PANTHER Gene Information   
Gene Symbol(s): Rap1a
Organism: Mus musculus
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Gene Name: Ras-related protein Rap-1A
Gene ID: MGI:97852
Protein ID: P62835
Persistent Id: PTN000631746
Alternate Ids:
AAH83128(EMBL-CDS) BC051419(EMBL)
P10113(AltAccession) NM_145541(refSeq)
MGI:97852(MGI) RAP1A_MOUSE(UniProtKB-ID)
Rap1a(Symbol) Krev-1(Synonym)
21704066(GI) ENSMUSP00000088174(Ensembl_PRO)
109905(GeneID) ENSMUST00000090678(Ensembl_TRS)
3.6.5.2 {ECO:0000250|UniProtKB:P61224}(EC) ENSMUSG00000068798(Ensembl)
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PANTHER Classification
PANTHER Family: RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY (PTHR24070)
PANTHER Subfamily: RAS-RELATED PROTEIN RAP-1A (PTHR24070:SF395)  
PANTHER GO-slim Molecular Function: carbohydrate derivative binding
anion binding
GTPase activity
nucleotide binding
PANTHER GO-slim Biological Process: negative regulation of transport
cellular response to oxygen-containing compound
regulation of exocytosis
cellular response to organic cyclic compound
cellular response to organonitrogen compound
regulation of neurotransmitter secretion
negative regulation of cellular process
small GTPase-mediated signal transduction
PANTHER GO-slim Cellular Component: plasma membrane
PANTHER protein class: small GTPase
Pathway Categories: Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
   Ras associated protein 1
Integrin signalling pathway
   Ras associated protein 1
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   Ras associated protein 1
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: GTP binding, protein binding, GTPase activity, G protein activity, guanyl-nucleotide exchange factor activity, GDP binding, small GTPase binding, protein-containing complex binding
GO BP Complete: small GTPase-mediated signal transduction, cellular response to nerve growth factor stimulus, nervous system development, positive regulation of D-glucose import, regulation of cell junction assembly, establishment of endothelial barrier, positive regulation of GTPase activity, positive regulation of Fc receptor mediated stimulatory signaling pathway, nerve growth factor signaling pathway, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane, negative regulation of collagen biosynthetic process, positive regulation of protein kinase activity, positive regulation of ERK1 and ERK2 cascade, cellular response to cAMP, positive regulation of vasculogenesis, response to antineoplastic agent, positive regulation of neuron projection development, cellular response to xenobiotic stimulus, synaptic vesicle exocytosis, Rap protein signal transduction, positive regulation of phagocytosis, protein localization to plasma membrane, negative regulation of synaptic vesicle exocytosis
GO CC Complete: myelin sheath, late endosome, phagocytic vesicle, neuron projection, plasma membrane, early endosome, presynapse, perinuclear region of cytoplasm, anchoring junction, sperm midpiece, cytoplasm, cell junction, guanyl-nucleotide exchange factor complex, glutamatergic synapse
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Immune System, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Regulation of insulin secretion, MET promotes cell motility, Rap1 signalling, MET activates RAP1 and RAC1, Integration of energy metabolism, p130Cas linkage to MAPK signaling for integrins, RAF/MAP kinase cascade, MAP2K and MAPK activation, Neutrophil degranulation, MAPK1/MAPK3 signaling, Signaling by NTRK1 (TRKA), Frs2-mediated activation, ARMS-mediated activation, GRB2:SOS provides linkage to MAPK signaling for Integrins , Innate Immune System, Signal Transduction, Prolonged ERK activation events, Integrin signaling, Signaling by NTRKs, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Platelet Aggregation (Plug Formation), Platelet activation, signaling and aggregation, Hemostasis, Signalling to ERKs, Metabolism, Adaptive Immune System, MAPK family signaling cascades

Orthologs