PANTHER Gene Information   
Gene Symbol(s): Uba52
Organism: Mus musculus
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Gene Name: Ubiquitin-ribosomal protein eL40 fusion protein
Gene ID: MGI:98887
Protein ID: P62984
Persistent Id: PTN000071641
Alternate Ids:
22186(GeneID) NP_001335158(refSeq)
ENSMUST00000140679(Ensembl_TRS) ENSMUSP00000137461(Ensembl_PRO)
AF118402(EMBL) RL40(Synonym)
ENSMUSG00000068240(Ensembl) AAH54413(EMBL-CDS)
MGI:98887(MGI) 51701732(GI)
Q62317(AltAccession) RL40_MOUSE(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: UBIQUITIN (PTHR10666)
PANTHER Subfamily: UBIQUITIN-RIBOSOMAL PROTEIN ES31 FUSION PROTEIN (PTHR10666:SF442)  
PANTHER GO-slim Molecular Function: ubiquitin protein ligase binding
RNA binding
structural constituent of ribosome
PANTHER GO-slim Biological Process: modification-dependent protein catabolic process
protein ubiquitination
PANTHER GO-slim Cellular Component: cytosolic small ribosomal subunit
nucleus
PANTHER protein class:
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ubiquitin protein ligase binding, structural constituent of ribosome, protein tag activity
GO BP Complete: cytoplasmic translation, translation at presynapse, modification-dependent protein catabolic process, translation at postsynapse, protein ubiquitination
GO CC Complete: myelin sheath, cytosolic ribosome, endoplasmic reticulum, cytosolic large ribosomal subunit, synapse, ribosome, intracellular anatomical structure, plasma membrane, nucleoplasm, nucleus, presynapse, postsynapse, cytoplasm, cytosol
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Signaling by MET, Metabolism of RNA, Alpha-protein kinase 1 signaling pathway, Negative regulation of MET activity, Cell death signalling via NRAGE, NRIF and NADE, Membrane Trafficking, Interferon alpha/beta signaling, Gene expression (Transcription), Regulation of NF-kappa B signaling, GLI3 is processed to GLI3R by the proteasome, NRIF signals cell death from the nucleus, Hedgehog 'off' state, Signaling by NOTCH3, Regulation of APC/C activators between G1/S and early anaphase, TNFR2 non-canonical NF-kB pathway, Regulation of expression of SLITs and ROBOs, Signaling by WNT, APC/C:Cdc20 mediated degradation of mitotic proteins, Processing of DNA double-strand break ends, Signal Transduction, DNA Double Strand Break Response, Metalloprotease DUBs, Regulation of TP53 Activity through Methylation, Degradation of GLI1 by the proteasome, CDK-mediated phosphorylation and removal of Cdc6, TAK1-dependent IKK and NF-kappa-B activation , TRAF6-mediated induction of TAK1 complex within TLR4 complex, Toll Like Receptor 2 (TLR2) Cascade, Mitotic G2-G2/M phases, Regulation of mitotic cell cycle, Mitotic G1 phase and G1/S transition, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, SCF-beta-TrCP mediated degradation of Emi1, Regulation of PLK1 Activity at G2/M Transition, Cell Cycle, Regulation of TP53 Degradation, Downregulation of TGF-beta receptor signaling, Regulation of TNFR1 signaling, TGF-beta receptor signaling activates SMADs, Ubiquitin-dependent degradation of Cyclin D, Post-translational protein modification, Regulation of RUNX3 expression and activity, AUF1 (hnRNP D0) binds and destabilizes mRNA, Transport of small molecules, Iron uptake and transport, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, ABC-family proteins mediated transport, Degradation of beta-catenin by the destruction complex, Cytosolic sensors of pathogen-associated DNA , Activation of NF-kappaB in B cells, Downregulation of SMAD2/3:SMAD4 transcriptional activity, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Cyclin D associated events in G1, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), G1 Phase, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Regulation of mRNA stability by proteins that bind AU-rich elements, p75NTR recruits signalling complexes, Transcriptional regulation by RUNX1, Signaling by FGFR, PCP/CE pathway, Pexophagy, Developmental Biology, Orc1 removal from chromatin, Signaling by ERBB2, MyD88-independent TLR4 cascade , Signaling by CSF3 (G-CSF), Negative regulators of DDX58/IFIH1 signaling, Synthesis of DNA, Transcriptional