PANTHER Gene Information

Gene Symbol(s):

Uba3

Organism:

Mus musculus

View Gene in Tree


Tree	Reduced Tree

Gene Name:

NEDD8-activating enzyme E1 catalytic subunit

Gene ID:

MGI:1341217

Protein ID:

Q8C878

Persistent Id:

PTN000102133

Alternate Ids:

Q3TG68(AltAccession)	NP_001288787(refSeq)
22200(GeneID)	UBA3_MOUSE(UniProtKB-ID)
Uba3(Symbol)	NEDD8-activating enzyme E1C(Synonym)
MGI:1341217(MGI)	AK168859(EMBL)
ENSMUSG00000030061(Ensembl)	BAB29346(EMBL-CDS)
6.2.1.64 {ECO:0000250\|UniProtKB:Q8TBC4}(EC)	162287057(GI)
Show All

PANTHER Classification

PANTHER Family:	UBIQUITIN-ACTIVATING ENZYME E1 (PTHR10953)
PANTHER Subfamily:	NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT (PTHR10953:SF6)
PANTHER GO-slim Molecular Function:	catalytic activity, acting on a protein thiosulfate sulfurtransferase activity ATP-dependent activity ligase activity, forming carbon-sulfur bonds nucleotidyltransferase activity
PANTHER GO-slim Biological Process:	protein neddylation
PANTHER GO-slim Cellular Component:	cytoplasm nucleus
PANTHER protein class:	ubiquitin-protein ligase

Pathway Categories:

Ubiquitin proteasome pathway

Ubiquitin activating enzyme E1

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	ATP binding, nuclear receptor binding, identical protein binding, protein binding, protein heterodimerization activity, NEDD8 activating enzyme activity, protein-containing complex binding
GO BP Complete:	negative regulation of DNA-templated transcription, endomitotic cell cycle, protein neddylation, regulation of cell cycle, mitotic cell cycle
GO CC Complete:	nucleus, cytoplasm, protein-containing complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Immune System, Innate Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Neddylation, Class I MHC mediated antigen processing & presentation, NIK-->noncanonical NF-kB signaling, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Dectin-1 mediated noncanonical NF-kB signaling, Cytokine Signaling in Immune system, Adaptive Immune System, Metabolism of proteins, Post-translational protein modification, TNFR2 non-canonical NF-kB pathway

