PANTHER Gene Information

Gene Symbol(s):

Irak4

Organism:

Mus musculus

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Gene Name:

Interleukin-1 receptor-associated kinase 4

Gene ID:

MGI:2182474

Protein ID:

Q8R4K2

Persistent Id:

PTN000701367

Alternate Ids:

Irak4(Symbol)	AAH51676(EMBL-CDS)
MGI:2182474(MGI)	IRAK4(Synonym)
Q80WW1(AltAccession)	IRAK4_MOUSE(UniProtKB-ID)
266632(GeneID)	NM_029926(refSeq)
159163344(GI)	2.7.11.1(EC)
ENSMUSP00000074471(Ensembl_PRO)	ENSMUSG00000059883(Ensembl)
BC051676(EMBL)	CHEMBL4630844(ChEMBL)
ENSMUST00000074936(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE (PTHR24419)
PANTHER Subfamily:	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 (PTHR24419:SF35)
PANTHER GO-slim Molecular Function:	protein serine/threonine kinase activity histone modifying activity
PANTHER GO-slim Biological Process:	intracellular signal transduction mitotic cell cycle cellular response to lipopolysaccharide cytokine-mediated signaling pathway positive regulation of canonical NF-kappaB signal transduction
PANTHER GO-slim Cellular Component:	plasma membrane cytoplasm nucleus
PANTHER protein class:	non-receptor serine/threonine protein kinase

Pathway Categories:

Toll receptor signaling pathway

IRAK4

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	magnesium ion binding, ribosomal protein S6 kinase activity, DNA-dependent protein kinase activity, ATP binding, histone H2AT120 kinase activity, AMP-activated protein kinase activity, histone H3S57 kinase activity, histone H4S1 kinase activity, histone H3S28 kinase activity, histone H3T45 kinase activity, histone H2AXS139 kinase activity, protein serine kinase activity, protein kinase binding, histone H3S10 kinase activity, histone H2BS14 kinase activity, histone H2AS1 kinase activity, eukaryotic translation initiation factor 2alpha kinase activity, protein serine/threonine kinase activity, 3-phosphoinositide-dependent protein kinase activity, interleukin-1 receptor binding, protein binding, histone H2AS121 kinase activity, histone H3T3 kinase activity, histone H2BS36 kinase activity, Rho-dependent protein serine/threonine kinase activity, kinase activity, histone H3T11 kinase activity, histone H3T6 kinase activity
GO BP Complete:	Toll signaling pathway, interleukin-33-mediated signaling pathway, positive regulation of canonical NF-kappaB signal transduction, JNK cascade, positive regulation of smooth muscle cell proliferation, neutrophil migration, neutrophil mediated immunity, chromatin remodeling, cytokine-mediated signaling pathway, innate immune response, lipopolysaccharide-mediated signaling pathway, cytokine production, interleukin-1-mediated signaling pathway, intracellular signal transduction
GO CC Complete:	nucleus, extracellular space, cytoplasm, plasma membrane, cell surface

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Immune System, Interleukin-1 signaling, Negative regulation of the PI3K/AKT network, Signal Transduction, Interleukin-1 family signaling, Intracellular signaling by second messengers, Signaling by Interleukins, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, Cytokine Signaling in Immune system, PIP3 activates AKT signaling

