PANTHER Gene Information

Gene Symbol(s):

Uros

Organism:

Mus musculus

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Gene Name:

Uroporphyrinogen-III synthase

Gene ID:

MGI:98917

Protein ID:

P51163

Persistent Id:

PTN000273392

Alternate Ids:

568950119(GI)	ENSMUSG00000030979(Ensembl)
HEM4_MOUSE(UniProtKB-ID)	MGI:98917(MGI)
4.2.1.75 {ECO:0000305\|PubMed:7607680}(EC)	NP_033505(refSeq)
ENSMUSP00000033276(Ensembl_PRO)	22276(GeneID)
Uros(Symbol)	Uros3(Synonym)
U04439(EMBL)	ENSMUST00000106146(Ensembl_TRS)
AAA79978(EMBL-CDS)
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PANTHER Classification

PANTHER Family:	UROPORPHYRINOGEN III SYNTHASE (PTHR12390)
PANTHER Subfamily:	UROPORPHYRINOGEN-III SYNTHASE (PTHR12390:SF0)
PANTHER GO-slim Molecular Function:	hydro-lyase activity
PANTHER GO-slim Biological Process:	aromatic compound biosynthetic process carboxylic acid biosynthetic process organonitrogen compound biosynthetic process porphyrin-containing compound metabolic process cellular nitrogen compound biosynthetic process heterocycle biosynthetic process organic cyclic compound biosynthetic process
PANTHER GO-slim Cellular Component:	cytosol
PANTHER protein class:	hydrolase

Pathway Categories:

Heme biosynthesis

Uroporphyrinogen-III synthase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	folic acid binding, uroporphyrinogen-III synthase activity
GO BP Complete:	heme O biosynthetic process, porphyrin-containing compound biosynthetic process, uroporphyrinogen III biosynthetic process, response to platinum ion, cellular response to arsenic-containing substance, heme biosynthetic process, heme A biosynthetic process, protoporphyrinogen IX biosynthetic process, cellular response to amine stimulus, heme B biosynthetic process
GO CC Complete:	mitochondrion, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Heme biosynthesis, Metabolism of porphyrins, Metabolism

Orthologs

ID	Organism	Type
HUMAN\|HGNC=12592\|UniProtKB=P10746	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000003042.7\|UniProtKB=H2Q2R3	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000011415.3\|UniProtKB=G3R707	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000008539.4\|UniProtKB=F7ERY4	Macaca mulatta	LDO
RAT\|RGD=1310396\|UniProtKB=Q5XIF2	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000005791.6\|UniProtKB=F6QDV4	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000010742.5\|UniProtKB=I3LT93	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000017285.4\|UniProtKB=A0A9L0T0X5	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000009550.6\|UniProtKB=A0A5F5Y1J7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845026709.1\|UniProtKB=A0A8I3PZ86	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000010434.4\|UniProtKB=F6YTJ9	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000042305.1\|UniProtKB=A0A6I8MX41	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010002466.1\|UniProtKB=E1BUH1	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000000920.4\|UniProtKB=G1K8Y2	Anolis carolinensis	LDO
XENLA\|Gene=uros.S\|UniProtKB=A0A1L8FED8	Xenopus laevis	O
XENLA\|Gene=uros.L\|UniProtKB=A0A8J0T9I5	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-999530\|UniProtKB=A0A803KIB4	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000009747.2\|UniProtKB=H2M1E5	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040323-2\|UniProtKB=Q568K6	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000007886.1\|UniProtKB=W5MMG7	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000009611.3\|UniProtKB=F7AD29	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118415031\|UniProtKB=A0A9J7MP45	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC115918631\|UniProtKB=A0A7M7NVR0	Strongylocentrotus purpuratus	LDO
STRPU\|EnsemblGenome=LOC586365\|UniProtKB=A0A7M7NV99	Strongylocentrotus purpuratus	LDO
DROME\|FlyBase=FBgn0038361\|UniProtKB=Q9VF38	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0030066\|UniProtKB=Q9W3B3	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP008064\|UniProtKB=A0A1S4GXX7	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC012334\|UniProtKB=D6X1Q8	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_44826\|UniProtKB=E9G2V3	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG164780\|UniProtKB=T1EVT1	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g204353\|UniProtKB=A7RZ79	Nematostella vectensis	LDO
YEAST\|SGD=S000005804\|UniProtKB=P06174	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AER351W\|UniProtKB=Q756B6	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000185290\|UniProtKB=A0A1D8PIS5	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_F09449g\|UniProtKB=Q6C2A4	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_10455\|UniProtKB=C8V7D2	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_6G12800\|UniProtKB=Q4WLP4	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU02395\|UniProtKB=Q7S4P0	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_11134\|UniProtKB=A7F0L6	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_03095\|UniProtKB=Q0UYR9	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC31G5.08\|UniProtKB=P87214	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_05283\|UniProtKB=B6K1J4	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNK02510\|UniProtKB=Q5K9B7	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_04126\|UniProtKB=A0A0D1C1A1	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_05631\|UniProtKB=E3K4Z5	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_84835\|UniProtKB=F4NVL3	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0285009\|UniProtKB=Q54NS4	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_156706\|UniProtKB=F0ZX77	Dictyostelium purpureum	LDO
PHYRM\|Gene=H3GT07_PHYRM\|UniProtKB=H3GT07	Phytophthora ramorum	LDO