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Gene Symbol(s):
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Dusp3
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| Organism: |
Mus musculus |
| View Gene in Tree |
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| Gene Name: |
Dual specificity protein phosphatase 3
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| Gene ID: |
MGI:1919599
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| Protein ID: |
Q9D7X3
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| Persistent Id: |
PTN000017230 |
| Alternate Ids: |
| 72349(GeneID) |
20137946(GI) |
| ENSMUSP00000003612(Ensembl_PRO) |
DUS3(Synonym) |
| ENSMUSG00000003518(Ensembl) |
AAH16269(EMBL-CDS) |
| NP_082483(refSeq) |
3.1.3.48(EC) |
| ENSMUST00000107172(Ensembl_TRS) |
BC016269(EMBL) |
| DUS3_MOUSE(UniProtKB-ID) |
Dusp3(Symbol) |
MGI:1919599(MGI) |
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Show All
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| GO MF Complete: |
protein kinase binding, calmodulin-dependent protein phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, protein tyrosine kinase binding, phosphoprotein phosphatase activity, MAP kinase phosphatase activity, non-membrane spanning protein tyrosine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine phosphatase activity, metal-dependent, phosphatase activity, RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity, RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity, MAP kinase serine/threonine phosphatase activity, cytoskeletal protein binding, histone H2AXS140 phosphatase activity, RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity, receptor tyrosine kinase binding, histone H2AXY142 phosphatase activity, RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity, myosin phosphatase activity, RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
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| GO BP Complete: |
negative regulation of MAPK cascade, protein dephosphorylation, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of JNK cascade, positive regulation of mitotic cell cycle, regulation of transcription by RNA polymerase II, peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity, chromatin remodeling, regulation of focal adhesion assembly, flagellated sperm motility, negative regulation of T cell receptor signaling pathway, in utero embryonic development, negative regulation of ERK1 and ERK2 cascade, cellular response to epidermal growth factor stimulus, negative regulation of chemotaxis, negative regulation of T cell activation, positive regulation of focal adhesion disassembly, dephosphorylation, peptidyl-tyrosine dephosphorylation, negative regulation of cell migration
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| GO CC Complete: |
nucleus, cytoplasm, cytosol, axonemal microtubule doublet inner sheath, sperm flagellum, immunological synapse, nucleoplasm
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| Reactome Pathways: |
Immune System, Toll Like Receptor TLR1:TLR2 Cascade, Signaling by Receptor Tyrosine Kinases, Toll Like Receptor 5 (TLR5) Cascade, Nuclear Events (kinase and transcription factor activation), Toll-like Receptor Cascades, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Interleukin-17 signaling, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, TRIF(TICAM1)-mediated TLR4 signaling , MAP kinase activation, Signaling by NTRK1 (TRKA), ERKs are inactivated, MyD88-independent TLR4 cascade , Toll Like Receptor TLR6:TLR2 Cascade, Innate Immune System, Signal Transduction, ERK/MAPK targets, Signaling by NTRKs, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, Toll Like Receptor 2 (TLR2) Cascade, MAPK targets/ Nuclear events mediated by MAP kinases, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, Signaling by Interleukins, Toll Like Receptor 7/8 (TLR7/8) Cascade, Cytokine Signaling in Immune system, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 3 (TLR3) Cascade
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