Orthologs

ID	Organism	Type
HUMAN\|HGNC=17967\|UniProtKB=Q9NWZ3	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000004845.4\|UniProtKB=H2Q5R2	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000008989.3\|UniProtKB=G3RYR9	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000000204.4\|UniProtKB=F7HHC6	Macaca mulatta	LDO
RAT\|RGD=1305303\|UniProtKB=A0A8I6G1H3	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000021105\|UniProtKB=Q1RMT8	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000000799.6\|UniProtKB=F6Q7E6	Sus scrofa	LDO
FELCA\|Ensembl=ENSFCAG00000021974.4\|UniProtKB=A0A337S8S7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845029210.1\|UniProtKB=A0A8I3Q059	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000018536.3\|UniProtKB=F7GD74	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000001905.3\|UniProtKB=A0A6I8NR41	Ornithorhynchus anatinus	LDO
ANOCA\|Ensembl=ENSACAG00000002988.4\|UniProtKB=G1KBF6	Anolis carolinensis	LDO
CIOIN\|Ensembl=ENSCING00000007470.3\|UniProtKB=F6YIF4	Ciona intestinalis	LDO
STRPU\|EnsemblGenome=LOC577165\|UniProtKB=A0A7M7HMP9	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00004029\|UniProtKB=G5ECP4	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG01770\|UniProtKB=A8WQV8	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00106112\|UniProtKB=A0A2A6CBA4	Pristionchus pacificus	LDO
ANOGA\|EnsemblGenome=AGAP003062\|UniProtKB=A0NDA5	Anopheles gambiae	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_314397\|UniProtKB=E9G601	Daphnia pulex	O
DROME\|FlyBase=FBgn0010441\|UniProtKB=Q05652	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP002966\|UniProtKB=Q7QD54	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC015365\|UniProtKB=D2A4G0	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_331814\|UniProtKB=E9HNI1	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW001463\|UniProtKB=B7P466	Ixodes scapularis	LDO
TRIAD\|EnsemblGenome=TriadG51557\|UniProtKB=B3RJR3	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG56727\|UniProtKB=B3RWF2	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG51564\|UniProtKB=B3RJS0	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG56779\|UniProtKB=B3RWK2	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG51561\|UniProtKB=B3RJR7	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG51559\|UniProtKB=B3RJR5	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG56391\|UniProtKB=B3RY03	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG56775\|UniProtKB=B3RWJ8	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG56777\|UniProtKB=B3RWK0	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG56776\|UniProtKB=B3RWJ9	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG56729\|UniProtKB=B3RWF4	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG56778\|UniProtKB=B3RWK1	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG51556\|UniProtKB=B3RJR2	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG56774\|UniProtKB=B3RWJ7	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_29201\|UniProtKB=A9VAE8	Monosiga brevicollis	O
YEAST\|SGD=S000002989\|UniProtKB=P43633	Saccharomyces cerevisiae	O
YEAST\|SGD=S000000105\|UniProtKB=P32789	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_AFR492W\|UniProtKB=Q752T1	Eremothecium gossypii	O
YARLI\|EnsemblGenome=YALI0_A00506g\|UniProtKB=Q6CI93	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_02054\|UniProtKB=Q5BBM6	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_4G09970\|UniProtKB=Q4WPP3	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU00407\|UniProtKB=Q7RYQ3	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_09672\|UniProtKB=A7EWG3	Sclerotinia sclerotiorum	O
PHANO\|Gene_ORFName=SNOG_10792\|UniProtKB=Q0UBS2	Phaeosphaeria nodorum	O
PHANO\|EnsemblGenome=SNOG_09573\|UniProtKB=Q0UF91	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC23C4.03\|UniProtKB=O13924	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_00678\|UniProtKB=B6JWA5	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CND04490\|UniProtKB=Q5KI22	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_00810\|UniProtKB=A0A0D1EB32	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_21214\|UniProtKB=H6QQN1	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_87100\|UniProtKB=F4NXQ4	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_125360\|UniProtKB=C4M627	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0286465\|UniProtKB=Q54LU8	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_98694\|UniProtKB=F0ZSR1	Dictyostelium purpureum	O
CHLRE\|EnsemblGenome=CHLRE_02g108000v5\|UniProtKB=A0A2K3E2U0	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00045p00081020\|UniProtKB=W1NWH6	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_291G00140\|UniProtKB=A0A0K9PEH2	Zostera marina	O
MUSAM\|EnsemblGenome=Ma11_g04570\|UniProtKB=A0A804L477	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_029328mg\|UniProtKB=K3ZRU8	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3002G390700\|UniProtKB=A0A1W0W7H0	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb109970\|UniProtKB=B6TIJ0	Zea mays	O
BRADI\|EnsemblGenome=BRADI_1g20067v3\|UniProtKB=A0A2K2DK66	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0120900\|UniProtKB=A0A8I7B588	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS2D02G154700\|UniProtKB=A0A3B6DC03	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2A02G149600\|UniProtKB=A0A3B6AUM8	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2B02G174700\|UniProtKB=A0A3B6C1X6	Triticum aestivum	O
NELNU\|Gene=LOC104588620\|UniProtKB=A0A1U7YZ92	Nelumbo nucifera	O
NELNU\|Gene_ORFName=HUJ06_009069\|UniProtKB=A0A1U8AT13	Nelumbo nucifera	O
SPIOL\|Gene=LOC110797253\|UniProtKB=A0A9R0J176	Spinacia oleracea	O
HELAN\|Gene_ORFName=HanXRQr2_Chr14g0653261\|UniProtKB=A0A9K3EB08	Helianthus annuus	O
HELAN\|Gene_ORFName=HannXRQ_Chr14g0449401\|UniProtKB=A0A251SIW7	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C900488910\|UniProtKB=A0A9R1WUG8	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a027116mg\|UniProtKB=A0A022PYS2	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_33618\|UniProtKB=A0A2G2XYH0	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400018290\|UniProtKB=M1BK60	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc01g101110.3\|UniProtKB=A0A3Q7EPA6	Solanum lycopersicum	O
TOBAC\|Gene=NtHaspin\|UniProtKB=A0A146F677	Nicotiana tabacum	O
TOBAC\|Gene=LOC107787031\|UniProtKB=A0A1S3ZIE2	Nicotiana tabacum	O
VITVI\|Gene_OrderedLocusName=VIT_14s0060g00450\|UniProtKB=F6I4H2	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_B01816\|UniProtKB=A0A059D3L7	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00047166001\|UniProtKB=A0A078H025	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00051577001\|UniProtKB=A0A078H5U9	Brassica napus	O
ARATH\|TAIR=locus=2012340\|UniProtKB=O80528	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107918718\|UniProtKB=A0A1U8KMT6	Gossypium hirsutum	O
GOSHI\|Gene=LOC107893736\|UniProtKB=A0A1U8I7T0	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_026831\|UniProtKB=A0A061F365	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g013230mg\|UniProtKB=A0A067DS29	Citrus sinensis	O
POPTR\|Gene_ORFName=POPTR_005G003400\|UniProtKB=A0A3N7G7F8	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_09G180400\|UniProtKB=A0A251K864	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1436590\|UniProtKB=B9RFQ3	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_19G226000\|UniProtKB=K7MZR6	Glycine max	O
MEDTR\|EnsemblGenome=MTR_7g111610\|UniProtKB=G7KWG0	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr11_04800\|UniProtKB=A0A2I4EAL1	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_1G560690\|UniProtKB=A0A0A0LVR4	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_6G305800\|UniProtKB=A0A251P1C0	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_124914\|UniProtKB=D8SUA0	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c5_21110\|UniProtKB=A0A2K1KKI8	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0101s0065\|UniProtKB=A0A2R6WEK0	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_000910190\|UniProtKB=A0A1Y1HXA7	Klebsormidium nitens	O