PANTHER Gene Information   
Gene Symbol(s): Shmt1
Organism: Mus musculus
View Gene in Tree
Tree Reduced Tree  
Tree Reduced Tree
Gene Name: Serine hydroxymethyltransferase, cytosolic
Gene ID: MGI:98299
Protein ID: P50431
Persistent Id: PTN000188111
Alternate Ids:
GLYC_MOUSE(UniProtKB-ID) MGI:98299(MGI)
X94478(EMBL) Q8R0X9(AltAccession)
20425(GeneID) XM_006532644(refSeq)
CHEMBL4396(ChEMBL) ENSMUSP00000018744(Ensembl_PRO)
Shmt1(Symbol) GLYC(Synonym)
341941086(GI) ENSMUST00000018744(Ensembl_TRS)
AAK15040(EMBL-CDS) 2.1.2.1 {ECO:0000250|UniProtKB:P34896}(EC)
ENSMUSG00000020534(Ensembl)
Show All

PANTHER Classification
PANTHER Family: SERINE HYDROXYMETHYLTRANSFERASE (PTHR11680)
PANTHER Subfamily: SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC (PTHR11680:SF59)  
PANTHER GO-slim Molecular Function: anion binding
organic cyclic compound binding
transferase activity, transferring one-carbon groups
heterocyclic compound binding
PANTHER GO-slim Biological Process: proteinogenic amino acid biosynthetic process
folic acid-containing compound metabolic process
L-amino acid biosynthetic process
PANTHER GO-slim Cellular Component: mitochondrion
nucleus
PANTHER protein class: methyltransferase
Pathway Categories: Serine glycine biosynthesis
   Glycine hydroxymethyltransferase

GO MF Complete: serine binding, pyridoxal phosphate binding, identical protein binding, protein homodimerization activity, mRNA 5'-UTR binding, mRNA regulatory element binding translation repressor activity, glycine hydroxymethyltransferase activity, small molecule binding, amino acid binding, L-allo-threonine aldolase activity
GO BP Complete: cellular response to tetrahydrofolate, L-serine metabolic process, folic acid metabolic process, dTMP biosynthetic process, tetrahydrofolate metabolic process, purine nucleobase biosynthetic process, glycine biosynthetic process, L-serine catabolic process, one-carbon metabolic process, glycine metabolic process, protein homotetramerization, cellular response to leukemia inhibitory factor, glycine biosynthetic process from serine, tetrahydrofolate interconversion, negative regulation of translation
GO CC Complete: nucleus, cytoplasm, mitochondrion, cytosol, nucleoplasm
Reactome Pathways: Metabolism of vitamins and cofactors, Carnitine synthesis, Metabolism of folate and pterines, Metabolism, Metabolism of amino acids and derivatives, Metabolism of water-soluble vitamins and cofactors