PANTHER Gene Information

Gene Symbol(s):

Dock10

Organism:

Mus musculus

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Gene Name:

Dedicator of cytokinesis protein 10

Gene ID:

MGI:2146320

Protein ID:

Q8BZN6

Persistent Id:

PTN000594187

Alternate Ids:

XP_006496538(refSeq)	26329657(GI)
Dock10{ECO:0000312\|MGI:MGI:2146320}(Symbol)	AK122347(EMBL)
210293(GeneID)	Ziz3(Synonym)
BAC28567(EMBL-CDS)	A0A087WQ86(AltAccession)
MGI:2146320(MGI)	ENSMUSG00000038608(Ensembl)
DOC10_MOUSE(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	DEDICATOR OF CYTOKINESIS DOCK (PTHR23317)
PANTHER Subfamily:	DEDICATOR OF CYTOKINESIS PROTEIN 10 (PTHR23317:SF71)
PANTHER GO-slim Molecular Function:	guanyl-nucleotide exchange factor activity
PANTHER GO-slim Biological Process:	positive regulation of GTPase activity regulation of cell migration dendritic spine morphogenesis
PANTHER GO-slim Cellular Component:
PANTHER protein class:	guanyl-nucleotide exchange factor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	guanyl-nucleotide exchange factor activity, small GTPase binding
GO BP Complete:	regulation of Rho protein signal transduction, marginal zone B cell differentiation, small GTPase-mediated signal transduction, regulation of postsynapse assembly, regulation of cell migration, B cell homeostasis, positive regulation of GTPase activity, dendritic spine morphogenesis
GO CC Complete:	nucleus, postsynapse, cytoplasm, dendritic spine, cytosol, glutamatergic synapse, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Signaling by Rho GTPases, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Hemostasis, RHO GTPase cycle, RAC2 GTPase cycle, Factors involved in megakaryocyte development and platelet production, RAC1 GTPase cycle, CDC42 GTPase cycle, RAC3 GTPase cycle

