PANTHER Gene Information

Gene Symbol(s):

Kdm2a

Organism:

Mus musculus

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Gene Name:

Lysine-specific demethylase 2A

Gene ID:

MGI:1354736

Protein ID:

P59997

Persistent Id:

PTN000565419

Alternate Ids:

1.14.11.27 {ECO:0000250\|UniProtKB:Q9Y2K7}(EC)	100818178(GI)
Q3U1M5(AltAccession)	NM_001001984(refSeq)
BC057051(EMBL)	Fbl11{ECO:0000250\|UniProtKB:Q9Y2K7}(Synonym)
Kdm2a(Symbol)	KDM2A_MOUSE(UniProtKB-ID)
MGI:1354736(MGI)	225876(GeneID)
BAE33470(EMBL-CDS)
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PANTHER Classification

PANTHER Family:	PHD/F-BOX CONTAINING PROTEIN (PTHR23123)
PANTHER Subfamily:	LYSINE-SPECIFIC DEMETHYLASE 2A (PTHR23123:SF3)
PANTHER GO-slim Molecular Function:	transcription coregulator activity histone demethylase activity
PANTHER GO-slim Biological Process:	protein modification process regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component:
PANTHER protein class:	histone modifying enzyme

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	zinc ion binding, transcription coregulator activity, histone H3K36me/H3K36me2 demethylase activity, histone demethylase activity, unmethylated CpG binding, histone H3K36 demethylase activity
GO BP Complete:	multicellular organism growth, neuroepithelial cell differentiation, transcription initiation-coupled chromatin remodeling, neuron differentiation, double-strand break repair via nonhomologous end joining, regulation of circadian rhythm, regulation of transcription by RNA polymerase II, negative regulation of gene expression, chromatin remodeling, circadian regulation of gene expression, neural tube closure, in utero embryonic development, negative regulation of transcription by competitive promoter binding, positive regulation of gene expression, negative regulation of apoptotic process, heart looping
GO CC Complete:	chromatin, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Chromatin organization, HDMs demethylate histones, Chromatin modifying enzymes

Orthologs

ID	Organism	Type
HUMAN\|HGNC=13606\|UniProtKB=Q9Y2K7	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000050414.1\|UniProtKB=H2Q481	Pan troglodytes	LDO
MACMU\|Ensembl=ENSMMUG00000008771.4\|UniProtKB=A0A5F7ZRZ6	Macaca mulatta	LDO
RAT\|RGD=1309419\|UniProtKB=D3ZTJ7	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000044032.3\|UniProtKB=A0A3Q1M3M3	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000029637.4\|UniProtKB=A0A4X1TBJ5	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000025072.4\|UniProtKB=A0A3Q2L4T3	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000003383.6\|UniProtKB=A0A2I2U1R1	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845011373.1\|UniProtKB=A0A8I3RWG7	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000007767.4\|UniProtKB=F7AXE5	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000005993.3\|UniProtKB=F6WWY3	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010023166.1\|UniProtKB=A0A1D5NW01	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000007630.4\|UniProtKB=G1KGW2	Anolis carolinensis	LDO
XENLA\|Gene=LOC108697539\|UniProtKB=A0A8J1LCC4	Xenopus laevis	O
XENLA\|Gene=kdm2a.L\|UniProtKB=A0A8J0TAI7	Xenopus laevis	LDO
ORYLA\|Ensembl=ENSORLG00000011075.2\|UniProtKB=H2M606	Oryzias latipes	O
DANRE\|Gene=kdm2aa\|UniProtKB=A0A8M2B724	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000003398.2\|UniProtKB=H2LE59	Oryzias latipes	LDO
DANRE\|Gene=kdm2ab\|UniProtKB=A0A8M1PZC6	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000008268.1\|UniProtKB=W5MNT5	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000002765.3\|UniProtKB=F7AHE5	Ciona intestinalis	LDO
CIOIN\|Ensembl=ENSCING00000019168.1\|UniProtKB=H2XR56	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118426751\|UniProtKB=A0A9J7M140	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC574799\|UniProtKB=A0A7M7TG73	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00020821\|UniProtKB=Q95Q98	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG01999\|UniProtKB=A8WRR9	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG19679\|UniProtKB=Q60V67	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00097890\|UniProtKB=A0A2A6C4U3	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00099854\|UniProtKB=A0A8R1YAN5	Pristionchus pacificus	LDO
PRIPA\|EnsemblGenome=WBGene00109372\|UniProtKB=A0A2A6BJ61	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0037659\|UniProtKB=Q9VHH9	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP001895\|UniProtKB=A0A1S4GDW8	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC034732\|UniProtKB=A0A139WGM2	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_308697\|UniProtKB=E9H8R0	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW018631\|UniProtKB=B7PLW8	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG104360\|UniProtKB=T1EDL2	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g242923\|UniProtKB=A7S527	Nematostella vectensis	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_25364\|UniProtKB=A9UZ72	Monosiga brevicollis	LDO
YEAST\|SGD=S000000853\|UniProtKB=P40034	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ADL088W\|UniProtKB=Q75AL5	Eremothecium gossypii	O
CANAL\|CGD=CAL0000196618\|UniProtKB=Q5A847	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_E30393g\|UniProtKB=Q6C423	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_07455\|UniProtKB=Q5AW75	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_2G05970\|UniProtKB=Q4WHB7	Neosartorya fumigata	O
PHANO\|EnsemblGenome=SNOG_15868\|UniProtKB=Q0TX58	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPCC622.16c\|UniProtKB=O94603	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_03664\|UniProtKB=B6K4V0	Schizosaccharomyces japonicus	O
CRYNJ\|Gene_OrderedLocusName=CNG00620\|UniProtKB=P0CO40	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_04522\|UniProtKB=Q4P5U1	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_15521\|UniProtKB=E3KYF1	Puccinia graminis	O
PHYRM\|Gene=H3GUG8_PHYRM\|UniProtKB=H3GUG8	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_06g269400v5\|UniProtKB=A0A2K3DN88	Chlamydomonas reinhardtii	O
SELML\|EnsemblGenome=SELMODRAFT_408434\|UniProtKB=D8R8A1	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_437404\|UniProtKB=D8QQM9	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c9_3630\|UniProtKB=A0A2K1K1U5	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0191s0009\|UniProtKB=A0A2R6W182	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_002300150\|UniProtKB=A0A1Y1I4C0	Klebsormidium nitens	O