRO)	HGNC:317(HGNC)
CHEMBL3712864(ChEMBL)	615970(MIM)
AFP(Symbol)	FETA(Synonym)
M10949(EMBL)	ENST00000395792(Ensembl_TRS)
AAH27881(EMBL-CDS)
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PANTHER Classification

PANTHER Family:	SERUM ALBUMIN-RELATED (PTHR11385)
PANTHER Subfamily:	ALPHA-FETOPROTEIN (PTHR11385:SF7)
PANTHER GO-slim Molecular Function:	small molecule binding
PANTHER GO-slim Biological Process:	transport
PANTHER GO-slim Cellular Component:	extracellular space cytoplasm
PANTHER protein class:	transfer/carrier protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	protein binding, metal ion binding
GO BP Complete:	ovulation from ovarian follicle, progesterone metabolic process, immune response, homeostasis of number of cells, apoptotic process, sexual reproduction
GO CC Complete:	endoplasmic reticulum lumen, extracellular space, cytoplasm, extracellular region

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Metabolism of proteins, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Post-translational protein phosphorylation, Post-translational protein modification

Orthologs

ID	Organism	Type
PANTR\|Gene=AFP\|UniProtKB=Q28789	Pan troglodytes	O
PANTR\|Ensembl=ENSPTRG00000016151.3\|UniProtKB=H2QPM9	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000008625.3\|UniProtKB=G3RRF4	Gorilla gorilla gorilla	O
GORGO\|Gene=AFP\|UniProtKB=P28050	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000003830.4\|UniProtKB=A0A1D5QKX9	Macaca mulatta	LDO
MOUSE\|MGI=MGI=87951\|UniProtKB=P02772	Mus musculus	LDO
RAT\|RGD=2065\|UniProtKB=P02773	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000017131\|UniProtKB=Q3SZ57	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000008949\|UniProtKB=Q8MJ76	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000023229\|UniProtKB=P49066	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000029224.4\|UniProtKB=M3X557	Felis catus	LDO
CANLF\|Gene=AFP\|UniProtKB=Q8MJU5	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845005947.1\|UniProtKB=A0A8I3N1E6	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000025520.3\|UniProtKB=F6VJ19	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000006907.4\|UniProtKB=F7B1W2	Ornithorhynchus anatinus	O
CHICK\|Gene=ALB\|UniProtKB=P19121	Gallus gallus	O
CHICK\|Gene=AFP\|UniProtKB=P84407	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010005094.1\|UniProtKB=A0A8V0XLL7	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010005070.1\|UniProtKB=A0A8V0XJ14	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000027678.2\|UniProtKB=H9GU02	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000010772.4\|UniProtKB=A0A803TJY3	Anolis carolinensis	O
XENLA\|Gene=LOC121403141\|UniProtKB=A0A1L8HVA3	Xenopus laevis	O
XENTR\|Gene=LOC101732943\|UniProtKB=A0A8J0SB78	Xenopus tropicalis	O
XENLA\|Gene=LOC108711114\|UniProtKB=A0A8J1N0E0	Xenopus laevis	O
XENTR\|Gene=LOC101732409\|UniProtKB=A0A8J0R0N3	Xenopus tropicalis	O
XENLA\|Gene=alb-a\|UniProtKB=P08759	Xenopus laevis	O
XENLA\|Gene=alb.S\|UniProtKB=Q642P7	Xenopus laevis	O
XENLA\|Gene=alb.L\|UniProtKB=A3KMU4	Xenopus laevis	O
XENLA\|Gene=alb-b\|UniProtKB=P14872	Xenopus laevis	O
XENLA\|Gene=LOC100189571\|UniProtKB=A0A8J1M9V2	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-480330\|UniProtKB=Q5CZZ1	Xenopus tropicalis	O
LEPOC\|Ensembl=ENSLOCG00000011330.1\|UniProtKB=W5MZW6	lepisosteus oculatus	O