PANTHER Gene Information

Gene Symbol(s):

Tmc2

Organism:

Mus musculus

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Gene Name:

Transmembrane channel-like protein 2

Gene ID:

MGI:2151017

Protein ID:

Q8R4P4

Persistent Id:

PTN000592041

Alternate Ids:

Q7TQB1(AltAccession)	NM_138655(refSeq)
MGI:2151017(MGI)	TMC2_MOUSE(UniProtKB-ID)
19223985(GI)	192140(GeneID)
Transmembrane cochlear-expressed protein 2(Synonym)	ENSMUSP00000125843(Ensembl_PRO)
ENSMUST00000166774(Ensembl_TRS)	Tmc2(Symbol)
AAP35264(EMBL-CDS)	AY263156(EMBL)
ENSMUSG00000060332(Ensembl)
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PANTHER Classification

PANTHER Family:	TRANSMEMBRANE CHANNEL-RELATED (PTHR23302)
PANTHER Subfamily:	TRANSMEMBRANE CHANNEL-LIKE PROTEIN 2 (PTHR23302:SF17)
PANTHER GO-slim Molecular Function:	monoatomic ion channel activity gated channel activity
PANTHER GO-slim Biological Process:	sensory perception of sound detection of mechanical stimulus detection of stimulus involved in sensory perception
PANTHER GO-slim Cellular Component:
PANTHER protein class:	ion channel

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	mechanosensitive monoatomic ion channel activity, protein binding, calcium channel activity, voltage-gated calcium channel activity
GO BP Complete:	regulation of calcium ion transmembrane transport, calcium ion transmembrane transport, detection of mechanical stimulus involved in sensory perception of sound, vestibular reflex
GO CC Complete:	stereocilium, stereocilium tip, cuticular plate, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=16527\|UniProtKB=Q8TDI7	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000013178.5\|UniProtKB=H2R1A8	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000007013.3\|UniProtKB=G3QVT6	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000013889.4\|UniProtKB=F6R530	Macaca mulatta	LDO
RAT\|RGD=1310073\|UniProtKB=D4A3U8	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000018811.6\|UniProtKB=F1MW07	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000007172.5\|UniProtKB=F1S898	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000010161.4\|UniProtKB=F6R023	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000014449.6\|UniProtKB=A0A2I2U085	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845016638.1\|UniProtKB=A0A8I3NVN7	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000010987.3\|UniProtKB=F7APF5	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000003586.3\|UniProtKB=F7D6A7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010015934.1\|UniProtKB=A0A8V0YTZ8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000004125.3\|UniProtKB=H9G8K6	Anolis carolinensis	LDO
XENLA\|Gene=LOC108695514\|UniProtKB=A0A8J0T8K5	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-6050839\|UniProtKB=A0A8J0QQC5	Xenopus tropicalis	O
XENLA\|Gene=LOC108705264\|UniProtKB=A0A8J1L1U2	Xenopus laevis	O
XENLA\|Gene=LOC108718502\|UniProtKB=A0A8J0VJ78	Xenopus laevis	LDO
XENTR\|Gene=LOC116411739\|UniProtKB=A0A8J1JV22	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000012327.2\|UniProtKB=H2MA81	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-060526-262\|UniProtKB=F1QZE9	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000013590.2\|UniProtKB=H2MEN4	Oryzias latipes	LDO
DANRE\|Gene=tmc2a\|UniProtKB=E7FFT2	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000009603.1\|UniProtKB=W5MTM7	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000000728.3\|UniProtKB=F6WWM2	Ciona intestinalis	O
BRAFL\|Gene=LOC118421167\|UniProtKB=A0A9J7LJS7	Branchiostoma floridae	O
BRAFL\|Gene=LOC118420432\|UniProtKB=A0A9J7MVP0	Branchiostoma floridae	O
CAEEL\|WormBase=WBGene00015177\|UniProtKB=Q11069	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG16163\|UniProtKB=A8XNZ4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00089811\|UniProtKB=A0A2A6BG32	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00020490\|UniProtKB=D3KZG3	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG04140\|UniProtKB=A8WVN4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00089810\|UniProtKB=A0A2A6BF17	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0267796\|UniProtKB=A0A0U1QT59	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP007628\|UniProtKB=A0A1S4GVQ2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC032517\|UniProtKB=A0A139WL35	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_63207\|UniProtKB=E9HIT7	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_319521\|UniProtKB=E9GM03	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW019054\|UniProtKB=B7PPH9	Ixodes scapularis	O
TRIAD\|EnsemblGenome=TriadG63632\|UniProtKB=B3RNG7	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_4964\|UniProtKB=A9UPH3	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_10475\|UniProtKB=A9V6B0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_6695\|UniProtKB=A9UV08	Monosiga brevicollis	O
SELML\|EnsemblGenome=SELMODRAFT_430643\|UniProtKB=D8TA18	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_431105\|UniProtKB=D8TBJ2	Selaginella moellendorffii	O
MARPO\|EnsemblGenome=MARPO_0012s0021\|UniProtKB=A0A2R6XJ18	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_000200270\|UniProtKB=A0A1Y1HJZ3	Klebsormidium nitens	O