PANTHER Gene Information

Gene Symbol(s):

Organism:

Mus musculus

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Gene Name:

Complement C5

Gene ID:

MGI:96031

Protein ID:

P06684

Persistent Id:

PTN000151375

Alternate Ids:

CO5_MOUSE(UniProtKB-ID)	MGI:96031(MGI)
NP_034536(refSeq)	A2AS36(AltAccession)
116608(GI)	M35525(EMBL)
CO5(Synonym)	AAA37349(EMBL-CDS)
15139(GeneID)	ENSMUSP00000028233(Ensembl_PRO)
C5(Symbol)	ENSMUSG00000026874(Ensembl)
ENSMUST00000028233(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	MACROGLOBULIN / COMPLEMENT (PTHR11412)
PANTHER Subfamily:	COMPLEMENT C5 (PTHR11412:SF83)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	protease inhibitor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	endopeptidase inhibitor activity
GO BP Complete:	inflammatory response to wounding, neutrophil homeostasis, positive regulation of angiogenesis, complement activation, alternative pathway, inflammatory response, glomerulus development, in utero embryonic development, kidney development, complement activation, classical pathway, killing of cells of another organism, positive regulation of chemokine production, negative regulation of macrophage chemotaxis, positive regulation of vascular endothelial growth factor production
GO CC Complete:	membrane attack complex, extracellular space

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Immune System, GPCR ligand binding, G alpha (i) signalling events, Innate Immune System, Signal Transduction, Terminal pathway of complement, Complement cascade, GPCR downstream signalling, Peptide ligand-binding receptors, Activation of C3 and C5, Class A/1 (Rhodopsin-like receptors), Signaling by GPCR, Regulation of Complement cascade

Orthologs

ID	Organism	Type
HUMAN\|HGNC=1331\|UniProtKB=P01031	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000021309.3\|UniProtKB=H2QXT1	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000002285.3\|UniProtKB=G3QIN8	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000020124.4\|UniProtKB=F7GHV1	Macaca mulatta	LDO
RAT\|RGD=2237\|UniProtKB=P08650	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000012210.6\|UniProtKB=F1MY85	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000005512.5\|UniProtKB=A0A287AIM8	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000020296.4\|UniProtKB=A0A9L0RMF3	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000000645.6\|UniProtKB=M3VV58	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845014898.1\|UniProtKB=A0A8I3NVC1	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000019641.3\|UniProtKB=F6URG6	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000001103.3\|UniProtKB=F6XII7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010029141.1\|UniProtKB=A0A8V1AM71	Gallus gallus	LDO
XENLA\|Gene=c5.L\|UniProtKB=A0A8J1LGY3	Xenopus laevis	O
XENLA\|Gene=c5.2.L\|UniProtKB=A0A8J1LFJ4	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-486371\|UniProtKB=A0A8J0QGT7	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000017552.2\|UniProtKB=H2MT65	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-120510-2\|UniProtKB=E7FCV2	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000005479.1\|UniProtKB=W5ME05	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000019625.1\|UniProtKB=H2Y2X2	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000001054.3\|UniProtKB=F6U649	Ciona intestinalis	O
BRAFL\|Gene=LOC118403166\|UniProtKB=A0A9J7HHW2	Branchiostoma floridae	O
STRPU\|EnsemblGenome=GeneID_373284\|UniProtKB=O44344	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100892832\|UniProtKB=A0A7M7PMG7	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC575436\|UniProtKB=A0A7M7TG33	Strongylocentrotus purpuratus	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g210666\|UniProtKB=A7SDN3	Nematostella vectensis	O