PANTHER Gene Information

Gene Symbol(s):

Map4k1

Organism:

Mus musculus

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Gene Name:

Mitogen-activated protein kinase kinase kinase kinase 1

Gene ID:

MGI:1346882

Protein ID:

P70218

Persistent Id:

PTN000685757

Alternate Ids:

BC024832(EMBL)	Hematopoietic progenitor kinase(Synonym)
2.7.11.1 {ECO:0000269\|PubMed:11509653, ECO:0000269\|PubMed:9003777}(EC)	101944153(GI)
Q8R3R0(AltAccession)	NM_008279(refSeq)
ENSMUST00000085835(Ensembl_TRS)	Map4k1(Symbol)
MGI:1346882(MGI)	M4K1_MOUSE(UniProtKB-ID)
ENSMUSG00000037337(Ensembl)	AAH24832(EMBL-CDS)
26411(GeneID)	ENSMUSP00000082995(Ensembl_PRO)
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PANTHER Classification

PANTHER Family:	STERILE20-LIKE KINASE, ISOFORM B-RELATED (PTHR48012)
PANTHER Subfamily:	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 1 (PTHR48012:SF15)
PANTHER GO-slim Molecular Function:	protein serine/threonine kinase activity
PANTHER GO-slim Biological Process:	protein phosphorylation intracellular signal transduction
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	non-receptor serine/threonine protein kinase

Pathway Categories:

