PANTHER Gene Information

Gene Symbol(s):

Sharpin

Organism:

Mus musculus

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Gene Name:

Sharpin

Gene ID:

MGI:1913331

Protein ID:

Q91WA6

Persistent Id:

PTN000511663

Alternate Ids:

Q7TNT3(AltAccession)	BC016203(EMBL)
ENSMUSG00000022552(Ensembl)	27529931(GI)
Sharpin(Symbol)	BAC53796(EMBL-CDS)
106025(GeneID)	mSIPL1(Synonym)
SHRPN_MOUSE(UniProtKB-ID)	MGI:1913331(MGI)
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PANTHER Classification

PANTHER Family:	UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED (PTHR22770)
PANTHER Subfamily:	SHARPIN (PTHR22770:SF43)
PANTHER GO-slim Molecular Function:	ubiquitin-protein transferase activity ubiquitin binding
PANTHER GO-slim Biological Process:	proteasome-mediated ubiquitin-dependent protein catabolic process protein polyubiquitination positive regulation of canonical NF-kappaB signal transduction
PANTHER GO-slim Cellular Component:	ubiquitin ligase complex
PANTHER protein class:	ubiquitin-protein ligase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ubiquitin-protein transferase activity, zinc ion binding, identical protein binding, protein binding, ubiquitin binding, polyubiquitin modification-dependent protein binding, protein-macromolecule adaptor activity, protein-containing complex binding
GO BP Complete:	apoptotic nuclear changes, negative regulation of inflammatory response, epidermis development, positive regulation of canonical NF-kappaB signal transduction, negative regulation of canonical NF-kappaB signal transduction, canonical NF-kappaB signal transduction, defense response to bacterium, mitochondrion organization, tumor necrosis factor-mediated signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of tumor necrosis factor-mediated signaling pathway, protein linear polyubiquitination, keratinization, regulation of CD40 signaling pathway
GO CC Complete:	postsynaptic density, dendrite, cytosol, LUBAC complex, glutamatergic synapse

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=25321\|UniProtKB=Q9H0F6	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000020680.6\|UniProtKB=K7DSJ3	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000027471.2\|UniProtKB=G3RXU4	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000007152.4\|UniProtKB=F6X2J2	Macaca mulatta	LDO
RAT\|RGD=631353\|UniProtKB=Q9EQL9	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000012235\|UniProtKB=E1BDF2	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000005914.5\|UniProtKB=F1RSN0	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000002550.3\|UniProtKB=F6T279	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000011548.6\|UniProtKB=M3WFA6	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845008013.1\|UniProtKB=A0A8I3N2B0	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000010491.4\|UniProtKB=F7ES70	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000044056.1\|UniProtKB=A0A6I8NHM2	Ornithorhynchus anatinus	O
ANOCA\|Ensembl=ENSACAG00000008195.4\|UniProtKB=H9GDM4	Anolis carolinensis	O
ORYLA\|Ensembl=ENSORLG00000006036.2\|UniProtKB=H2LNF9	Oryzias latipes	O
LEPOC\|Ensembl=ENSLOCG00000006659.1\|UniProtKB=W5MI33	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000024473.1\|UniProtKB=Q1RL70	Ciona intestinalis	O
BRAFL\|Gene=LOC118417455\|UniProtKB=A0A9J7L9Y7	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC115920244\|UniProtKB=A0A7M7N5K7	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC592806\|UniProtKB=A0A7M7NRP7	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00013270\|UniProtKB=Q9NA71	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00039829\|UniProtKB=A8XYZ1	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00039222\|UniProtKB=A8XX96	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00034678\|UniProtKB=A8XJ83	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00089094\|UniProtKB=B6IJC5	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00117568\|UniProtKB=A0A2A6B6T5	Pristionchus pacificus	O
ANOGA\|EnsemblGenome=AGAP009239\|UniProtKB=A0A1S4H1B2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC030779\|UniProtKB=D6WLA9	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_53583\|UniProtKB=E9GQC6	Daphnia pulex	O
DAPPU\|Gene_ORFName=DAPPUDRAFT_66917\|UniProtKB=E9HX69	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW021616\|UniProtKB=A0A1S4LZG7	Ixodes scapularis	O
NEUCR\|EnsemblGenome=NCU02914\|UniProtKB=Q7SHJ0	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_04093\|UniProtKB=A7EFK2	Sclerotinia sclerotiorum	O
TRIV3\|Gene_ORFName=TVAG_153820\|UniProtKB=A2EPT7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_037010\|UniProtKB=A2FH43	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_271140\|UniProtKB=A2EA83	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_050670\|UniProtKB=A2G368	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_568840\|UniProtKB=A2GKL0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_052280\|UniProtKB=A2G741	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_302450\|UniProtKB=A2EGS0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_424990\|UniProtKB=A2F5E9	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00011374001\|UniProtKB=A0CYA7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00036977001\|UniProtKB=A0CBM7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00011288001\|UniProtKB=A0CXY9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00000715001\|UniProtKB=A0CJN6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00018701001\|UniProtKB=A0DN79	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00032330001\|UniProtKB=A0BU81	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00013276001\|UniProtKB=A0D443	Paramecium tetraurelia	O