PANTHER Gene Information

Gene Symbol(s):

Tmbim1

Organism:

Mus musculus

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Gene Name:

Protein lifeguard 3

Gene ID:

MGI:1916910

Protein ID:

Q8BJZ3

Persistent Id:

PTN000591009

Alternate Ids:

MGI:1916910(MGI)	NP_081430(refSeq)
AB097685(EMBL)	LFG3(Synonym)
AAH04752(EMBL-CDS)	69660(GeneID)
Tmbim1(Symbol)	38503325(GI)
LFG3_MOUSE(UniProtKB-ID)	Q99KB6(AltAccession)
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PANTHER Classification

PANTHER Family:	BAX INHIBITOR-RELATED (PTHR23291)
PANTHER Subfamily:	PROTEIN LIFEGUARD 3 (PTHR23291:SF35)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:	negative regulation of apoptotic signaling pathway
PANTHER GO-slim Cellular Component:	Golgi apparatus membrane endoplasmic reticulum
PANTHER protein class:	ion channel

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	calcium channel activity, death receptor binding
GO BP Complete:	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of protein localization to plasma membrane, negative regulation of catalytic activity, positive regulation of blood vessel remodeling, negative regulation of Fas signaling pathway, regulation of calcium-mediated signaling, apoptotic signaling pathway, negative regulation of neuron apoptotic process
GO CC Complete:	intracellular membrane-bounded organelle, membrane, endoplasmic reticulum, Golgi apparatus, endosome membrane, lysosomal membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Immune System, Innate Immune System, Neutrophil degranulation