Apoptosis signaling pathway

Germinal center kinase related

Gonadotropin-releasing hormone receptor pathway

MAP4Ks

Apoptosis signaling pathway

Germinal center kinase

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	MAP kinase kinase kinase kinase activity, ribosomal protein S6 kinase activity, DNA-dependent protein kinase activity, ATP binding, histone H2AT120 kinase activity, AMP-activated protein kinase activity, histone H3S57 kinase activity, histone H4S1 kinase activity, histone H3S28 kinase activity, histone H3T45 kinase activity, histone H2AXS139 kinase activity, protein serine kinase activity, histone H3S10 kinase activity, histone H2BS14 kinase activity, histone H2AS1 kinase activity, eukaryotic translation initiation factor 2alpha kinase activity, protein serine/threonine kinase activity, 3-phosphoinositide-dependent protein kinase activity, protein binding, histone H2AS121 kinase activity, histone H3T3 kinase activity, histone H2BS36 kinase activity, Rho-dependent protein serine/threonine kinase activity, histone H3T11 kinase activity, histone H3T6 kinase activity
GO BP Complete:	cell population proliferation, chromatin remodeling, protein autophosphorylation, JNK cascade, positive regulation of MAPK cascade, protein phosphorylation, peptidyl-serine phosphorylation, cellular response to phorbol 13-acetate 12-myristate, intracellular signal transduction
GO CC Complete:	cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=6863\|UniProtKB=Q92918	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000010933.5\|UniProtKB=A0A2I3SN46	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000016787.3\|UniProtKB=G3RUC7	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000021630.4\|UniProtKB=A0A1D5R952	Macaca mulatta	LDO
RAT\|RGD=1305463\|UniProtKB=D3Z8I4	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000021145.6\|UniProtKB=A0A3Q1NI20	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000002962.5\|UniProtKB=A0A287AZW8	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000017061.4\|UniProtKB=A0A9L0R0E8	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000000829.6\|UniProtKB=A0A337SHY9	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845004960.1\|UniProtKB=A0A8I3MVZ3	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000013308.4\|UniProtKB=F6YWC5	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000000504.3\|UniProtKB=A0A6I8N549	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010009299.1\|UniProtKB=A0A8V0Y9Q1	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000002195.4\|UniProtKB=H9G673	Anolis carolinensis	LDO
XENLA\|Gene=LOC108698644\|UniProtKB=A0A8J1LII1	Xenopus laevis	LDO
XENTR\|Gene=map4k1\|UniProtKB=A0A8J1ISY1	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000001987.2\|UniProtKB=H2L9D7	Oryzias latipes	LDO
DANRE\|Gene=LOC101883459\|UniProtKB=A0A8M2BKQ4	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000002101.1\|UniProtKB=W5M231	lepisosteus oculatus	O
LEPOC\|Ensembl=ENSLOCG00000014339.1\|UniProtKB=W5NAK4	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000022831.1\|UniProtKB=H2XT45	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000009594.3\|UniProtKB=F7AX97	Ciona intestinalis	O
BRAFL\|Gene=LOC118408897\|UniProtKB=A0A9J7HXF1	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC593505\|UniProtKB=A0A7M7HLU8	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00022603\|UniProtKB=Q23290	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG19019\|UniProtKB=A8XUK9	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00103595\|UniProtKB=A0A2A6CR91	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0263395\|UniProtKB=A1ZBH7	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP010837\|UniProtKB=A0A1S4H5Y2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC002609\|UniProtKB=D6WF74	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_315089\|UniProtKB=E9G8P2	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG181782\|UniProtKB=T1FHB4	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG89573\|UniProtKB=T1G7E4	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g158852\|UniProtKB=A7RHW1	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG51772\|UniProtKB=B3RKU7	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_14676\|UniProtKB=A9USG9	Monosiga brevicollis	O
NEUCR\|EnsemblGenome=NCU02750\|UniProtKB=Q7SGA0	Neurospora crassa	O
CRYNJ\|EnsemblGenome=CNA03940\|UniProtKB=Q5KP75	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_11396\|UniProtKB=A0A0D1C8F7	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_22752\|UniProtKB=H6QVH0	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_20684\|UniProtKB=F4PAY5	Batrachochytrium dendrobatidis	O
YEAST\|SGD=S000001144\|UniProtKB=P38692	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ACL104C\|UniProtKB=Q75CM3	Eremothecium gossypii	O
YARLI\|EnsemblGenome=YALI0_E34001g\|UniProtKB=Q6C3K8	Yarrowia lipolytica	O
YARLI\|EnsemblGenome=YALI0_D07502g\|UniProtKB=Q6C9X8	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_06339\|UniProtKB=Q5AZE1	Emericella nidulans	O
EMENI\|EnsemblGenome=ANIA_05674\|UniProtKB=Q5B1A6	Emericella nidulans	O
NEUCR\|EnsemblGenome=NCU00772\|UniProtKB=V5IQF9	Neurospora crassa	O
SCLS1\|Gene_ORFName=SS1G_12848\|UniProtKB=A7F5H0	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_03929\|UniProtKB=Q0UWD5	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC9G1.09\|UniProtKB=O14305	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_03376\|UniProtKB=B6K427	Schizosaccharomyces japonicus	O
SCHPO\|PomBase=SPBC17F3.02\|UniProtKB=O75011	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_04461\|UniProtKB=B6K6W1	Schizosaccharomyces japonicus	O
SCHPO\|PomBase=SPAC2C4.14c\|UniProtKB=O14047	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_02022\|UniProtKB=B6JZI2	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNE01930\|UniProtKB=Q5KGY3	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNG02850\|UniProtKB=Q5KDT4	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_10496\|UniProtKB=A0A0D1DV51	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_17074\|UniProtKB=E3L2V0	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_13347\|UniProtKB=F4P9H1	Batrachochytrium dendrobatidis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_9934\|UniProtKB=F4NZ13	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_052800\|UniProtKB=C4M3R9	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=EHI_152540\|UniProtKB=C4LSU1	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0292350\|UniProtKB=Q54DC8	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_96158\|UniProtKB=F1A5M5	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0286359\|UniProtKB=O61122	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_92678\|UniProtKB=F0ZVM8	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_19_1610\|UniProtKB=Q4QD48	Leishmania major	O
