PANTHER Gene Information

Gene Symbol(s):

Ccnd2

Organism:

Mus musculus

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Gene Name:

G1_S-specific cyclin-D2

Gene ID:

MGI:88314

Protein ID:

P30280

Persistent Id:

PTN000020308

Alternate Ids:

CCND2_MOUSE(UniProtKB-ID)	XP_006505522(refSeq)
CCND2(Synonym)	MGI:88314(MGI)
M86182(EMBL)	ENSMUST00000000188(Ensembl_TRS)
ENSMUSG00000000184(Ensembl)	AAA37519(EMBL-CDS)
Ccnd2{ECO:0000312\|MGI:MGI:88314}(Symbol)	568940501(GI)
12444(GeneID)	ENSMUSP00000000188(Ensembl_PRO)
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PANTHER Classification

PANTHER Family:	CYCLINS (PTHR10177)
PANTHER Subfamily:	G1_S-SPECIFIC CYCLIN-D2 (PTHR10177:SF66)
PANTHER GO-slim Molecular Function:	protein kinase regulator activity
PANTHER GO-slim Biological Process:	positive regulation of cell cycle G1/S phase transition G1/S transition of mitotic cell cycle regulation of cyclin-dependent protein serine/threonine kinase activity regulation of G1/S transition of mitotic cell cycle positive regulation of mitotic cell cycle
PANTHER GO-slim Cellular Component:	cytoplasm centrosome cyclin-dependent protein kinase holoenzyme complex nucleus
PANTHER protein class:	kinase activator

Pathway Categories:

Cell cycle

Cyclin D

PI3 kinase pathway

Cyclin d

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	protein kinase binding, cyclin-dependent protein serine/threonine kinase activator activity, protein binding, cyclin-dependent protein serine/threonine kinase regulator activity
GO BP Complete:	positive regulation of cardiac muscle cell proliferation, positive regulation of cyclin-dependent protein serine/threonine kinase activity, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of cell population proliferation, adult locomotory behavior, long-term memory, cell division, cellular response to X-ray, negative regulation of apoptotic process, G1/S transition of mitotic cell cycle, positive regulation of protein phosphorylation, negative regulation of cardiac muscle cell differentiation, regulation of cell cycle, positive regulation of epithelial cell proliferation
GO CC Complete:	nucleus, nuclear membrane, microtubule organizing center, cytoplasm, cyclin-dependent protein kinase holoenzyme complex, cytosol, cyclin D2-CDK4 complex, nucleolus, chromatin, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Regulation of RUNX1 Expression and Activity, Cyclin D associated events in G1, Mitotic G1 phase and G1/S transition, Cell Cycle, Mitotic, G1 Phase, Generic Transcription Pathway, Drug-mediated inhibition of CDK4/CDK6 activity, Transcriptional regulation by RUNX1, Cell Cycle, Gene expression (Transcription), RNA Polymerase II Transcription

Orthologs

ID	Organism	Type
HUMAN\|HGNC=1583\|UniProtKB=P30279	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000004549.3\|UniProtKB=H2Q584	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000009479.3\|UniProtKB=G3R223	Gorilla gorilla gorilla	LDO
RAT\|RGD=621083\|UniProtKB=Q04827	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000016649\|UniProtKB=Q0P5D3	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000038694\|UniProtKB=Q8WNW2	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000012663.4\|UniProtKB=A0A9L0TIJ5	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000046690.2\|UniProtKB=M3VU57	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845030681.1\|UniProtKB=A0A8I3Q7A5	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000018312.4\|UniProtKB=F6PTI2	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000014696.3\|UniProtKB=A0A6I8N7A6	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010024285\|UniProtKB=P49706	Gallus gallus	LDO
XENLA\|Gene=ccnd2\|UniProtKB=P53782	Xenopus laevis	O
XENLA\|Gene=ccnd2.S\|UniProtKB=Q3KPK0	Xenopus laevis	LDO
ORYLA\|Ensembl=ENSORLG00000000235.2\|UniProtKB=H2L3G9	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-041010-110\|UniProtKB=Q5XJ98	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000012668.1\|UniProtKB=W5N4M9	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000001767.2\|UniProtKB=H2L8M5	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-080917-47\|UniProtKB=D3GDI9	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000015840.2\|UniProtKB=A0A3B3I1Z4	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000025430.1\|UniProtKB=A0A3B3I2H1	Oryzias latipes	LDO
DANRE\|Gene=ccnd2b\|UniProtKB=A0A8M2BBN7	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-070424-30\|UniProtKB=A3KNN7	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000016674.1\|UniProtKB=W5NIY9	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000015047.2\|UniProtKB=F6S8K9	Ciona intestinalis	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_271951\|UniProtKB=C3ZNJ6	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC115927903\|UniProtKB=Q964G0	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00000870\|UniProtKB=Q9U2M5	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00025758\|UniProtKB=Q8MUK1	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00277522\|UniProtKB=A0A2A6CT06	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0010315\|UniProtKB=Q7KUZ5	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP029544\|UniProtKB=A0A453Z020	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC008270\|UniProtKB=D2A0U5	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC032882\|UniProtKB=A0A139WJW6	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_46610\|UniProtKB=E9G6I6	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG68430\|UniProtKB=T1FZE6	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g237657\|UniProtKB=A7T1H9	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG37409\|UniProtKB=B3RT03	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_6465\|UniProtKB=A9UTY7	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_14677\|UniProtKB=A9US68	Monosiga brevicollis	O
SCHPO\|PomBase=SPBC2G2.09c\|UniProtKB=O43008	Schizosaccharomyces pombe	O
SCHPO\|PomBase=SPBC16E9.17c\|UniProtKB=O14332	Schizosaccharomyces pombe	O
ENTH1\|EnsemblGenome=CL6EHI_142110\|UniProtKB=C4LW56	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0277439\|UniProtKB=Q8T2F2	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0279085\|UniProtKB=Q1ZXI1	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_51276\|UniProtKB=F1A2Z4	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_25_0810\|UniProtKB=Q4QA13	Leishmania major	O
CHLRE\|EnsemblGenome=CHLRE_17g698150v5\|UniProtKB=A0A2K3CNQ7	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_04g221301v5\|UniProtKB=A0A2K3DU98	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_17g711550v5\|UniProtKB=A0A2K3CPN6	Chlamydomonas reinhardtii	O