PANTHER Gene Information   
Gene Symbol(s): Itch
Organism: Mus musculus
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Gene Name: E3 ubiquitin-protein ligase Itchy
Gene ID: MGI:1202301
Protein ID: Q8C863
Persistent Id: PTN000134879
Alternate Ids:
MGI:1202301(MGI) 2827198(GI)
O54971(AltAccession) ITCH_MOUSE(UniProtKB-ID)
ENSMUSG00000027598(Ensembl) 2.3.2.26 {ECO:0000269|PubMed:15358865, ECO:0000269|PubMed:16446428, ECO:0000269|PubMed:17592138, ECO:0000269|PubMed:18628966, ECO:0000269|PubMed:20392206, ECO:0000269|PubMed:25632008}(EC)
AF037454(EMBL) BAC33298(EMBL-CDS)
HECT-type E3 ubiquitin transferase Itchy homolog(Synonym) Itch(Symbol)
16396(GeneID)
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PANTHER Classification
PANTHER Family: HECT DOMAIN UBIQUITIN-PROTEIN LIGASE (PTHR11254)
PANTHER Subfamily: E3 UBIQUITIN-PROTEIN LIGASE ITCHY HOMOLOG (PTHR11254:SF66)  
PANTHER GO-slim Molecular Function: ubiquitin protein ligase activity
PANTHER GO-slim Biological Process: proteasome-mediated ubiquitin-dependent protein catabolic process
protein K63-linked ubiquitination
protein K48-linked ubiquitination
PANTHER GO-slim Cellular Component: cytoplasm
PANTHER protein class: ubiquitin-protein ligase
Pathway Categories: Ubiquitin proteasome pathway
   Ubiquitin protein ligase E3
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ubiquitin-protein transferase activity, ubiquitin protein ligase activity, protein binding, arrestin family protein binding, ubiquitin-ubiquitin ligase activity, ribonucleoprotein complex binding, CXCR chemokine receptor binding, ubiquitin-like protein ligase binding, ligase activity
GO BP Complete: protein K29-linked ubiquitination, CD4-positive, alpha-beta T cell proliferation, apoptotic process, defense response to virus, protein autoubiquitination, negative regulation of cytoplasmic pattern recognition receptor signaling pathway, protein K48-linked ubiquitination, negative regulation of NF-kappaB transcription factor activity, protein polyubiquitination, protein catabolic process, positive regulation of protein catabolic process, regulation of protein deubiquitination, negative regulation of JNK cascade, T cell anergy, protein monoubiquitination, ubiquitin-dependent protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of receptor catabolic process, positive regulation of T cell anergy, negative regulation of apoptotic process, innate immune response, protein K63-linked ubiquitination, receptor internalization, protein branched polyubiquitination, negative regulation of CD4-positive, alpha-beta T cell proliferation, negative regulation of defense response to virus, protein ubiquitination
GO CC Complete: plasma membrane, nucleoplasm, early endosome membrane, nucleus, early endosome, ubiquitin ligase complex, cytoplasm, cell cortex, intracellular membrane-bounded organelle, membrane, cytosol, cytoplasmic vesicle, protein-containing complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Immune System, Signaling by Receptor Tyrosine Kinases, Antigen processing: Ubiquitination & Proteasome degradation, Activated NOTCH1 Transmits Signal to the Nucleus, Downregulation of ERBB4 signaling, Class I MHC mediated antigen processing & presentation, Generic Transcription Pathway, NOD1/2 Signaling Pathway, Hedgehog 'on' state, Signaling by Hedgehog, Gene expression (Transcription), RUNX1 regulates transcription of genes involved in differentiation of HSCs, Transcriptional regulation by RUNX1, Hedgehog 'off' state, RIPK1-mediated regulated necrosis, Signaling by ERBB4, Signaling by NOTCH1, Innate Immune System, Signal Transduction, Degradation of GLI1 by the proteasome, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Regulation of necroptotic cell death, Regulated Necrosis, Programmed Cell Death, Signaling by NOTCH, Adaptive Immune System, RNA Polymerase II Transcription

Orthologs