PANTHER Gene Information   
Gene Symbol(s): Nkx2-2
Organism: Mus musculus
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Gene Name: Homeobox protein Nkx-2.2
Gene ID: MGI:97347
Protein ID: P42586
Persistent Id: PTN000678557
Alternate Ids:
6754860(GI) ENSMUSG00000027434(Ensembl)
NKX22(Synonym) Nkx2-2(Symbol)
18088(GeneID) ENSMUSP00000069666(Ensembl_PRO)
NKX22_MOUSE(UniProtKB-ID) MGI:97347(MGI)
ENSMUST00000067075(Ensembl_TRS) XP_011237651(refSeq)
U31566(EMBL) AAA79303(EMBL-CDS)
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PANTHER Classification
PANTHER Family: HOMEOBOX PROTEIN NKX (PTHR24340)
PANTHER Subfamily: HOMEOBOX PROTEIN NKX-2.2 (PTHR24340:SF24)  
PANTHER GO-slim Molecular Function: DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II cis-regulatory region sequence-specific DNA binding
PANTHER GO-slim Biological Process: regulation of transcription by RNA polymerase II
cell differentiation
PANTHER GO-slim Cellular Component: nucleus
PANTHER protein class: homeodomain transcription factor
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: DNA-binding transcription factor activity, protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, transcription factor binding, DNA-binding transcription factor activity, RNA polymerase II-specific
GO BP Complete: oligodendrocyte development, ventral spinal cord interneuron fate determination, response to progesterone, nervous system development, negative regulation of neuron differentiation, positive regulation of neuron differentiation, central nervous system neuron differentiation, positive regulation of transcription by RNA polymerase II, spinal cord oligodendrocyte cell fate specification, optic nerve development, positive regulation of oligodendrocyte differentiation, pancreatic A cell fate commitment, response to glucose, type B pancreatic cell fate commitment, neuron fate specification, pancreatic PP cell fate commitment, digestive tract development, type B pancreatic cell differentiation, endocrine pancreas development, oligodendrocyte differentiation, neuroendocrine cell differentiation, astrocyte differentiation, neuron differentiation, spinal cord oligodendrocyte cell differentiation, spinal cord motor neuron differentiation, regulation of DNA-templated transcription, smoothened signaling pathway, cell development, type B pancreatic cell development, regulation of transcription by RNA polymerase II, positive regulation of epithelial cell differentiation, positive regulation of gene expression, cell differentiation
GO CC Complete: nucleus, intracellular anatomical structure
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: -

Orthologs