PANTHER Gene Information   
Gene Symbol(s): Chek2
Organism: Mus musculus
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Gene Name: Serine_threonine-protein kinase Chk2
Gene ID: MGI:1355321
Protein ID: Q9Z265
Persistent Id: PTN002389592
Alternate Ids:
50883(GeneID) 568935903(GI)
AAH56617(EMBL-CDS) ENSMUSG00000029521(Ensembl)
XM_006535070(refSeq) 2.7.11.1(EC)
MGI:1355321(MGI) CHK2_MOUSE(UniProtKB-ID)
ENSMUST00000066160(Ensembl_TRS) BC056617(EMBL)
Checkpoint kinase 2(Synonym) Chek2(Symbol)
ENSMUSP00000066679(Ensembl_PRO)
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PANTHER Classification
PANTHER Family: OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED (PTHR44167)
PANTHER Subfamily: SERINE_THREONINE-PROTEIN KINASE CHK2 (PTHR44167:SF24)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class: non-receptor serine/threonine protein kinase
Pathway Categories: p53 pathway
   Checkpoint kinase 2
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ribosomal protein S6 kinase activity, DNA-dependent protein kinase activity, ATP binding, histone H2AT120 kinase activity, AMP-activated protein kinase activity, histone H3S57 kinase activity, histone H4S1 kinase activity, histone H3S28 kinase activity, histone H3T45 kinase activity, histone H2AXS139 kinase activity, protein serine kinase activity, protein kinase binding, identical protein binding, protein homodimerization activity, histone H3S10 kinase activity, histone H2BS14 kinase activity, histone H2AS1 kinase activity, protein kinase activity, eukaryotic translation initiation factor 2alpha kinase activity, protein serine/threonine kinase activity, 3-phosphoinositide-dependent protein kinase activity, ubiquitin protein ligase binding, histone H2AS121 kinase activity, metal ion binding, histone H3T3 kinase activity, histone H2BS36 kinase activity, Rho-dependent protein serine/threonine kinase activity, kinase activity, histone H3T11 kinase activity, histone H3T6 kinase activity
GO BP Complete: regulation of protein catabolic process, signal transduction in response to DNA damage, mitotic DNA damage checkpoint signaling, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, protein autophosphorylation, protein phosphorylation, double-strand break repair, cell division, chromatin remodeling, G2/M transition of mitotic cell cycle, mitotic G2 phase, positive regulation of DNA-templated transcription, thymocyte apoptotic process, positive regulation of anoikis, mitotic intra-S DNA damage checkpoint signaling, response to gamma radiation, protein catabolic process, regulation of DNA-templated transcription, intrinsic apoptotic signaling pathway in response to DNA damage, DNA damage response, response to glycoside, DNA damage checkpoint signaling, cellular response to gamma radiation, cellular response to bisphenol A, positive regulation of protein phosphorylation, DNA damage response, signal transduction by p53 class mediator, regulation of autophagosome assembly, negative regulation of DNA damage checkpoint, cellular response to xenobiotic stimulus, peptidyl-serine phosphorylation, protein stabilization, mitotic spindle assembly
GO CC Complete: chromosome, telomeric region, nucleus, PML body, cytoplasm, Golgi apparatus, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Regulation of TP53 Activity through Phosphorylation, Generic Transcription Pathway, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, DNA Double-Strand Break Repair, Gene expression (Transcription), G2/M DNA damage checkpoint, Regulation of TP53 Activity, p53-Independent DNA Damage Response, Transcriptional Regulation by TP53, Regulation of TP53 Activity through Methylation, DNA Double Strand Break Response, Regulation of TP53 Expression and Degradation, p53-Independent G1/S DNA damage checkpoint, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, G1/S DNA Damage Checkpoints, DNA Repair, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, p53-Dependent G1 DNA Damage Response, Stabilization of p53, Cell Cycle Checkpoints, Regulation of TP53 Degradation, Cell Cycle, G2/M Checkpoints, p53-Dependent G1/S DNA damage checkpoint, RNA Polymerase II Transcription

Orthologs