PANTHER Gene Information

Gene Symbol(s):

Chd8

Organism:

Mus musculus

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Gene Name:

Chromodomain-helicase-DNA-binding protein 8

Gene ID:

MGI:1915022

Protein ID:

Q09XV5

Persistent Id:

PTN000085648

Alternate Ids:

119392064(GI)	Duplin(Synonym)
XM_006519476(refSeq)	3.6.4.12 {ECO:0000255\|HAMAP-Rule:MF_03071}(EC)
ENSMUSG00000053754(Ensembl)	Q6ZPM8(AltAccession)
AY863219(EMBL)	BAE35730(EMBL-CDS)
67772(GeneID)	Chd8{ECO:0000255\|HAMAP-Rule:MF_03071}(Symbol)
CHD8_MOUSE(UniProtKB-ID)	MGI:1915022(MGI)
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PANTHER Classification

PANTHER Family:	CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED (PTHR45623)
PANTHER Subfamily:	CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 8 (PTHR45623:SF3)
PANTHER GO-slim Molecular Function:	ATP-dependent activity, acting on DNA chromatin binding ATP hydrolysis activity DNA binding histone binding
PANTHER GO-slim Biological Process:	tube development brain development negative regulation of canonical Wnt signaling pathway chromatin remodeling negative regulation of DNA-templated transcription
PANTHER GO-slim Cellular Component:	chromatin histone methyltransferase complex
PANTHER protein class:	chromatin/chromatin-binding, or -regulatory protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ATP hydrolysis activity, methylated histone binding, double-stranded DNA helicase activity, four-way junction helicase activity, chromatin binding, beta-catenin binding, forked DNA-dependent helicase activity, DNA binding, ATP binding, p53 binding, protein binding, histone binding, ATP-dependent chromatin remodeler activity, armadillo repeat domain binding, single-stranded 3'-5' DNA helicase activity
GO BP Complete:	social behavior, negative regulation of fibroblast apoptotic process, prepulse inhibition, mRNA processing, brain development, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, negative regulation of transcription by RNA polymerase II, negative regulation of canonical Wnt signaling pathway, chromatin remodeling, startle response, negative regulation of DNA-templated transcription, in utero embryonic development, positive regulation of DNA-templated transcription, digestive tract development, negative regulation of apoptotic process, Wnt signaling pathway, negative regulation of Wnt signaling pathway
GO CC Complete:	nucleus, protein-containing complex, chromatin, nucleoplasm, MLL1 complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Signaling by WNT, Deactivation of the beta-catenin transactivating complex, Signal Transduction, TCF dependent signaling in response to WNT

Orthologs

ID	Organism	Type
HUMAN\|HGNC=20153\|UniProtKB=Q9HCK8	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000006124.7\|UniProtKB=A0A2J8JI42	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000002251.3\|UniProtKB=A0A2I2ZB14	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000015002.4\|UniProtKB=F7GN20	Macaca mulatta	LDO
RAT\|RGD=620696\|UniProtKB=Q9JIX5	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000020422.5\|UniProtKB=F1MLB2	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000002127.5\|UniProtKB=A0A4X1UY74	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000016102.4\|UniProtKB=F6XQ51	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000013859.6\|UniProtKB=M3WJL6	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845026020.1\|UniProtKB=A0A8I3PP29	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000006219.4\|UniProtKB=F7FS88	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000041245.1\|UniProtKB=A0A6I8PB49	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010000350.1\|UniProtKB=A0A8V0X2U4	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000003139.4\|UniProtKB=H9G752	Anolis carolinensis	LDO
XENLA\|Gene=chd8.L\|UniProtKB=A0A8J0V5F4	Xenopus laevis	LDO
XENLA\|Gene=chd8.S\|UniProtKB=A0A8J0U9Q1	Xenopus laevis	O
ORYLA\|Ensembl=ENSORLG00000012103.2\|UniProtKB=H2M9G6	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030131-6320\|UniProtKB=B0R0I6	Danio rerio	LDO
BRAFL\|Gene=LOC118418283\|UniProtKB=A0A9J7LBX4	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC577327\|UniProtKB=A0A7M7N6P6	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00007053\|UniProtKB=O61845	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG22297\|UniProtKB=A8Y205	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00089825\|UniProtKB=A0A2A6CIG3	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0266557\|UniProtKB=B7Z002	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP008482\|UniProtKB=A0A453YTY9	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC014275\|UniProtKB=D6WL05	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_319863\|UniProtKB=E9GN21	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW018963\|UniProtKB=B7PKY0	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG149039\|UniProtKB=T1EKC3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG116695\|UniProtKB=T1EGH0	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g30104\|UniProtKB=A7RMN4	Nematostella vectensis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_35805\|UniProtKB=F4P8S6	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_000780\|UniProtKB=C4LZC7	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_115350\|UniProtKB=C4M8E6	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0293012\|UniProtKB=Q54CF8	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_53111\|UniProtKB=F0ZB73	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0280705\|UniProtKB=Q54UZ8	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_150076\|UniProtKB=F0ZFE1	Dictyostelium purpureum	O
TRIV3\|Gene_ORFName=TVAG_308180\|UniProtKB=A2EGL7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_286450\|UniProtKB=A2EPF9	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_387750\|UniProtKB=A2E102	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_035500\|UniProtKB=A2DAM4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_368250\|UniProtKB=A2FI37	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_382210\|UniProtKB=A2FNE0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_126300\|UniProtKB=A2ED18	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00005981001\|UniProtKB=A0C011	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00010887001\|UniProtKB=A0CVA2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00031325001\|UniProtKB=A0BRC7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00014719001\|UniProtKB=A0D9S1	Paramecium tetraurelia	O
PHYRM\|Gene=H3GJ31_PHYRM\|UniProtKB=H3GJ31	Phytophthora ramorum	O
PHYRM\|Gene=H3HCY4_PHYRM\|UniProtKB=H3HCY4	Phytophthora ramorum	O
PHYRM\|Gene=H3GTE0_PHYRM\|UniProtKB=H3GTE0	Phytophthora ramorum	O
PHYRM\|Gene=H3GEV6_PHYRM\|UniProtKB=H3GEV6	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_03g158550v5\|UniProtKB=A0A2K3DW75	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00039p00209870\|UniProtKB=U5D395	Amborella trichopoda	O
PHYPA\|EnsemblGenome=Pp3c15_6140\|UniProtKB=A0A2K1JC66	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c20_11500\|UniProtKB=A0A7I4BZ59	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0001s0194\|UniProtKB=A0A2R6XVM0	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_001250020\|UniProtKB=A0A1Y1I229	Klebsormidium nitens	O