Orthologs

ID	Organism	Type
HUMAN\|HGNC=12470\|UniProtKB=Q8TBC4	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000015095.5\|UniProtKB=H2R294	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000003959.3\|UniProtKB=G3QMY7	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000008620.4\|UniProtKB=H9YUH8	Macaca mulatta	LDO
RAT\|RGD=621084\|UniProtKB=Q99MI7	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000015556.6\|UniProtKB=Q0P5I7	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000011506.5\|UniProtKB=A0A5G2QVD2	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000009659.4\|UniProtKB=A0A3Q2I7X7	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000023111.4\|UniProtKB=A0A337S4E0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845010556.1\|UniProtKB=A0A8I3NBH3	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000003622.4\|UniProtKB=F7BMV0	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000000489.4\|UniProtKB=A0A6I8NYJ3	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010020061.1\|UniProtKB=A0A8V0ZJ11	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000015287.4\|UniProtKB=G1KR05	Anolis carolinensis	LDO
XENLA\|Gene=uba3.S\|UniProtKB=Q3B8H8	Xenopus laevis	O
XENLA\|Gene=uba3.L\|UniProtKB=A0A1L8GQ11	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-947291\|UniProtKB=A0A8J0SIX4	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000007945.2\|UniProtKB=H2LV43	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040426-2825\|UniProtKB=Q7ZVX6	Danio rerio	LDO
ORYLA\|Ensembl=ENSORLG00000013554.2\|UniProtKB=H2MEI7	Oryzias latipes	O
LEPOC\|Ensembl=ENSLOCG00000010113.1\|UniProtKB=W5MVG5	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000006095.3\|UniProtKB=F6YX67	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118416033\|UniProtKB=A0A9J7L784	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC587059\|UniProtKB=A0A7M7MZQ8	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00004341\|UniProtKB=Q19360	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00036421\|UniProtKB=A8XPD0	Caenorhabditis briggsae	LDO
DROME\|FlyBase=FBgn0263697\|UniProtKB=Q9V6U8	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP005102\|UniProtKB=Q7Q9Q6	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC004234\|UniProtKB=D7EIA6	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_198149\|UniProtKB=E9GRI0	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW015506\|UniProtKB=B7QNG6	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG106596\|UniProtKB=T1EE36	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g103714\|UniProtKB=A7S3Z1	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG25845\|UniProtKB=B3RWV5	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_34910\|UniProtKB=A9US66	Monosiga brevicollis	LDO
YEAST\|SGD=S000006270\|UniProtKB=Q99344	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ADL333C\|UniProtKB=Q75B99	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000175918\|UniProtKB=A0A1D8PPC6	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_F04147g\|UniProtKB=Q6C2Y1	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_02416\|UniProtKB=Q5BAL4	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_2G13730\|UniProtKB=Q4X0E7	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU02532\|UniProtKB=V5IRG0	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_02960\|UniProtKB=A7ECC1	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_04358\|UniProtKB=Q0UV56	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC24H6.12c\|UniProtKB=Q09765	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_00878\|UniProtKB=B6JWV3	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNC02000\|UniProtKB=Q5KKS5	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_11204\|UniProtKB=A0A0D1DNK3	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_00608\|UniProtKB=E3JQC3	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_20639\|UniProtKB=H6QNT1	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_17926\|UniProtKB=E3L5S4	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_19393\|UniProtKB=F4P2C8	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=CL6EHI_098550\|UniProtKB=C4LXD5	Entamoeba histolytica	LDO
DICDI\|dictyBase=DDB_G0283891\|UniProtKB=Q54QG9	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_148650\|UniProtKB=F0ZBM9	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_01_0710\|UniProtKB=E9AC62	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb09.160.3210\|UniProtKB=Q38F81	Trypanosoma brucei	LDO
GIAIC\|EnsemblGenome=GL50803_4083\|UniProtKB=A8BD12	Giardia intestinalis	O
GIAIC\|EnsemblGenome=GL50803_6288\|UniProtKB=A8BDV8	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_446890\|UniProtKB=A2E8P8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_071600\|UniProtKB=A2D863	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_161040\|UniProtKB=A2E4V9	Trichomonas vaginalis	LDO
PLAF7\|EnsemblGenome=PF3D7_0817000\|UniProtKB=C0H4V1	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00018275001\|UniProtKB=A0DLZ0	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_7506\|UniProtKB=B8C6Q4	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GHW1_PHYRM\|UniProtKB=H3GHW1	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_12g491500v5\|UniProtKB=A0A2K3D239	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00025p00060820\|UniProtKB=W1PXY3	Amborella trichopoda	LDO
MUSAM\|EnsemblGenome=Ma08_g22580\|UniProtKB=A0A804K9L7	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_001063mg\|UniProtKB=K3XGP2	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3003G128300\|UniProtKB=C5XH65	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb332890\|UniProtKB=B4FVB9	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os01g0271500\|UniProtKB=B9EV56	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_2g10270v3\|UniProtKB=I1HEE4	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0256580\|UniProtKB=A0A8I6XTG9	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3A02G187200\|UniProtKB=A0A3B6EEE4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G191000\|UniProtKB=A0A3B6GQ86	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3B02G216600\|UniProtKB=A0A077S011	Triticum aestivum	LDO
