PANTHER Gene Information   
Gene Symbol(s): Chrna7
Organism: Mus musculus
View Gene in Tree
Tree Reduced Tree  
Tree Reduced Tree
Gene Name: Neuronal acetylcholine receptor subunit alpha-7
Gene ID: MGI:99779
Protein ID: P49582
Persistent Id: PTN000435451
Alternate Ids:
ENSMUST00000032738(Ensembl_TRS) Acra7(Synonym)
L37663(EMBL) AAC42053(EMBL-CDS)
790854(GI) ENSMUSG00000030525(Ensembl)
ACHA7_MOUSE(UniProtKB-ID) NP_031416(refSeq)
11441(GeneID) MGI:99779(MGI)
CHEMBL3365(ChEMBL) ENSMUSP00000032738(Ensembl_PRO)
Chrna7(Symbol)
Show All

PANTHER Classification
PANTHER Family: NEUROTRANSMITTER GATED ION CHANNEL (PTHR18945)
PANTHER Subfamily: NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7 (PTHR18945:SF907)  
PANTHER GO-slim Molecular Function: excitatory extracellular ligand-gated monoatomic ion channel activity
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
PANTHER GO-slim Biological Process: regulation of membrane potential
chemical synaptic transmission
monoatomic ion transmembrane transport
PANTHER GO-slim Cellular Component: synapse
neuron projection
monoatomic ion channel complex
plasma membrane signaling receptor complex
PANTHER protein class: ligand-gated ion channel
Pathway Categories: Nicotinic acetylcholine receptor signaling pathway
   nicotinic acetylcholine receptor alpha
Alzheimer disease-amyloid secretase pathway
   alpha7 nicotinic acetylcholine receptor
Nicotinic acetylcholine receptor signaling pathway
   Nicotinic Acetylcholine Receptor

GO MF Complete: toxic substance binding, protein kinase binding, acetylcholine receptor activity, protein homodimerization activity, acetylcholine-gated monoatomic cation-selective channel activity, acetylcholine binding, adenylate cyclase binding, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential, amyloid-beta binding, monoatomic ion channel activity, chloride channel regulator activity, scaffold protein binding, transmembrane signaling receptor activity, protein binding, ATPase binding
GO BP Complete: response to food, response to acetylcholine, negative regulation of interleukin-1 beta production, regulation of norepinephrine secretion, negative regulation of cytokine production involved in inflammatory response, activation of protein kinase C activity, associative learning, memory, ovulation cycle, learning or memory, positive regulation of protein metabolic process, positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure, acetylcholine receptor signaling pathway, modulation of excitatory postsynaptic potential, tumor necrosis factor production, establishment of localization in cell, negative regulation of tumor necrosis factor production, excitatory postsynaptic potential, generation of ovulation cycle rhythm, synapse organization, monoatomic ion transmembrane transport, negative regulation of inflammatory response, chemical synaptic transmission, dendritic spine organization, positive regulation of amyloid-beta formation, endocytosis, negative regulation of interleukin-6 production, regulation of membrane potential, regulation of amyloid fibril formation, positive regulation of gene expression, regulation of inflammatory response, modulation of chemical synaptic transmission, interleukin-6 production, synaptic transmission, cholinergic, positive regulation of long-term synaptic potentiation, T cell activation, B cell activation, negative regulation of canonical NF-kappaB signal transduction, presynaptic modulation of chemical synaptic transmission, response to cold, response to ethanol, monoatomic ion transport, sensory processing, calcium ion transport, dendrite arborization, regulation of response to drug, regulation of synapse structural plasticity, regulation of synaptic transmission, dopaminergic, neuronal action potential, behavioral response to nicotine, response to amyloid-beta, response to nicotine, behavioral response to ethanol, flagellated sperm motility, negative regulation of ERK1 and ERK2 cascade, positive regulation of ERK1 and ERK2 cascade, positive regulation of excitatory postsynaptic potential, interleukin-1 beta production
GO CC Complete: presynaptic membrane, external side of plasma membrane, acetylcholine-gated channel complex, neuronal cell body, synapse, neuron projection, plasma membrane raft, plasma membrane, glycinergic synapse, growth cone, dendrite, presynapse, cholinergic synapse, postsynaptic membrane, dendritic shaft, membrane, dendritic spine, spine apparatus membrane, postsynaptic specialization membrane, asymmetric synapse, axolemma, apical plasma membrane, axon
Reactome Pathways: Highly calcium permeable postsynaptic nicotinic acetylcholine receptors, Transmission across Chemical Synapses, Neuronal System, Postsynaptic nicotinic acetylcholine receptors, Acetylcholine binding and downstream events, Neurotransmitter receptors and postsynaptic signal transmission