PANTHER Gene Information   
Gene Symbol(s): Elane
Organism: Mus musculus
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Gene Name: Neutrophil elastase
Gene ID: MGI:2679229
Protein ID: Q3UP87
Persistent Id: PTN000666612
Alternate Ids:
U04962(EMBL) ENSMUST00000046091(Ensembl_TRS)
MGI:2679229(MGI) Elane(Symbol)
148699689(GI) 3.4.21.37(EC)
BAE25510(EMBL-CDS) ENSMUSG00000020125(Ensembl)
A6H698(AltAccession) ELNE_MOUSE(UniProtKB-ID)
50701(GeneID) NP_056594(refSeq)
CHEMBL5156(ChEMBL) ENSMUSP00000038925(Ensembl_PRO)
Leukocyte elastase(Synonym)
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PANTHER Classification
PANTHER Family: CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER (PTHR24257)
PANTHER Subfamily: NEUTROPHIL ELASTASE (PTHR24257:SF16)  
PANTHER GO-slim Molecular Function: serine-type endopeptidase activity
PANTHER GO-slim Biological Process: immune response
acute inflammatory response
proteolysis
phagocytosis
PANTHER GO-slim Cellular Component: extracellular space
PANTHER protein class: serine protease
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: transcription corepressor activity, endopeptidase activity, serine-type endopeptidase activity, protease binding, heparin binding, peptidase activity, cytokine binding
GO BP Complete: neutrophil-mediated killing of fungus, negative regulation of chemokine production, positive regulation of leukocyte tethering or rolling, response to UV, defense response to bacterium, negative regulation of transcription by RNA polymerase II, positive regulation of smooth muscle cell proliferation, leukocyte migration involved in inflammatory response, positive regulation of interleukin-8 production, acute inflammatory response to antigenic stimulus, biosynthetic process of antibacterial peptides active against Gram-negative bacteria, response to yeast, negative regulation of interleukin-8 production, proteolysis, phagocytosis, response to lipopolysaccharide, leukocyte migration, defense response to fungus, positive regulation of immune response, neutrophil-mediated killing of gram-negative bacterium
GO CC Complete: extracellular space, cytoplasm, transcription repressor complex, secretory granule, collagen-containing extracellular matrix, Golgi apparatus, cell surface
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Programmed Cell Death, Immune System, Extracellular matrix organization, Innate Immune System, Pyroptosis, Neutrophil degranulation, Antimicrobial peptides, Degradation of the extracellular matrix, Complement cascade, Activation of Matrix Metalloproteinases, Regulation of Complement cascade, Regulated Necrosis

Orthologs