NELNU\|Gene_ORFName=HUJ06_020911\|UniProtKB=A0A1U7ZR49	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110800550\|UniProtKB=A0A9R0J7R0	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr16g0739091\|UniProtKB=A0A251RYC7	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C900488510\|UniProtKB=A0A9R1WV85	Lactuca sativa	LDO
CAPAN\|EnsemblGenome=T459_02840\|UniProtKB=A0A1U8EA19	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400008991\|UniProtKB=M1AHZ4	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc01g079840.3\|UniProtKB=A0A3Q7EHK7	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107811436\|UniProtKB=A0A1S4BSS3	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi05g00438\|UniProtKB=D7T6S7	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_H03570\|UniProtKB=A0A059B3M6	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_H03572\|UniProtKB=A0A059B474	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=DARMORV10_C09P57080.1\|UniProtKB=A0A078FNQ7	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra006497\|UniProtKB=M4CQK8	Brassica campestris	O
BRACM\|EnsemblGenome=Bra002219\|UniProtKB=M4CDD8	Brassica campestris	LDO
ARATH\|TAIR=locus=2182172\|UniProtKB=O65041	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107941834\|UniProtKB=A0A1U8MZF2	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_020541\|UniProtKB=A0A061EL40	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g0132241mg\|UniProtKB=A0A067GHG8	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_008G204000v3\|UniProtKB=B9HMN4	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_010G031900v3\|UniProtKB=B9HY52	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_03G182800\|UniProtKB=A0A2C9WAU4	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_15G024600\|UniProtKB=A0A2C9UC39	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0913520\|UniProtKB=B9RTW5	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_17G016000\|UniProtKB=I1MR79	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_07G258000\|UniProtKB=I1KNA2	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_4g131690\|UniProtKB=G7JHZ9	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr07_20310\|UniProtKB=A0A2I4GSJ8	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_3G149920\|UniProtKB=A0A0A0L8U2	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_1G153200\|UniProtKB=M5XVV5	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_174709\|UniProtKB=D8RVM4	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_106904\|UniProtKB=D8S2C6	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c19_5590\|UniProtKB=A0A2K1IXB0	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c21_10350\|UniProtKB=A9TI02	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0032s0081\|UniProtKB=A0A2R6X726	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_001250120\|UniProtKB=A0A1Y1I240	Klebsormidium nitens	LDO
NITMS\|EnsemblGenome=Nmar_1548\|UniProtKB=A9A4Z0	Nitrosopumilus maritimus	O
KORCO\|EnsemblGenome=Kcr_0737\|UniProtKB=B1L4V7	Korarchaeum cryptofilum	O
SACS2\|EnsemblGenome=SSO0298\|UniProtKB=Q980J4	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE1056\|UniProtKB=Q8ZXW7	Pyrobaculum aerophilum	O
METAC\|EnsemblGenome=MA_0255\|UniProtKB=Q8TU19	Methanosarcina acetivorans	O
THEKO\|EnsemblGenome=TK2117\|UniProtKB=Q5JEX2	Thermococcus kodakaraensis	O
SYNY3\|Gene=Q6YRV1_SYNY3\|UniProtKB=Q6YRV1	Synechocystis	O
BACTN\|EnsemblGenome=BT_2649\|UniProtKB=Q8A4F0	Bacteroides thetaiotaomicron	O
CHLAA\|EnsemblGenome=Caur_3492\|UniProtKB=A9W9Z4	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO5178\|UniProtKB=Q9FCL0	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv3116\|UniProtKB=L7N674	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv3206c\|UniProtKB=P9WMN7	Mycobacterium tuberculosis	O
STAA8\|EnsemblGenome=SAOUHSC_02545\|UniProtKB=Q2FVX7	Staphylococcus aureus	O
LISMO\|Gene=Q8Y868_LISMO\|UniProtKB=Q8Y868	Listeria monocytogenes	O
BACSU\|EnsemblGenome=BSU_11700\|UniProtKB=O31619	Bacillus subtilis	O
BACSU\|EnsemblGenome=BSU_14270\|UniProtKB=O31702	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_4723\|UniProtKB=Q816U3	Bacillus cereus	O
BACCR\|EnsemblGenome=BC_2124\|UniProtKB=Q81E67	Bacillus cereus	O
BACCR\|EnsemblGenome=BC_0750\|UniProtKB=Q81HQ4	Bacillus cereus	O
DEIRA\|EnsemblGenome=DR_2269\|UniProtKB=Q9RS58	Deinococcus radiodurans	O
GLOVI\|Gene=Q7NFW2_GLOVI\|UniProtKB=Q7NFW2	Gloeobacter violaceus	O
SYNY3\|Gene=moeB\|UniProtKB=P74344	Synechocystis	O
BACTN\|EnsemblGenome=BT_0648\|UniProtKB=Q8AA17	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB12145\|UniProtKB=Q7UJ43	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_1329\|UniProtKB=O67348	Aquifex aeolicus	O
THEYD\|EnsemblGenome=THEYE_A1987\|UniProtKB=B5YIE5	Thermodesulfovibrio yellowstonii	O
HELPY\|EnsemblGenome=HP_0814\|UniProtKB=O25494	Helicobacter pylori	O
NEIMB\|EnsemblGenome=NMB2062\|UniProtKB=Q9JXG4	Neisseria meningitidis serogroup b	O
GEOSL\|EnsemblGenome=GSU0654\|UniProtKB=Q74FF5	Geobacter sulfurreducens	O
GEOSL\|EnsemblGenome=GSU0907\|UniProtKB=Q74EQ5	Geobacter sulfurreducens	O
GEOSL\|EnsemblGenome=GSU1350\|UniProtKB=Q74DG6	Geobacter sulfurreducens	O
BRADU\|Gene=moeB\|UniProtKB=Q89WC6	Bradyrhizobium diazoefficiens	O
SHEON\|Gene_OrderedLocusName=SO_2443\|UniProtKB=Q8EED9	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_0063\|UniProtKB=Q9KVS6	Vibrio cholerae	O
SALTY\|EnsemblGenome=STM4162\|UniProtKB=Q9L9I9	Salmonella typhimurium	O
YERPE\|Gene_OrderedLocusName=YPO3741\|UniProtKB=A0A2U2GZZ8	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAE77327\|UniProtKB=P30138	Escherichia coli	O
HAEIN\|EnsemblGenome=HI_1449\|UniProtKB=P45211	Haemophilus influenzae	O
SHEON\|Gene_OrderedLocusName=SO_0137\|UniProtKB=Q8EKF6	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_A0618\|UniProtKB=Q9KLX3	Vibrio cholerae	O
PSEAE\|EnsemblGenome=PA4663\|UniProtKB=Q9HVC9	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM0845\|UniProtKB=Q56067	Salmonella typhimurium	O
YERPE\|EnsemblGenome=DBB30_12945\|UniProtKB=A0A384L7T2	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAA35514\|UniProtKB=P12282	Escherichia coli	O
COXBU\|EnsemblGenome=CBU_0876\|UniProtKB=Q83D65	Coxiella burnetii	O
XANCP\|EnsemblGenome=XCC1989\|UniProtKB=Q8P977	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA2103\|UniProtKB=Q9I212	Pseudomonas aeruginosa	O