PANTHER Gene Information   
Gene Symbol(s): Slit2
Organism: Mus musculus
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Gene Name: Slit homolog 2 protein
Gene ID: MGI:1315205
Protein ID: Q9R1B9
Persistent Id: PTN000690526
Alternate Ids:
AC101004(EMBL) Slit2(Symbol)
ENSMUSG00000031558(Ensembl) AAH59267(EMBL-CDS)
NP_848919(refSeq) 45477343(GI)
E9QKB4(AltAccession) ENSMUST00000173107(Ensembl_TRS)
MGI:1315205(MGI) SLIT2_MOUSE(UniProtKB-ID)
SLIT2(Synonym) ENSMUSP00000133840(Ensembl_PRO)
20563(GeneID)
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PANTHER Classification
PANTHER Family: SLIT HOMOLOG (PTHR45836)
PANTHER Subfamily: SLIT HOMOLOG 2 PROTEIN (PTHR45836:SF2)  
PANTHER GO-slim Molecular Function: signaling receptor binding
heparin binding
PANTHER GO-slim Biological Process: axon guidance
chemotaxis
regulation of cell growth
negative regulation of cellular process
PANTHER GO-slim Cellular Component:
PANTHER protein class:
Pathway Categories: Axon guidance mediated by Slit/Robo
   Slit

GO MF Complete: identical protein binding, protein homodimerization activity, GTPase inhibitor activity, heparin binding, chemorepellent activity, laminin-1 binding, signaling receptor binding, extracellular matrix structural constituent, Roundabout binding, protein binding, proteoglycan binding, calcium ion binding, heparan sulfate proteoglycan binding
GO BP Complete: negative chemotaxis, chemorepulsion involved in postnatal olfactory bulb interneuron migration, axon guidance, mammary gland duct morphogenesis, cell migration involved in sprouting angiogenesis, branching morphogenesis of an epithelial tube, mammary duct terminal end bud growth, in utero embryonic development, kidney development, negative regulation of cell growth, axonogenesis, positive regulation of synapse assembly, negative regulation of monocyte chemotaxis, negative regulation of lamellipodium assembly, aortic valve morphogenesis, induction of negative chemotaxis, negative regulation of neutrophil chemotaxis, pulmonary valve morphogenesis, negative regulation of vascular permeability, negative regulation of retinal ganglion cell axon guidance, axon extension involved in axon guidance, negative regulation of gene expression, negative regulation of leukocyte chemotaxis, negative regulation of small GTPase mediated signal transduction, neuron projection extension, dorsal/ventral axon guidance, negative regulation of cell migration, Roundabout signaling pathway, motor neuron axon guidance, negative regulation of cell population proliferation, neuron projection morphogenesis, telencephalon cell migration, olfactory bulb development, corticospinal neuron axon guidance through spinal cord, negative regulation of chemokine-mediated signaling pathway, negative regulation of smooth muscle cell chemotaxis, negative regulation of smooth muscle cell migration, negative regulation of mononuclear cell migration, negative regulation of endothelial cell migration, retinal ganglion cell axon guidance, negative regulation of cellular response to growth factor stimulus, ventricular septum morphogenesis, metanephros development, negative regulation of actin filament polymerization, ureteric bud development, negative regulation of axon extension, negative regulation of protein phosphorylation, positive regulation of apoptotic process, cell-cell adhesion, cellular response to heparin
GO CC Complete: dendrite, extracellular space, cytoplasm, cell body, collagen-containing extracellular matrix, neuronal cell body, cell projection, plasma membrane, axon, cell surface
Reactome Pathways: Nervous system development, Role of ABL in ROBO-SLIT signaling, Axon guidance, Signaling by ROBO receptors, SLIT2:ROBO1 increases RHOA activity, Developmental Biology, Regulation of expression of SLITs and ROBOs