PANTHER Gene Information   
Gene Symbol(s): Gata2
Organism: Mus musculus
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Gene Name: Endothelial transcription factor GATA-2
Gene ID: MGI:95662
Protein ID: O09100
Persistent Id: PTN000007704
Alternate Ids:
ENSMUSG00000015053(Ensembl) 226530726(GI)
ENSMUST00000015197(Ensembl_TRS) MGI:95662(MGI)
GATA2(Synonym) AB000096(EMBL)
Gata2(Symbol) ENSMUSP00000128198(Ensembl_PRO)
XM_006505539(refSeq) GATA2_MOUSE(UniProtKB-ID)
BAA19053(EMBL-CDS) 14461(GeneID)
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PANTHER Classification
PANTHER Family: TRANSCRIPTION FACTOR GATA FAMILY MEMBER (PTHR10071)
PANTHER Subfamily: ENDOTHELIAL TRANSCRIPTION FACTOR GATA-2 (PTHR10071:SF149)  
PANTHER GO-slim Molecular Function: DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II cis-regulatory region sequence-specific DNA binding
PANTHER GO-slim Biological Process: cell fate commitment
regulation of angiogenesis
negative regulation of transcription by RNA polymerase II
positive regulation of multicellular organismal process
positive regulation of developmental process
positive regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component: nucleus
PANTHER protein class: DNA-binding transcription factor
Pathway Categories: Gonadotropin-releasing hormone receptor pathway
   GATA2/4
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: zinc ion binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, chromatin binding, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription coactivator binding, transcription coregulator binding, DNA binding, DNA-binding transcription factor activity, protein binding, RNA polymerase II-specific DNA-binding transcription factor binding, C2H2 zinc finger domain binding, sequence-specific double-stranded DNA binding
GO BP Complete: positive regulation of mast cell degranulation, negative regulation of brown fat cell differentiation, thyroid-stimulating hormone-secreting cell differentiation, transcription by RNA polymerase II, central nervous system neuron differentiation, ventral spinal cord interneuron differentiation, central nervous system neuron development, fat cell differentiation, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of erythrocyte differentiation, hematopoietic progenitor cell differentiation, positive regulation of angiogenesis, brown fat cell differentiation, neuroblast proliferation, negative regulation of neuroblast proliferation, negative regulation of macrophage differentiation, negative regulation of endothelial cell apoptotic process, cell fate determination, semicircular canal development, cochlea development, neuron differentiation, vascular wound healing, commitment of neuronal cell to specific neuron type in forebrain, hematopoietic stem cell homeostasis, positive regulation of megakaryocyte differentiation, pituitary gland development, negative regulation of gene expression, positive regulation of gene expression, inner ear morphogenesis, myeloid cell differentiation, positive regulation of phagocytosis, positive regulation of phagocytosis, engulfment, neural precursor cell proliferation, cell differentiation in hindbrain, neuron maturation, positive regulation of neuron differentiation, positive regulation of miRNA transcription, positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, negative regulation of Notch signaling pathway, positive regulation of transcription by RNA polymerase II, glandular epithelial cell differentiation, embryonic placenta development, negative regulation of transcription by RNA polymerase II, neuron migration, angiogenesis, regulation of forebrain neuron differentiation, neuron fate commitment, somatic stem cell population maintenance, negative regulation of neural precursor cell proliferation, response to lipid, eosinophil fate commitment, neuroendocrine cell differentiation, negative regulation of myeloid cell differentiation, glandular epithelial cell maturation, negative regulation of hematopoietic progenitor cell differentiation, positive regulation of blood vessel endothelial cell migration, positive regulation of cytosolic calcium ion concentration, definitive hemopoiesis, GABAergic neuron differentiation, urogenital system development, regulation of primitive erythrocyte differentiation, homeostasis of number of cells within a tissue, cell fate commitment, phagocytosis
GO CC Complete: nucleus, transcription regulator complex, cytoplasm, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: RUNX1 regulates transcription of genes involved in differentiation of HSCs, Hemostasis, Generic Transcription Pathway, Transcriptional regulation by RUNX1, Factors involved in megakaryocyte development and platelet production, Gene expression (Transcription), RNA Polymerase II Transcription

Orthologs