PANTHER Gene Information   
Gene Symbol(s): Ada
Organism: Mus musculus
View Gene in Tree
Tree Reduced Tree  
Tree Reduced Tree
Gene Name: Adenosine deaminase
Gene ID: MGI:87916
Protein ID: P03958
Persistent Id: PTN000150957
Alternate Ids:
3892024(GI) M34243(EMBL)
ENSMUSP00000017841(Ensembl_PRO) 11486(GeneID)
Adenosine aminohydrolase(Synonym) CHEMBL3206(ChEMBL)
ENSMUST00000017841(Ensembl_TRS) Ada(Symbol)
ENSMUSG00000017697(Ensembl) AAB07142(EMBL-CDS)
ADA_MOUSE(UniProtKB-ID) MGI:87916(MGI)
3.5.4.4 {ECO:0000269|PubMed:10720488, ECO:0000269|PubMed:8634299, ECO:0000269|PubMed:8672487, ECO:0000269|PubMed:8942668, ECO:0000269|PubMed:9272950}(EC) NM_007398(refSeq)
Show All

PANTHER Classification
PANTHER Family: ADENOSINE DEAMINASE (PTHR11409)
PANTHER Subfamily: ADENOSINE DEAMINASE (PTHR11409:SF43)  
PANTHER GO-slim Molecular Function: adenosine deaminase activity
PANTHER GO-slim Biological Process: purine nucleoside catabolic process
purine nucleobase metabolic process
small molecule biosynthetic process
nucleobase-containing compound biosynthetic process
carbohydrate derivative biosynthetic process
adenosine metabolic process
purine-containing compound biosynthetic process
PANTHER GO-slim Cellular Component: cytosol
PANTHER protein class: deaminase
Pathway Categories: Adenine and hypoxanthine salvage pathway
   Deoxyadenosine deaminase
Adenine and hypoxanthine salvage pathway
   Adenosine deaminase

GO MF Complete: purine nucleoside binding, zinc ion binding, 2'-deoxyadenosine deaminase activity, adenosine deaminase activity, deaminase activity
GO BP Complete: positive regulation of heart rate, hypoxanthine salvage, dAMP catabolic process, negative regulation of penile erection, negative regulation of adenosine receptor signaling pathway, allantoin metabolic process, lung alveolus development, germinal center B cell differentiation, positive regulation of T cell activation, response to hypoxia, histamine secretion, hypoxanthine biosynthetic process, embryonic digestive tract development, in utero embryonic development, positive regulation of germinal center formation, negative regulation of thymocyte apoptotic process, apoptotic process, thymocyte apoptotic process, trophectodermal cell differentiation, calcium-mediated signaling, dATP catabolic process, AMP salvage, negative regulation of inflammatory response, response to purine-containing compound, B cell proliferation, inosine biosynthetic process, negative regulation of leukocyte migration, T cell differentiation, regulation of T cell differentiation, penile erection, positive regulation of T cell differentiation, xanthine biosynthetic process, positive regulation of B cell proliferation, amide catabolic process, positive regulation of T cell differentiation in thymus, T cell activation, cell adhesion, alpha-beta T cell differentiation, placenta development, regulation of T cell differentiation in thymus, positive regulation of alpha-beta T cell differentiation, positive regulation of smooth muscle contraction, positive regulation of calcium-mediated signaling, adenosine metabolic process, smooth muscle contraction, liver development, Peyer's patch development, regulation of cell-cell adhesion mediated by integrin, T cell receptor signaling pathway, lung development, AMP catabolic process, GMP salvage, IMP salvage, T cell differentiation in thymus, purine nucleotide salvage, response to vitamin E, deoxyadenosine catabolic process, adenosine catabolic process, negative regulation of circadian sleep/wake cycle, non-REM sleep, inhibition of non-skeletal tissue mineralization, germinal center formation, positive regulation of T cell receptor signaling pathway, mucus secretion, mature B cell apoptotic process, negative regulation of apoptotic process, leukocyte migration, negative regulation of mucus secretion, negative regulation of mature B cell apoptotic process
GO CC Complete: extracellular space, anchoring junction, cytoplasm, membrane, dendrite cytoplasm, external side of plasma membrane, cytosol, neuronal cell body, plasma membrane, lysosome, cell surface, cytoplasmic vesicle lumen
Reactome Pathways: Metabolism of nucleotides, Metabolism, Nucleotide salvage, Drug ADME, Ribavirin ADME, Purine salvage