Orthologs

ID	Organism	Type
HUMAN\|HGNC=23410\|UniProtKB=Q969X1	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000012915.4\|UniProtKB=H2QJE5	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000006905.3\|UniProtKB=G3QVI6	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000022817.4\|UniProtKB=F6UPC8	Macaca mulatta	LDO
RAT\|RGD=1359409\|UniProtKB=Q6AYE0	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000003935.5\|UniProtKB=Q6QRN7	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000016186.5\|UniProtKB=A0A5G2RAH9	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000011922.3\|UniProtKB=A0A9L0R6H8	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000002374.6\|UniProtKB=M3VYE2	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845026892.1\|UniProtKB=A0A8I3PXA4	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000015501.3\|UniProtKB=F6WEN6	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000038099.1\|UniProtKB=A0A6I8PCU3	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010019127.1\|UniProtKB=A0A8V0Z2X0	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000001486.4\|UniProtKB=G1K9M1	Anolis carolinensis	LDO
XENLA\|Gene=tmbim1.L\|UniProtKB=A0A1L8EVR1	Xenopus laevis	O
XENLA\|Gene=tmbim1.S\|UniProtKB=Q5U596	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-984286\|UniProtKB=Q569D7	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000011243.2\|UniProtKB=H2M6J9	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000020503.2\|UniProtKB=H2N1T8	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-041010-69\|UniProtKB=X1WGS1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000000843.1\|UniProtKB=W5LXT7	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000007006.3\|UniProtKB=F7BIC8	Ciona intestinalis	O
BRAFL\|Gene=LOC118432766\|UniProtKB=A0A9J7MG91	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC582701\|UniProtKB=A0A7M7PKJ4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115919136\|UniProtKB=A0A7M7SSH2	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00006470\|UniProtKB=Q20241	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG19350\|UniProtKB=A8XVF1	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00021537\|UniProtKB=Q9N3Y5	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00035792\|UniProtKB=A8XME7	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00009580\|UniProtKB=Q8MQ55	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG04910\|UniProtKB=A8WYS5	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG19349\|UniProtKB=A8XVF0	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00099106\|UniProtKB=A0A8R1Y910	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00097622\|UniProtKB=A0A2A6CGX1	Pristionchus pacificus	O
TRICA\|EnsemblGenome=TC033069\|UniProtKB=A0A139WI54	Tribolium castaneum	O
IXOSC\|EnsemblGenome=ISCW003774\|UniProtKB=B7PH52	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG189986\|UniProtKB=T1FRK2	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g238030\|UniProtKB=A7RG77	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG60535\|UniProtKB=B3S8G8	Trichoplax adhaerens	O
ENTH1\|EnsemblGenome=CL6EHI_169290\|UniProtKB=C4M246	Entamoeba histolytica	O
PLAF7\|EnsemblGenome=PF3D7_1248500\|UniProtKB=Q8I4U9	Plasmodium falciparum	O
PARTE\|EnsemblGenome=GSPATT00005275001\|UniProtKB=A0BPQ8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00038235001\|UniProtKB=A0CG73	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00038624001\|UniProtKB=A0CJ75	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00013388001\|UniProtKB=A0D4F5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00003971001\|UniProtKB=A0ECT5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00039034001\|UniProtKB=A0CUW2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00031139001\|UniProtKB=A0BQU3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00029028001\|UniProtKB=A0BHH6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00018169001\|UniProtKB=A0DLD5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00022840001\|UniProtKB=A0E300	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00012504001\|UniProtKB=A0D1R3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00000858001\|UniProtKB=A0CK29	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00014770001\|UniProtKB=A0D9X1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00007216001\|UniProtKB=A0CDY7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00038836001\|UniProtKB=A0CQ12	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00029045001\|UniProtKB=A0BHJ3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00005842001\|UniProtKB=A0BZM3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00027274001\|UniProtKB=A0EI06	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00038270001\|UniProtKB=A0CGA8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00020588001\|UniProtKB=A0DV58	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00023706001\|UniProtKB=A0E6R1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00036620001\|UniProtKB=A0CAM2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00037302001\|UniProtKB=A0CCK0	Paramecium tetraurelia	O
CHLRE\|EnsemblGenome=CHLRE_01g035450v5\|UniProtKB=A8HM37	Chlamydomonas reinhardtii	O
STRR6\|EnsemblGenome=spr1787\|UniProtKB=Q8DNE4	Streptococcus pneumoniae	O
STAA8\|EnsemblGenome=SAOUHSC_00672\|UniProtKB=Q2G0D3	Staphylococcus aureus	O
LISMO\|Gene=Q8Y569_LISMO\|UniProtKB=Q8Y569	Listeria monocytogenes	O
BACSU\|EnsemblGenome=BSU_07200\|UniProtKB=O31539	Bacillus subtilis	O
DEIRA\|EnsemblGenome=DR_0893\|UniProtKB=Q9RVX8	Deinococcus radiodurans	O
GLOVI\|Gene=Q7NPB6_GLOVI\|UniProtKB=Q7NPB6	Gloeobacter violaceus	O
SYNY3\|Gene=P73793_SYNY3\|UniProtKB=P73793	Synechocystis	O
CHLTR\|EnsemblGenome=CT_819\|UniProtKB=O84826	Chlamydia trachomatis	O
RHOBA\|EnsemblGenome=RB3430\|UniProtKB=Q7UU92	Rhodopirellula baltica	O
FUSNN\|EnsemblGenome=FN0866\|UniProtKB=Q8RF52	Fusobacterium nucleatum	O
HELPY\|EnsemblGenome=HP_0920\|UniProtKB=O25578	Helicobacter pylori	O
NEIMB\|EnsemblGenome=NMB2020\|UniProtKB=P63702	Neisseria meningitidis serogroup b	O
HAEIN\|EnsemblGenome=HI_0044\|UniProtKB=P44477	Haemophilus influenzae	O
SHEON\|Gene_OrderedLocusName=SO_2375\|UniProtKB=Q8EEK6	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_1358\|UniProtKB=Q9KSA1	Vibrio cholerae	O
PSEAE\|EnsemblGenome=PA2604\|UniProtKB=Q03268	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM1085\|UniProtKB=Q8ZQ61	Salmonella typhimurium	O
ECOLI\|EnsemblGenome=BAA35735\|UniProtKB=P0AAC6	Escherichia coli	O
BRADU\|Gene=Q89X53_BRADU\|UniProtKB=Q89X53	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89DW5_BRADU\|UniProtKB=Q89DW5	Bradyrhizobium diazoefficiens	O
COXBU\|EnsemblGenome=CBU_0214\|UniProtKB=Q83EU5	Coxiella burnetii	O
SHEON\|Gene_OrderedLocusName=SO_0136\|UniProtKB=Q8EKF7	Shewanella oneidensis	O
PSEAE\|EnsemblGenome=PA1190\|UniProtKB=Q9I4E8	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM0807\|UniProtKB=Q8ZQP9	Salmonella typhimurium	O
YERPE\|Gene_OrderedLocusName=YPO1163\|UniProtKB=A0A2U2GWC9	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAA35444\|UniProtKB=P0AAC4	Escherichia coli	O