PANTHER Gene Information   
Gene Symbol(s): Cdk4
Organism: Mus musculus
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Gene Name: Cyclin-dependent kinase 4
Gene ID: MGI:88357
Protein ID: P30285
Persistent Id: PTN000623260
Alternate Ids:
53194(GI) AAH52694(EMBL-CDS)
NM_009870(refSeq) 2.7.11.22(EC)
MGI:88357(MGI) CDK4_MOUSE(UniProtKB-ID)
PSK-J3(Synonym) BC052694(EMBL)
12567(GeneID) CHEMBL2134(ChEMBL)
Cdk4(Symbol) ENSMUSG00000006728(Ensembl)
ENSMUSP00000006911(Ensembl_PRO) ENSMUST00000006911(Ensembl_TRS)
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PANTHER Classification
PANTHER Family: CELL DIVISION PROTEIN KINASE (PTHR24056)
PANTHER Subfamily: CYCLIN-DEPENDENT KINASE 4 (PTHR24056:SF129)  
PANTHER GO-slim Molecular Function: cyclin-dependent protein serine/threonine kinase activity
cyclin binding
PANTHER GO-slim Biological Process: G1/S transition of mitotic cell cycle
response to organic substance
protein phosphorylation
signal transduction
regulation of gene expression
regulation of G2/M transition of mitotic cell cycle
PANTHER GO-slim Cellular Component: cytoplasm
cyclin-dependent protein kinase holoenzyme complex
nucleus
PANTHER protein class: non-receptor serine/threonine protein kinase
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ATP binding, protein binding, protein kinase activity, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, protein serine kinase activity, protein-containing complex binding
GO BP Complete: positive regulation of translation, signal transduction, positive regulation of cell population proliferation, response to xenobiotic stimulus, protein phosphorylation, cellular response to phorbol 13-acetate 12-myristate, regulation of type B pancreatic cell proliferation, cellular response to ionomycin, cell division, positive regulation of cell size, cellular response to lipopolysaccharide, positive regulation of fibroblast proliferation, G1/S transition of mitotic cell cycle, positive regulation of apoptotic process, cellular response to interleukin-4, regulation of gene expression, response to testosterone, regulation of cell cycle, response to lead ion, positive regulation of epithelial cell proliferation, regulation of G2/M transition of mitotic cell cycle, positive regulation of G2/M transition of mitotic cell cycle
GO CC Complete: cyclin-dependent protein kinase holoenzyme complex, nucleolus, chromatin, nucleoplasm, cyclin D3-CDK4 complex, nucleus, transcription regulator complex, bicellular tight junction, nuclear membrane, perinuclear region of cytoplasm, cytoplasm, cyclin D1-CDK4 complex, cytosol, cyclin D2-CDK4 complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Cellular responses to stimuli, Generic Transcription Pathway, Transcriptional regulation of granulopoiesis, G1/S Transition, Chromatin modifying enzymes, Gene expression (Transcription), PTK6 Regulates Cell Cycle, Cyclin D associated events in G1, Cell Cycle, Mitotic, G1 Phase, Oncogene Induced Senescence, SCF(Skp2)-mediated degradation of p27/p21, Cellular Senescence, Senescence-Associated Secretory Phenotype (SASP), Signaling by PTK6, Oxidative Stress Induced Senescence, RMTs methylate histone arginines, Developmental Biology, Chromatin organization, Signaling by Non-Receptor Tyrosine Kinases, Signal Transduction, Cyclin A:Cdk2-associated events at S phase entry, Drug-mediated inhibition of CDK4/CDK6 activity, Transcriptional regulation by RUNX2, S Phase, Mitotic G1 phase and G1/S transition, Cyclin E associated events during G1/S transition , Cell Cycle, Ubiquitin-dependent degradation of Cyclin D, Cellular responses to stress, RNA Polymerase II Transcription

Orthologs