PANTHER Gene Information   
Gene Symbol(s): Calr
Organism: Mus musculus
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Gene Name: Calreticulin
Gene ID: MGI:88252
Protein ID: P14211
Persistent Id: PTN000117449
Alternate Ids:
MGI:88252(MGI) M92988(EMBL)
Q3TVD2(AltAccession) CALR_MOUSE(UniProtKB-ID)
117502(GI) NM_007591(refSeq)
AAH03453(EMBL-CDS) ENSMUSG00000003814(Ensembl)
Calr(Symbol) ENSMUST00000003912(Ensembl_TRS)
ENSMUSP00000003912(Ensembl_PRO) Endoplasmic reticulum resident protein 60(Synonym)
12317(GeneID)
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PANTHER Classification
PANTHER Family: CALRETICULIN AND CALNEXIN (PTHR11073)
PANTHER Subfamily: CALRETICULIN (PTHR11073:SF16)  
PANTHER GO-slim Molecular Function: calcium ion binding
PANTHER GO-slim Biological Process: protein folding
ERAD pathway
PANTHER GO-slim Cellular Component: endoplasmic reticulum membrane
PANTHER protein class: chaperone
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: hormone binding, integrin binding, peptide binding, unfolded protein binding, nuclear export signal receptor activity, protein binding, ubiquitin protein ligase binding, protein folding chaperone, nuclear androgen receptor binding, iron ion binding, calcium ion binding, mRNA binding, complement component C1q complex binding, molecular sequestering activity, carbohydrate binding
GO BP Complete: negative regulation of intracellular steroid hormone receptor signaling pathway, negative regulation of trophoblast cell migration, positive regulation of cell population proliferation, cellular senescence, negative regulation of neuron differentiation, positive regulation of non-canonical NF-kappaB signal transduction, response to biphenyl, positive regulation of cell cycle, response to xenobiotic stimulus, negative regulation of transcription by RNA polymerase II, cortical actin cytoskeleton organization, negative regulation of DNA-templated transcription, negative regulation of retinoic acid receptor signaling pathway, positive regulation of dendritic cell chemotaxis, cellular response to electrical stimulus, response to testosterone, positive regulation of endothelial cell migration, negative regulation of translation, protein localization to nucleus, cardiac muscle cell differentiation, ERAD pathway, spermatogenesis, regulation of meiotic nuclear division, response to peptide, positive regulation of substrate adhesion-dependent cell spreading, protein folding, protein export from nucleus, response to glycoside, cellular response to virus, cellular response to lithium ion, peptide antigen assembly with MHC class I protein complex, positive regulation of gene expression, response to estradiol, positive regulation of phagocytosis, protein stabilization
GO CC Complete: sarcoplasmic reticulum, smooth endoplasmic reticulum, collagen-containing extracellular matrix, external side of plasma membrane, extracellular region, endoplasmic reticulum membrane, endoplasmic reticulum lumen, postsynapse, acrosomal vesicle, cytosol, glutamatergic synapse, sarcoplasmic reticulum lumen, cortical granule, MHC class I peptide loading complex, endoplasmic reticulum quality control compartment, phagocytic vesicle, endoplasmic reticulum, ribosome, cell surface, nuclear envelope, nucleus, extracellular space, cytolytic granule, perinuclear region of cytoplasm, cytoplasm, mitochondrion, membrane, protein-containing complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Immune System, Calnexin/calreticulin cycle, Asparagine N-linked glycosylation, Class I MHC mediated antigen processing & presentation, Antigen processing-Cross presentation, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, ER-Phagosome pathway, Vesicle-mediated transport, Binding and Uptake of Ligands by Scavenger Receptors, Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Metabolism of proteins, Scavenging by Class A Receptors, Post-translational protein modification

Orthologs