PANTHER Gene Information

Gene Symbol(s):

Arhgef15

Organism:

Mus musculus

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Gene Name:

Rho guanine nucleotide exchange factor 15

Gene ID:

MGI:3045246

Protein ID:

Q5FWH6

Persistent Id:

PTN000303895

Alternate Ids:

442801(GeneID)	BC116344(EMBL)
Arhgef15(Symbol)	Kiaa0915(Synonym)
ENSMUSG00000052921(Ensembl)	AAI16344(EMBL-CDS)
XP_006533729(refSeq)	60279700(GI)
ARHGF_MOUSE(UniProtKB-ID)	Q69ZV7(AltAccession)
MGI:3045246(MGI)
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PANTHER Classification

PANTHER Family:	GUANINE NUCLEOTIDE EXCHANGE FACTOR (PTHR12845)
PANTHER Subfamily:	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 15 (PTHR12845:SF7)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:	activation of GTPase activity
PANTHER GO-slim Cellular Component:
PANTHER protein class:	guanyl-nucleotide exchange factor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	protein binding, guanyl-nucleotide exchange factor activity, GTPase activator activity
GO BP Complete:	retina vasculature morphogenesis in camera-type eye, regulation of actin cytoskeleton organization, positive regulation of stress fiber assembly, regulation of postsynapse assembly, regulation of catalytic activity, negative regulation of synapse maturation
GO CC Complete:	dendrite, postsynapse, cytoplasm, glutamatergic synapse

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Signaling by Rho GTPases, G alpha (12/13) signalling events, Signal Transduction, Cell death signalling via NRAGE, NRIF and NADE, GPCR downstream signalling, RHOA GTPase cycle, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, p75 NTR receptor-mediated signalling, RHO GTPase cycle, NRAGE signals death through JNK, Signaling by GPCR, RAC1 GTPase cycle, Death Receptor Signaling, CDC42 GTPase cycle

Orthologs

ID	Organism	Type
HUMAN\|HGNC=15590\|UniProtKB=O94989	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000023922.4\|UniProtKB=H2R3P8	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000011989.3\|UniProtKB=G3R8J7	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000008749.4\|UniProtKB=F7DVJ6	Macaca mulatta	LDO
RAT\|RGD=1306961\|UniProtKB=A0A0G2JTU0	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000020688.6\|UniProtKB=E1BDY4	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000028048.3\|UniProtKB=I3LPE0	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000015545.4\|UniProtKB=A0A3Q2HWT6	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000001665.6\|UniProtKB=M3VX24	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845000473.1\|UniProtKB=A0A8I3MKS4	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000007975.4\|UniProtKB=F7DQM9	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000042400.1\|UniProtKB=A0A6I8NAC3	Ornithorhynchus anatinus	LDO
ANOCA\|Ensembl=ENSACAG00000003870.4\|UniProtKB=H9G8A7	Anolis carolinensis	LDO
XENLA\|Gene=arhgef15.S\|UniProtKB=A0A8J1MU83	Xenopus laevis	O
XENLA\|Gene=arhgef15.L\|UniProtKB=A0A1L8H465	Xenopus laevis	LDO
XENTR\|Ensembl=ENSXETG00000047409\|UniProtKB=A0A803J2W2	Xenopus tropicalis	LDO
DANRE\|Gene=LOC101882153\|UniProtKB=A0A8M9Q6T4	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000006320.1\|UniProtKB=W5MGX0	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000006596.2\|UniProtKB=H2LQD6	Oryzias latipes	LDO
DANRE\|Gene=arhgef15\|UniProtKB=A0A8M6Z762	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-060810-103\|UniProtKB=A0A8M3BE83	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000013928.1\|UniProtKB=W5N966	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118413150\|UniProtKB=A0A9J7MLJ8	Branchiostoma floridae	O
BRAFL\|Gene=LOC118413143\|UniProtKB=A0A9J7KXP7	Branchiostoma floridae	O
BRAFL\|Gene=LOC118416293\|UniProtKB=A0A9J7L838	Branchiostoma floridae	O
BRAFL\|Gene=LOC118416741\|UniProtKB=A0A9J7MSU0	Branchiostoma floridae	O
BRAFL\|Gene=LOC118403942\|UniProtKB=A0A9J7KHC9	Branchiostoma floridae	O
BRAFL\|Gene=LOC118430558\|UniProtKB=A0A9J7MAM1	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC754774\|UniProtKB=A0A7M7NXL8	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00019487\|UniProtKB=Q965J0	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG23957\|UniProtKB=A8WJN7	Caenorhabditis briggsae	O
DROME\|FlyBase=FBgn0261547\|UniProtKB=Q9VVC6	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP007452\|UniProtKB=A0A1S4GV52	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC006316\|UniProtKB=D6WW23	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC011886\|UniProtKB=D6WZ80	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_43086\|UniProtKB=E9FZ04	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW001487\|UniProtKB=B7P264	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g168046\|UniProtKB=A7S9L2	Nematostella vectensis	O
MONBE\|EnsemblGenome=MONBRDRAFT_34077\|UniProtKB=A9V9C3	Monosiga brevicollis	O
TRIV3\|Gene_ORFName=TVAG_463700\|UniProtKB=A2E223	Trichomonas vaginalis	O