regulation by RUNX3, Programmed Cell Death, C-type lectin receptors (CLRs), Transcriptional regulation by RUNX2, S Phase, DNA Replication Pre-Initiation, Cargo recognition for clathrin-mediated endocytosis, activated TAK1 mediates p38 MAPK activation, Clathrin-mediated endocytosis, Translation, Translesion Synthesis by POLH, G2/M Checkpoints, p75NTR signals via NF-kB, RNA Polymerase II Transcription, Cellular responses to stimuli, Signaling by EGFR, Toll-like Receptor Cascades, NOTCH3 Activation and Transmission of Signal to the Nucleus, Activated NOTCH1 Transmits Signal to the Nucleus, KEAP1-NFE2L2 pathway, Interleukin-17 signaling, Homology Directed Repair, G1/S Transition, Signaling by Hedgehog, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, DNA Double-Strand Break Repair, The role of GTSE1 in G2/M progression after G2 checkpoint, RAF/MAP kinase cascade, NF-kB is activated and signals survival, Hedgehog ligand biogenesis, Oncogene Induced Senescence, Autophagy, Cellular Senescence, Cap-dependent Translation Initiation, Negative regulation of FGFR2 signaling, Senescence-Associated Secretory Phenotype (SASP), Negative regulation of FGFR1 signaling, Oxidative Stress Induced Senescence, Mitophagy, Eukaryotic Translation Initiation, Endosomal Sorting Complex Required For Transport (ESCRT), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, MyD88 dependent cascade initiated on endosome, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Deactivation of the beta-catenin transactivating complex, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), EGFR downregulation, Fc epsilon receptor (FCERI) signaling, Selective autophagy, Cytokine Signaling in Immune system, Signaling by TGF-beta Receptor Complex, Adaptive Immune System, Asymmetric localization of PCP proteins, MAP3K8 (TPL2)-dependent MAPK1/3 activation, MAPK family signaling cascades, p53-Dependent G1/S DNA damage checkpoint, Toll Like Receptor 4 (TLR4) Cascade, DNA Replication, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, ER Quality Control Compartment (ERQC), Protein ubiquitination, Signaling by FGFR4, MAP kinase activation, Autodegradation of Cdh1 by Cdh1:APC/C, TNFR1-induced NF-kappa-B signaling pathway, Signaling by FGFR3, Interleukin-1 signaling, Regulation of TP53 Activity, Vesicle-mediated transport, p75 NTR receptor-mediated signalling, E3 ubiquitin ligases ubiquitinate target proteins, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, RAS processing, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Spry regulation of FGF signaling, PINK1-PRKN Mediated Mitophagy, Calnexin/calreticulin cycle, FCERI mediated NF-kB activation, Regulated Necrosis, Translesion synthesis by POLI, Negative regulation of FGFR3 signaling, Autodegradation of the E3 ubiquitin ligase COP1, Signaling by FGFR1, p53-Dependent G1 DNA Damage Response, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, Cyclin E associated events during G1/S transition , Negative regulation of FGFR4 signaling, VLDLR internalisation and degradation, Signaling by FGFR2, Metabolism of proteins, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor 5 (TLR5) Cascade, Josephin domain DUBs, Deubiquitination, Axon guidance, Asparagine N-linked glycosylation, Downregulation of ERBB4 signaling, Signaling by the B Cell Receptor (BCR), Cdc20:Phospho-APC/C mediated degradation of Cyclin A, HDR through Homologous Recombination (HRR), Signaling by ERBB4, Signaling by PTK6, Ub-specific processing proteases, Dual incision in TC-NER, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), APC/C:Cdc20 mediated degradation of Cyclin B, Cyclin A:Cdk2-associated events at S phase entry, MyD88 cascade initiated on plasma membrane, Nucleotide Excision Repair, Regulation of necroptotic cell death, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Gap-filling DNA repair synthesis and ligation in GG-NER, Regulation of RAS by GAPs, Global Genome Nucleotide Excision Repair (GG-NER), FLT3 Signaling, PTEN Regulation, TNF signaling, Stabilization of p53, Signaling by Interleukins, GTP hydrolysis and joining of the 60S ribosomal subunit, Downstream signaling events of B Cell Receptor (BCR), Regulation of signaling by CBL, Toll Like Receptor 3 (TLR3) Cascade, Cellular responses to stress, APC-Cdc20 mediated degradation of Nek2A, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Regulation of FZD by ubiquitination, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Generic Transcription Pathway, NOD1/2 Signaling Pathway, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, DNA Damage Recognition in GG-NER, Formation of Incision Complex in GG-NER, CLEC7A (Dectin-1) signaling, Dectin-1 mediated noncanonical NF-kB signaling, Formation of TC-NER Pre-Incision Complex, Degradation of AXIN, Degradation of DVL, rRNA processing in the nucleus and cytosol, Inactivation of CSF3 (G-CSF) signaling, Activation of IRF3, IRF7 mediated by TBK1, IKBKE, Toll Like Receptor TLR6:TLR2 Cascade, Regulation of PTEN stability and activity, UCH proteinases, TCR signaling, Termination of translesion DNA synthesis, Negative regulation of MAPK pathway, Translesion synthesis by POLK, Peroxisomal protein import, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Toll Like Receptor 7/8 (TLR7/8) Cascade, Regulation of PTEN localization, Fanconi Anemia Pathway, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, Aggrephagy, Signaling by Receptor Tyrosine Kinases, Immune System, Macroautophagy, Toll Like Receptor 9 (TLR9) Cascade, Signaling by TGFB family members, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, Regulation of RUNX2 expression and activity, IRAK2 mediated activation of TAK1 complex, IKK complex recruitment mediated by RIP1, PIP3 activates AKT signaling, Nonsense-Mediated Decay (NMD), Dual Incision in GG-NER, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Recognition of DNA damage by PCNA-containing replication complex, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Cellular response to hypoxia, Mitotic Anaphase, APC/C-mediated degradation of cell cycle proteins, p53-Independent DNA Damage Response, SCF(Skp2)-mediated degradation of p27/p21, Gap-filling DNA repair synthesis and ligation in TC-NER, Signaling by ROBO receptors, MAPK6/MAPK4 signaling, Translesion synthesis by REV1, Switching of origins to a post-replicative state, Plasma lipoprotein assembly, remodeling, and clearance, TCF dependent signaling in response to WNT, Nervous system development, IRAK1 recruits IKK complex, Innate Immune System, Downstream TCR signaling, Beta-catenin independent WNT signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, M Phase, p53-Independent G1/S DNA damage checkpoint, DDX58/IFIH1-mediated induction of interferon-alpha/beta, G1/S DNA Damage Checkpoints, Plasma lipoprotein clearance, Major pathway of rRNA processing in the nucleolus and cytosol, APC/C:Cdc20 mediated degradation of Securin, Mitotic Metaphase and Anaphase, Cell Cycle Checkpoints, L13a-mediated translational silencing of Ceruloplasmin expression, Downregulation of ERBB2:ERBB3 signaling, Signaling by NOTCH, Ovarian tumor domain proteases, Regulation of TP53 Activity through Phosphorylation, Separation of Sister Chromatids, Negative regulation of FLT3, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Hedgehog 'on' state, SRP-dependent cotranslational protein targeting to membrane, Protein localization, TRIF(TICAM1)-mediated TLR4 signaling , rRNA processing, G2/M Transition, Cell Cycle, Mitotic, Transcriptional Regulation by TP53, MAPK1/MAPK3 signaling, Interferon Signaling, RIPK1-mediated regulated necrosis, Death Receptor Signaling, Signaling by NOTCH1, Stimuli-sensing channels, Ion channel transport, Signaling by Non-Receptor Tyrosine Kinases, Regulation of BACH1 activity, Interleukin-1 family signaling, Intracellular signaling by second messengers, Regulation of innate immune responses to cytosolic DNA, Regulation of TP53 Expression and Degradation, Cellular response to chemical stress, Neddylation, NIK-->noncanonical NF-kB signaling, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, Assembly of the pre-replicative complex, DNA Repair, Nuclear events mediated by NFE2L2, DNA Damage Bypass, Toll Like Receptor 10 (TLR10) Cascade, Downregulation of ERBB2 signaling, Formation of a pool of free 40S subunits

Orthologs