PANTHER Gene Information   
Gene Symbol(s): Map2k7
Organism: Mus musculus
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Gene Name: Dual specificity mitogen-activated protein kinase kinase 7
Gene ID: MGI:1346871
Protein ID: Q8CE90
Persistent Id: PTN000684780
Alternate Ids:
MGI:1346871(MGI) AK031137(EMBL)
O35720(AltAccession) MP2K7_MOUSE(UniProtKB-ID)
ENSMUSG00000109061(Ensembl) 2789436(GI)
MP2K7(Synonym) AAB63447(EMBL-CDS)
26400(GeneID) CHEMBL4523385(ChEMBL)
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PANTHER Classification
PANTHER Family: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED (PTHR48013)
PANTHER Subfamily: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7 (PTHR48013:SF17)  
PANTHER GO-slim Molecular Function: protein kinase activity
PANTHER GO-slim Biological Process: stress-activated MAPK cascade
PANTHER GO-slim Cellular Component:
PANTHER protein class: non-receptor serine/threonine protein kinase
Pathway Categories: FGF signaling pathway
   Dual specificity mitogen-activated protein kinase kinase 4 and 7
Gonadotropin-releasing hormone receptor pathway
   MKK4/7
EGF receptor signaling pathway
   Dual specificity mitogen-activated protein kinase kinase 4 and 7
Huntington disease
   Mitogen activated protein kinase kinase 7
Apoptosis signaling pathway
   Mitogen activated protein kinase kinase 7
Ras Pathway
   Mitogen activated protein kinase kinase 4/7
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein kinase binding, protein phosphatase binding, JUN kinase kinase activity, magnesium ion binding, ATP binding, protein tyrosine kinase activity, protein binding, MAP kinase kinase activity, MAP kinase activity, molecular function activator activity, mitogen-activated protein kinase kinase kinase binding, protein serine kinase activity, enzyme binding
GO BP Complete: positive regulation of JUN kinase activity, positive regulation of telomere capping, response to osmotic stress, response to wounding, JNK cascade, response to UV, positive regulation of neuron apoptotic process, response to heat, cellular response to osmotic stress, cellular response to lipopolysaccharide, positive regulation of DNA-templated transcription, positive regulation of JNK cascade, positive regulation of protein phosphorylation, apoptotic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of telomere maintenance via telomerase, cellular response to interleukin-1, regulation of motor neuron apoptotic process, positive regulation of telomere maintenance, response to tumor necrosis factor, stress-activated MAPK cascade
GO CC Complete: nucleus, cytoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Immune System, Toll Like Receptor TLR1:TLR2 Cascade, Cellular responses to stimuli, Toll Like Receptor 5 (TLR5) Cascade, Toll-like Receptor Cascades, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Interleukin-17 signaling, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, TRIF(TICAM1)-mediated TLR4 signaling , MAP kinase activation, Cellular Senescence, Oxidative Stress Induced Senescence, MyD88-independent TLR4 cascade , Toll Like Receptor TLR6:TLR2 Cascade, FCERI mediated MAPK activation, Innate Immune System, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, Toll Like Receptor 2 (TLR2) Cascade, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Fc epsilon receptor (FCERI) signaling, Signaling by Interleukins, Toll Like Receptor 7/8 (TLR7/8) Cascade, Cytokine Signaling in Immune system, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Cellular responses to stress

Orthologs