PANTHER Gene Information   
Gene Symbol(s): Pot1
Organism: Mus musculus
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Gene Name: Protection of telomeres protein 1
Gene ID: MGI:2141503
Protein ID: Q91WC1
Persistent Id: PTN000376554
Alternate Ids:
ENSMUSG00000029676(Ensembl) 26334011(GI)
BC016121(EMBL) Pot1(Symbol)
Pot1a(Synonym) AAH16121(EMBL-CDS)
MGI:2141503(MGI) 101185(GeneID)
Q8BUH9(AltAccession) POTE1_MOUSE(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: PROTECTION OF TELOMERES 1 (PTHR14513)
PANTHER Subfamily: PROTECTION OF TELOMERES PROTEIN 1 (PTHR14513:SF2)  
PANTHER GO-slim Molecular Function: single-stranded telomeric DNA binding
enzyme inhibitor activity
PANTHER GO-slim Biological Process: telomere capping
negative regulation of catalytic activity
regulation of transferase activity
negative regulation of macromolecule biosynthetic process
negative regulation of DNA metabolic process
regulation of telomere maintenance
PANTHER GO-slim Cellular Component: nuclear telomere cap complex
PANTHER protein class: DNA metabolism protein
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein binding, DEAD/H-box RNA helicase binding, telomeric DNA binding, 8-hydroxy-2'-deoxyguanosine DNA binding, G-rich single-stranded DNA binding, single-stranded telomeric DNA binding, G-rich strand telomeric DNA binding, telomerase inhibitor activity, telomeric D-loop binding
GO BP Complete: regulation of double-strand break repair via nonhomologous end joining, positive regulation of DNA strand elongation, telomere maintenance via telomerase, positive regulation of helicase activity, telomeric D-loop disassembly, chromosome organization, establishment of protein localization to telomere, positive regulation of telomere maintenance via telomerase, telomere assembly, regulation of telomere maintenance via telomerase, telomere capping, negative regulation of telomere maintenance via telomerase, positive regulation of telomere maintenance
GO CC Complete: chromosome, telomeric region, shelterin complex, nuclear telomere cap complex, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Cellular responses to stimuli, Inhibition of DNA recombination at telomere, Base-Excision Repair, AP Site Formation, DNA Repair, Base Excision Repair, Telomere Maintenance, Chromosome Maintenance, Extension of Telomeres, Telomere C-strand synthesis initiation, DNA Damage/Telomere Stress Induced Senescence, Cellular Senescence, Polymerase switching on the C-strand of the telomere, Recognition and association of DNA glycosylase with site containing an affected purine, Depurination, Processive synthesis on the C-strand of the telomere, Telomere Extension By Telomerase, Removal of the Flap Intermediate from the C-strand, Cleavage of the damaged purine, Cell Cycle, Cellular responses to stress, Telomere C-strand (Lagging Strand) Synthesis

Orthologs