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Gene Symbol(s):
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Ptpn6
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| Organism: |
Mus musculus |
| View Gene in Tree |
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| Gene Name: |
Tyrosine-protein phosphatase non-receptor type 6
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| Gene ID: |
MGI:96055
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| Protein ID: |
P29351
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| Persistent Id: |
PTN000439391 |
| Alternate Ids: |
| 15215088(GI) |
Q63874(AltAccession) |
| AAA40007(EMBL-CDS) |
ENSMUSG00000004266(Ensembl) |
| PTN6_MOUSE(UniProtKB-ID) |
MGI:96055(MGI) |
| PTN6(Synonym) |
U65953(EMBL) |
15170(GeneID) |
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Show All
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| GO MF Complete: |
protein kinase binding, phosphorylation-dependent protein binding, cell adhesion molecule binding, transmembrane receptor protein tyrosine phosphatase activity, SH2 domain binding, natural killer cell lectin-like receptor binding, cytokine receptor binding, phosphotyrosine residue binding, protein binding, non-membrane spanning protein tyrosine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine phosphatase activity, metal-dependent, SH3 domain binding, histone H2AXY142 phosphatase activity
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| GO BP Complete: |
negative regulation of angiogenesis, peptidyl-tyrosine phosphorylation, negative regulation of MAP kinase activity, negative regulation of MAPK cascade, positive regulation of cell population proliferation, epididymis development, negative regulation of innate immune response, mitotic cell cycle, hematopoietic progenitor cell differentiation, MAPK cascade, chromatin remodeling, cytokine-mediated signaling pathway, platelet formation, megakaryocyte development, CD27 signaling pathway, negative regulation of B cell receptor signaling pathway, positive regulation of cell adhesion mediated by integrin, negative regulation of inflammatory response to wounding, peptidyl-tyrosine dephosphorylation, platelet aggregation, negative regulation of tumor necrosis factor production, intracellular signal transduction, T cell receptor signaling pathway, negative regulation of peptidyl-tyrosine phosphorylation, B cell receptor signaling pathway, negative regulation of neutrophil activation, protein dephosphorylation, regulation of B cell differentiation, natural killer cell mediated cytotoxicity, negative regulation of interleukin-6 production, regulation of release of sequestered calcium ion into cytosol, regulation of ERK1 and ERK2 cascade, negative regulation of T cell receptor signaling pathway, negative regulation of T cell proliferation, negative regulation of humoral immune response mediated by circulating immunoglobulin, T cell proliferation, cell differentiation, regulation of G1/S transition of mitotic cell cycle, negative regulation of mast cell activation involved in immune response, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of lipopolysaccharide-mediated signaling pathway
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| GO CC Complete: |
nucleus, apical dendrite, cell-cell junction, cytoplasm, cytosol, protein-containing complex, nucleolus, plasma membrane, alpha-beta T cell receptor complex, nucleoplasm
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| Reactome Pathways: |
Immune System, Signaling by Receptor Tyrosine Kinases, Interleukin receptor SHC signaling, PD-1 signaling, Cell surface interactions at the vascular wall, Platelet sensitization by LDL, PECAM1 interactions, Interferon alpha/beta signaling, Signaling by the B Cell Receptor (BCR), Neutrophil degranulation, Interferon Signaling, Interleukin-2 family signaling, Innate Immune System, Signal Transduction, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, CD22 mediated BCR regulation, Signaling by ALK, Platelet homeostasis, Interleukin-3, Interleukin-5 and GM-CSF signaling, Costimulation by the CD28 family, GPVI-mediated activation cascade, Signaling by SCF-KIT, Platelet activation, signaling and aggregation, Regulation of KIT signaling, Hemostasis, Signaling by Interleukins, Cytokine Signaling in Immune system, Regulation of IFNA/IFNB signaling, Adaptive Immune System, Interferon gamma signaling
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