PANTHER Gene Information   
Gene Symbol(s): Ercc4
Organism: Mus musculus
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Gene Name: DNA repair endonuclease XPF
Gene ID: MGI:1354163
Protein ID: Q9QZD4
Persistent Id: PTN000015930
Alternate Ids:
AF189285(EMBL) AAF03157(EMBL-CDS)
Ercc4{ECO:0000303|Ref.2,ECO:0000312|MGI:MGI:1354163}(Symbol) ENSMUST00000023206(Ensembl_TRS)
50505(GeneID) DNA excision repair protein ERCC-4(Synonym)
NM_015769(refSeq) ENSMUSP00000023206(Ensembl_PRO)
2896801(GI) 3.1.-.- {ECO:0000250|UniProtKB:Q92889}(EC)
XPF_MOUSE(UniProtKB-ID) MGI:1354163(MGI)
ENSMUSG00000022545(Ensembl) O54810(AltAccession)
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PANTHER Classification
PANTHER Family: DNA REPAIR ENDONUCLEASE XPF (PTHR10150)
PANTHER Subfamily: DNA REPAIR ENDONUCLEASE XPF (PTHR10150:SF0)  
PANTHER GO-slim Molecular Function: DNA endonuclease activity
damaged DNA binding
single-stranded DNA binding
PANTHER GO-slim Biological Process: resolution of meiotic recombination intermediates
double-strand break repair via homologous recombination
nucleotide-excision repair
interstrand cross-link repair
PANTHER GO-slim Cellular Component: nucleotide-excision repair complex
PANTHER protein class: endodeoxyribonuclease
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: DNA binding, identical protein binding, 3' overhang single-stranded DNA endodeoxyribonuclease activity, promoter-specific chromatin binding, TFIID-class transcription factor complex binding, DNA endonuclease activity, damaged DNA binding, single-stranded DNA endodeoxyribonuclease activity, single-stranded DNA binding
GO BP Complete: DNA repair, negative regulation of telomere maintenance via telomere lengthening, negative regulation of protection from non-homologous end joining at telomere, UV protection, nucleotide-excision repair involved in interstrand cross-link repair, double-strand break repair via homologous recombination, resolution of meiotic recombination intermediates, telomere maintenance, nucleotide-excision repair, response to UV, double-strand break repair via nonhomologous end joining, regulation of autophagy, telomeric DNA-containing double minutes formation, cellular response to UV, negative regulation of telomere maintenance
GO CC Complete: nucleotide-excision repair factor 1 complex, chromosome, telomeric region, nucleus, nucleotide-excision repair complex, ERCC4-ERCC1 complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: DNA Repair, Formation of Incision Complex in GG-NER, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homology Directed Repair, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Fanconi Anemia Pathway, Nucleotide Excision Repair, DNA Double-Strand Break Repair, Dual incision in TC-NER, Dual Incision in GG-NER, Global Genome Nucleotide Excision Repair (GG-NER)

Orthologs