Orthologs

ID	Organism	Type
HUMAN\|HGNC=23479\|UniProtKB=Q96BY6	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000012987.6\|UniProtKB=H2QJJ2	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000007899.3\|UniProtKB=A0A2I2YXF0	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000018139.4\|UniProtKB=A0A5F7ZFR4	Macaca mulatta	LDO
RAT\|RGD=1561963\|UniProtKB=A0A8I6ADN8	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000000581.6\|UniProtKB=E1B7C4	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000016237.5\|UniProtKB=F1SNP7	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000000357.4\|UniProtKB=F7DV35	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000008146.6\|UniProtKB=A0A2I2U6X7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845014892.1\|UniProtKB=A0A8I3NVB3	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000021205.5\|UniProtKB=F6UH53	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000003576.4\|UniProtKB=F7DG76	Ornithorhynchus anatinus	LDO
ANOCA\|Ensembl=ENSACAG00000003851.4\|UniProtKB=A0A803TTX4	Anolis carolinensis	LDO
XENLA\|Gene=dock10.S\|UniProtKB=A0A8J1KU82	Xenopus laevis	O
XENLA\|Gene=dock10.L\|UniProtKB=A0A8J1KPS5	Xenopus laevis	LDO
XENTR\|Gene=dock10\|UniProtKB=A0A8J1JMJ6	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000007342.2\|UniProtKB=H2LSZ8	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-130530-773\|UniProtKB=X1WF60	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000003862.1\|UniProtKB=W5M8G1	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000002933.3\|UniProtKB=F7BIX8	Ciona intestinalis	O
BRAFL\|Gene=LOC118428192\|UniProtKB=A0A9J7M4H7	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC587687\|UniProtKB=A0A7M7NN01	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00009065\|UniProtKB=A0A0K3AR51	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG04359\|UniProtKB=A8WXC6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00114914\|UniProtKB=A0A8R1YPV2	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0260486\|UniProtKB=M9PCG3	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP008535\|UniProtKB=A0A1S4GZB0	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC013407\|UniProtKB=A0A139WGV9	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_197198\|UniProtKB=E9GKX3	Daphnia pulex	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g241086\|UniProtKB=A7RW14	Nematostella vectensis	O
MONBE\|EnsemblGenome=MONBRDRAFT_28379\|UniProtKB=A9V803	Monosiga brevicollis	O
ENTH1\|EnsemblGenome=EHI_106260\|UniProtKB=B1N3J3	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_179090\|UniProtKB=B1N2M9	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_117860\|UniProtKB=C4LYX0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_114220\|UniProtKB=C4M429	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_170180\|UniProtKB=C4M1E0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_124390\|UniProtKB=C4LZH5	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_151250\|UniProtKB=C4LSG8	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_147440\|UniProtKB=C4M6M0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_184500\|UniProtKB=C4M6S5	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_017610\|UniProtKB=C4M3G6	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_064100\|UniProtKB=C4MB52	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_185270\|UniProtKB=C4M3Z5	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_120630\|UniProtKB=C4M8X4	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0275239\|UniProtKB=Q554I8	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_152501\|UniProtKB=F0ZLI8	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0268888\|UniProtKB=Q55EI2	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_149722\|UniProtKB=F0ZEH9	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0293084\|UniProtKB=Q54CA8	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_153700\|UniProtKB=F0ZPJ5	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0275035\|UniProtKB=Q86I66	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_151994\|UniProtKB=F0ZK81	Dictyostelium purpureum	O
GIAIC\|EnsemblGenome=GL50803_114201\|UniProtKB=D3KHS6	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_114209\|UniProtKB=D3KHS5	Giardia intestinalis	O
THAPS\|EnsemblGenome=THAPSDRAFT_24231\|UniProtKB=B8C9T4	Thalassiosira pseudonana	O
PHYRM\|Gene=H3H0P4_PHYRM\|UniProtKB=H3H0P4	Phytophthora ramorum	O
AMBTC\|EnsemblGenome=AMTR_s00119p00032770\|UniProtKB=W1NQU1	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_31G00920\|UniProtKB=A0A0K9P947	Zostera marina	O
SETIT\|EnsemblGenome=SETIT_033859mg\|UniProtKB=K4A4Q5	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3001G385400\|UniProtKB=A0A1B6QNI5	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb395310\|UniProtKB=A0A804R8H3	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb015660\|UniProtKB=A0A804LJL2	Zea mays	O
BRADI\|EnsemblGenome=BRADI_3g31490v3\|UniProtKB=A0A0Q3FEA1	Brachypodium distachyon	O
BRADI\|EnsemblGenome=BRADI_5g24268v3\|UniProtKB=A0A0Q3P7M1	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.4HG0379540\|UniProtKB=A0A287P0Q5	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS4D02G175600\|UniProtKB=A0A3B6JIE0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4B02G173500\|UniProtKB=A0A3B6ISU1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS4A02G131100\|UniProtKB=A0A3B6HR55	Triticum aestivum	O
NELNU\|Gene=LOC104612756\|UniProtKB=A0A1U8BF44	Nelumbo nucifera	O
SPIOL\|Gene=LOC110803825\|UniProtKB=A0A9R0KAU5	Spinacia oleracea	O
HELAN\|Gene_ORFName=HannXRQ_Chr17g0541121\|UniProtKB=A0A251RM55	Helianthus annuus	O
HELAN\|Gene_ORFName=HanXRQr2_Chr17g0789521\|UniProtKB=A0A9K3DFI0	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr06g0248331\|UniProtKB=A0A251UGI0	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C300115480\|UniProtKB=A0A9R1WA66	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a000090mg\|UniProtKB=A0A022QR57	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_03426\|UniProtKB=A0A2G3AMT8	Capsicum annuum	O
SOLLC\|EnsemblGenome=Solyc08g016050.3\|UniProtKB=A0A3Q7HJB0	Solanum lycopersicum	O
TOBAC\|Gene=LOC107798217\|UniProtKB=A0A1S4AJ05	Nicotiana tabacum	O
TOBAC\|Gene=LOC107786741\|UniProtKB=A0A1S3ZH84	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi11g00005\|UniProtKB=D7TC76	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_K02348\|UniProtKB=A0A059A4U2	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00056544001\|UniProtKB=A0A078H9M1	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00051674001\|UniProtKB=A0A078H0L2	Brassica napus	O
BRACM\|EnsemblGenome=Bra038448\|UniProtKB=M4FBI2	Brassica campestris	O
ARATH\|TAIR=locus=2130484\|UniProtKB=Q8SAB7	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107946479\|UniProtKB=A0A1U8NED2	Gossypium hirsutum	O
GOSHI\|Gene=LOC107938242\|UniProtKB=A0A1U8MJ22	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_011918\|UniProtKB=A0A061EB78	Theobroma cacao	O
POPTR\|EnsemblGenome=POPTR_011G024000v3\|UniProtKB=B9HZJ9	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_17G018400\|UniProtKB=A0A251IU11	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1244720\|UniProtKB=B9RSI5	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_15G212800\|UniProtKB=K7MCT0	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_08G148300\|UniProtKB=K7L6S8	Glycine max	O
MEDTR\|EnsemblGenome=MTR_8g056900\|UniProtKB=G7LB13	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr02_08460\|UniProtKB=A0A2I4GVI2	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_7G238980\|UniProtKB=A0A0A0K3K4	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_4G132800\|UniProtKB=M5X3A7	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_449303\|UniProtKB=D8TER0	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_129262\|UniProtKB=D8T0J7	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c15_8680\|UniProtKB=A0A2K1JCI1	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c4_25310\|UniProtKB=A0A2K1KPX4	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c3_15370\|UniProtKB=A0A2K1KUK9	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c9_15160\|UniProtKB=A0A7I4FVQ4	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c10_16640\|UniProtKB=A0A7I4EYY2	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c1_25190\|UniProtKB=A0A7I4C0U7	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0021s0072\|UniProtKB=A0A2R6XDN5	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_000980070\|UniProtKB=A0A0U9HRY0	Klebsormidium nitens	O