LEIMA\|EnsemblGenome=LMJF_21_0130\|UniProtKB=Q4QCK2	Leishmania major	O
LEIMA\|EnsemblGenome=LMJF_26_2120\|UniProtKB=Q4Q8Y0	Leishmania major	O
LEIMA\|EnsemblGenome=LMJF_11_0510\|UniProtKB=Q4QH29	Leishmania major	O
TRYB2\|Gene_ORFName=TB927.1.1530\|UniProtKB=Q4GZ66	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb09.160.0920\|UniProtKB=Q38FU6	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb10.61.2330\|UniProtKB=Q388G0	Trypanosoma brucei	O
GIAIC\|Gene_ORFName=GL50803_0016862\|UniProtKB=A0A644EZW7	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_2796\|UniProtKB=A8B738	Giardia intestinalis	O
GIAIC\|Gene_ORFName=GL50803_0014436\|UniProtKB=A0A644F1U9	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_10609\|UniProtKB=A8BP53	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_260050\|UniProtKB=A2E8T8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_108200\|UniProtKB=A2EQE4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_038280\|UniProtKB=A2DXY6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_337440\|UniProtKB=A2EWJ0	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_004100\|UniProtKB=A2E5C4	Trichomonas vaginalis	O
PHYRM\|Gene=H3G5J1_PHYRM\|UniProtKB=H3G5J1	Phytophthora ramorum	O
PHYRM\|Gene=H3GQ34_PHYRM\|UniProtKB=H3GQ34	Phytophthora ramorum	O
PHYRM\|Gene=H3G7Z1_PHYRM\|UniProtKB=H3G7Z1	Phytophthora ramorum	O
AMBTC\|EnsemblGenome=AMTR_s00183p00024730\|UniProtKB=U5CTU4	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_10G00480\|UniProtKB=A0A0K9Q5N2	Zostera marina	O
MUSAM\|EnsemblGenome=Ma04_g30140\|UniProtKB=A0A804IVL2	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_0291151mg\|UniProtKB=A0A0Q3TSR7	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3002G313100\|UniProtKB=C5X9D0	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb322360\|UniProtKB=A0A804QFI8	Zea mays	O
ORYSJ\|EnsemblGenome=Os07g0507300\|UniProtKB=Q7EZ29	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_1g26670v3\|UniProtKB=I1GU46	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0142660\|UniProtKB=F2EFS9	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS2A02G233400\|UniProtKB=A0A3B6AY64	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2D02G232200\|UniProtKB=A0A3B6DEP0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2B02G249900\|UniProtKB=A0A3B6C4T6	Triticum aestivum	O
NELNU\|Gene_ORFName=HUJ06_022475\|UniProtKB=A0A1U8Q8K4	Nelumbo nucifera	O
NELNU\|Gene=LOC104599444\|UniProtKB=A0A1U8ADK1	Nelumbo nucifera	O
SPIOL\|Gene=LOC110798750\|UniProtKB=A0A9R0J1Q9	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr15g0717301\|UniProtKB=A0A251SE59	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C700383140\|UniProtKB=A0A9R1UZL5	Lactuca sativa	O
HELAN\|EnsemblGenome=HanXRQr2_Chr10g0449691\|UniProtKB=A0A251TKZ0	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C500275130\|UniProtKB=A0A9R1VFD8	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a0022642mg\|UniProtKB=A0A022QCH5	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_20616\|UniProtKB=A0A1U8HL01	Capsicum annuum	O
SOLLC\|EnsemblGenome=Solyc07g062940.3\|UniProtKB=A0A3Q7HHG4	Solanum lycopersicum	O
TOBAC\|Gene=LOC107831895\|UniProtKB=A0A1S4DP35	Nicotiana tabacum	O
TOBAC\|Gene=LOC107831610\|UniProtKB=A0A1S4DN75	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi19g00197\|UniProtKB=E0CSG9	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_F01158\|UniProtKB=A0A059BND5	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00082932001\|UniProtKB=A0A078I754	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00033097001\|UniProtKB=A0A078GKP3	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00033323001\|UniProtKB=A0A078GHC7	Brassica napus	O
BRACM\|EnsemblGenome=Bra038106\|UniProtKB=M4FAJ2	Brassica campestris	O
ARATH\|TAIR=locus=2824247\|UniProtKB=F4HPR9	Arabidopsis thaliana	O
BRACM\|EnsemblGenome=Bra027269\|UniProtKB=M4EEQ7	Brassica campestris	O
ARATH\|TAIR=locus=2087130\|UniProtKB=Q9LDN6	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107952087\|UniProtKB=A0A1U8NVE7	Gossypium hirsutum	O
GOSHI\|Gene=LOC107895261\|UniProtKB=A0A1U8ID71	Gossypium hirsutum	O
GOSHI\|Gene=LOC107917937\|UniProtKB=A0A1U8KPD6	Gossypium hirsutum	O
GOSHI\|Gene=LOC107948762\|UniProtKB=A0A1U8NIM5	Gossypium hirsutum	O
GOSHI\|Gene=LOC107917758\|UniProtKB=A0A1U8KPA1	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_031601\|UniProtKB=A0A061F861	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g005298mg\|UniProtKB=A0A067FH72	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_001G397600v3\|UniProtKB=A0A2K2CAZ8	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_011G116300v3\|UniProtKB=U5G045	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_03G106600\|UniProtKB=A0A2C9W8W2	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_15G089100\|UniProtKB=A0A251J4F2	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0762330\|UniProtKB=B9T3W4	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_U025600\|UniProtKB=K7LV78	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_12G226300\|UniProtKB=I1LV29	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_06G238000\|UniProtKB=K7KWZ4	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_13G274500\|UniProtKB=K7M2A2	Glycine max	O
MEDTR\|EnsemblGenome=MTR_2g078740\|UniProtKB=A0A072V9F9	Medicago truncatula	O
JUGRE\|Gene=LOC109013244\|UniProtKB=A0A6P9EL79	Juglans regia	O
JUGRE\|EnsemblGenome=Jr09_14260\|UniProtKB=A0A2I4EUY7	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_4G630560\|UniProtKB=A0A0A0L3D4	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_4G176700\|UniProtKB=A0A251PNJ2	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_406890\|UniProtKB=D8R397	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_117572\|UniProtKB=D8SIJ3	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c1_23810\|UniProtKB=A0A7I4BU55	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c17_14200\|UniProtKB=A0A2K1J3W7	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0133s0001\|UniProtKB=A0A2R6W7L7	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_003390070\|UniProtKB=A0A1Y1IET1	Klebsormidium nitens	O