PANTHER Gene Information   
Gene Symbol(s): Prkaa1
Organism: Mus musculus
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Gene Name: 5'-AMP-activated protein kinase catalytic subunit alpha-1
Gene ID: MGI:2145955
Protein ID: Q5EG47
Persistent Id: PTN000679413
Alternate Ids:
105787(GeneID) CHEMBL1075161(ChEMBL)
MGI:2145955(MGI) ENSMUSP00000063166(Ensembl_PRO)
NP_001013385(refSeq) AAPK1_MOUSE(UniProtKB-ID)
94681061(GI) 2.7.11.1 {ECO:0000250|UniProtKB:P54645}(EC)
AAW79567(EMBL-CDS) ENSMUSG00000050697(Ensembl)
ENSMUST00000051186(Ensembl_TRS) AY885266(EMBL)
AAPK1(Synonym) Prkaa1(Symbol)
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PANTHER Classification
PANTHER Family: SERINE/THREONINE KINASE (PTHR24343)
PANTHER Subfamily: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 (PTHR24343:SF306)  
PANTHER GO-slim Molecular Function: protein serine/threonine kinase activity
PANTHER GO-slim Biological Process: cellular response to starvation
protein phosphorylation
negative regulation of TOR signaling
PANTHER GO-slim Cellular Component: cytoplasm
protein kinase complex
nucleus
intracellular protein-containing complex
PANTHER protein class: non-receptor serine/threonine protein kinase
Pathway Categories: Gonadotropin-releasing hormone receptor pathway
   AMPK
p53 pathway by glucose deprivation
   AMP-activated protein kinase
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein-containing complex binding, ribosomal protein S6 kinase activity, DNA-dependent protein kinase activity, ATP binding, histone H2AT120 kinase activity, AMP-activated protein kinase activity, histone H3S57 kinase activity, histone H4S1 kinase activity, histone H3S28 kinase activity, histone H3T45 kinase activity, histone H2AXS139 kinase activity, kinase binding, protein serine kinase activity, histone H3S10 kinase activity, histone H2BS14 kinase activity, histone H2AS1 kinase activity, protein kinase activity, eukaryotic translation initiation factor 2alpha kinase activity, chromatin binding, protein serine/threonine kinase activity, 3-phosphoinositide-dependent protein kinase activity, protein binding, histone H2AS121 kinase activity, metal ion binding, [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity, histone H3T3 kinase activity, histone H2BS36 kinase activity, Rho-dependent protein serine/threonine kinase activity, histone H3T11 kinase activity, histone H3T6 kinase activity
GO BP Complete: response to estrogen, positive regulation of adipose tissue development, cold acclimation, glucose metabolic process, regulation of stress granule assembly, cellular response to prostaglandin E stimulus, positive regulation of T cell activation, positive regulation of skeletal muscle tissue development, positive regulation of DNA-templated transcription, cellular response to glucose stimulus, autophagy, positive regulation of peptidyl-lysine acetylation, energy homeostasis, Wnt signaling pathway, regulation of peptidyl-serine phosphorylation, cellular response to hypoxia, response to gamma radiation, negative regulation of TOR signaling, negative regulation of lipid catabolic process, CAMKK-AMPK signaling cascade, negative regulation of TORC1 signaling, cholesterol biosynthetic process, response to hydrogen peroxide, negative regulation of insulin receptor signaling pathway, cellular response to glucose starvation, negative regulation of tubulin deacetylation, cellular response to ethanol, positive regulation of autophagy, negative regulation of gene expression, positive regulation of T cell mediated immune response to tumor cell, cellular response to nutrient levels, fatty acid oxidation, positive regulation of gene expression, glucose homeostasis, response to activity, regulation of microtubule cytoskeleton organization, positive regulation of cell population proliferation, response to UV, regulation of vesicle-mediated transport, protein phosphorylation, regulation of circadian rhythm, positive regulation of glycolytic process, negative regulation of hepatocyte apoptotic process, positive regulation of mitochondrial transcription, chromatin remodeling, cellular response to calcium ion, cellular response to hydrogen peroxide, fatty acid homeostasis, lipid biosynthetic process, fatty acid biosynthetic process, motor behavior, positive regulation of protein targeting to mitochondrion, protein localization to lipid droplet, positive regulation of protein localization, neuron cellular homeostasis, rhythmic process, negative regulation of apoptotic process, cellular response to oxidative stress, response to caffeine, cellular response to xenobiotic stimulus, lipid droplet disassembly
GO CC Complete: nucleus, dendrite, cytoplasm, ciliary basal body, nuclear speck, cytosol, protein-containing complex, neuronal cell body, chromatin, apical plasma membrane, axon, nucleotide-activated protein kinase complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Regulation of TP53 Activity through Phosphorylation, Macroautophagy, Regulation of TP53 Activity, Signal Transduction, Autophagy, Transcriptional Regulation by TP53, TP53 Regulates Metabolic Genes, Generic Transcription Pathway, Energy dependent regulation of mTOR by LKB1-AMPK, MTOR signalling, Gene expression (Transcription), RNA Polymerase II Transcription

Orthologs