PANTHER Gene Information   
Gene Symbol(s): Gsn
Organism: Mus musculus
View Gene in Tree
Tree Reduced Tree  
Tree Reduced Tree
Gene Name: Gelsolin
Gene ID: MGI:95851
Protein ID: P13020
Persistent Id: PTN000240182
Alternate Ids:
Q3UPB1(AltAccession) 31615699(GI)
MGI:95851(MGI) GELS_MOUSE(UniProtKB-ID)
AAH23143(EMBL-CDS) J04953(EMBL)
227753(GeneID) ENSMUSG00000026879(Ensembl)
Gsn(Symbol) GELS(Synonym)
Show All

PANTHER Classification
PANTHER Family: VILLIN (PTHR11977)
PANTHER Subfamily: GELSOLIN (PTHR11977:SF29)  
PANTHER GO-slim Molecular Function: actin filament binding
phosphatidylinositol-4,5-bisphosphate binding
PANTHER GO-slim Biological Process: central nervous system development
actin polymerization or depolymerization
cell projection assembly
barbed-end actin filament capping
PANTHER GO-slim Cellular Component: extracellular space
cytoplasm
actin cytoskeleton
PANTHER protein class: non-motor actin binding protein
Pathway Categories: FAS signaling pathway
   Gelsolin

GO MF Complete: actin filament binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding, actin binding, calcium ion binding, myosin II binding, phosphatidylinositol 3-kinase catalytic subunit binding
GO BP Complete: positive regulation of keratinocyte apoptotic process, cell projection assembly, actin filament organization, regulation of establishment of T cell polarity, positive regulation of protein processing in phagocytic vesicle, phagocytosis, engulfment, vesicle-mediated transport, cellular response to cadmium ion, positive regulation of cardiac muscle hypertrophy, response to muscle stretch, positive regulation of actin nucleation, cardiac muscle cell contraction, striated muscle atrophy, cilium assembly, actin polymerization or depolymerization, actin filament depolymerization, actin filament polymerization, hepatocyte apoptotic process, positive regulation of p38MAPK cascade, amyloid fibril formation, protein destabilization, regulation of plasma membrane raft polarization, barbed-end actin filament capping, central nervous system development, actin filament severing, actin filament capping, host-mediated suppression of symbiont invasion, positive regulation of gene expression, renal protein absorption, regulation of receptor clustering, cellular response to type II interferon, actin cytoskeleton organization, relaxation of cardiac muscle, regulation of podosome assembly
GO CC Complete: myelin sheath, sarcoplasm, phagocytic vesicle, extracellular region, apical ectoplasmic specialization, plasma membrane, basal ectoplasmic specialization, podosome, nucleus, extracellular space, perinuclear region of cytoplasm, focal adhesion, cytoplasm, ruffle, actin cytoskeleton, cytosol, glial filament, protein-containing complex, cortical actin cytoskeleton, lamellipodium, actin cap
Reactome Pathways: Immune System, Programmed Cell Death, Caspase-mediated cleavage of cytoskeletal proteins, Innate Immune System, Neutrophil degranulation, Apoptosis, Apoptotic execution phase, Apoptotic cleavage of cellular proteins