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Gene Symbol(s):
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Smad3
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| Organism: |
Mus musculus |
| View Gene in Tree |
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| Gene Name: |
Mothers against decapentaplegic homolog 3
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| Gene ID: |
MGI:1201674
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| Protein ID: |
Q8BUN5
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| Persistent Id: |
PTN000344669 |
| Alternate Ids: |
| 4630837(GI) |
Q8BX84(AltAccession) |
| Smad3(Symbol) |
ENSMUST00000034973(Ensembl_TRS) |
| ENSMUSG00000032402(Ensembl) |
AB008192(EMBL) |
| Smad3(Synonym) |
BAC38789(EMBL-CDS) |
| MGI:1201674(MGI) |
NM_016769(refSeq) |
| 17127(GeneID) |
SMAD3_MOUSE(UniProtKB-ID) |
| CHEMBL4888441(ChEMBL) |
ENSMUSP00000034973(Ensembl_PRO) |
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Show All
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| GO MF Complete: |
nuclear receptor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, double-stranded DNA binding, transcription cis-regulatory region binding, DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, transcription coactivator binding, bHLH transcription factor binding, DNA-binding transcription factor activity, ubiquitin binding, promoter-specific chromatin binding, DNA-binding transcription factor binding, nuclear glucocorticoid receptor binding, phosphatase binding, protein kinase binding, chromatin DNA binding, zinc ion binding, identical protein binding, protein homodimerization activity, transforming growth factor beta receptor binding, cis-regulatory region sequence-specific DNA binding, DNA-binding transcription repressor activity, chromatin binding, beta-catenin binding, DNA-binding transcription factor activity, RNA polymerase II-specific, transcription corepressor binding, DNA binding, protein binding, ubiquitin protein ligase binding, collagen binding, RNA polymerase II-specific DNA-binding transcription factor binding, DEAD/H-box RNA helicase binding, R-SMAD binding, co-SMAD binding, I-SMAD binding, sterol response element binding, enzyme binding, nuclear mineralocorticoid receptor binding
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| GO BP Complete: |
endoderm development, trophoblast cell migration, negative regulation of cardiac muscle hypertrophy in response to stress, transforming growth factor beta receptor signaling pathway, signal transduction involved in regulation of gene expression, negative regulation of protein catabolic process, JNK cascade, immune system development, activin receptor signaling pathway, skeletal system development, response to hypoxia, immune response, in utero embryonic development, negative regulation of cell growth, positive regulation of DNA-templated transcription, regulation of mitochondrial membrane potential, cellular response to glucose stimulus, apoptotic process, heart looping, transdifferentiation, mesoderm formation, regulation of epithelial cell proliferation, positive regulation of bone mineralization, negative regulation of wound healing, embryonic pattern specification, negative regulation of inflammatory response, positive regulation of positive chemotaxis, SMAD protein signal transduction, positive regulation of canonical Wnt signaling pathway, cell-cell junction organization, pericardium development, negative regulation of lung blood pressure, cellular response to virus, negative regulation of gene expression, cellular response to transforming growth factor beta stimulus, positive regulation of focal adhesion assembly, somitogenesis, positive regulation of stress fiber assembly, response to angiotensin, positive regulation of gene expression, positive regulation of transforming growth factor beta3 production, regulation of binding, release of cytochrome c from mitochondria, regulation of transforming growth factor beta receptor signaling pathway, regulation of striated muscle tissue development, negative regulation of osteoblast proliferation, positive regulation of cell migration, cell population proliferation, positive regulation of nitric oxide biosynthetic process, negative regulation of miRNA transcription, negative regulation of cell population proliferation, T cell activation, extrinsic apoptotic signaling pathway, anatomical structure morphogenesis, positive regulation of miRNA transcription, regulation of transforming growth factor beta2 production, positive regulation of extracellular matrix assembly, positive regulation of transcription by RNA polymerase II, embryonic foregut morphogenesis, nodal signaling pathway, negative regulation of osteoblast differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of epithelial to mesenchymal transition, MAPK cascade, paraxial mesoderm morphogenesis, liver development, osteoblast differentiation, positive regulation of SMAD protein signal transduction, lens fiber cell differentiation, adrenal gland development, regulation of immune response, response to transforming growth factor beta, negative regulation of fat cell differentiation, regulation of DNA-templated transcription, embryonic cranial skeleton morphogenesis, negative regulation of cytosolic calcium ion concentration, osteoblast development, developmental growth, regulation of transcription by RNA polymerase II, gastrulation, thyroid gland development, ureteric bud development, negative regulation of apoptotic process, cell differentiation, positive regulation of chondrocyte differentiation, negative regulation of ossification, protein stabilization, positive regulation of interleukin-1 beta production
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| GO CC Complete: |
SMAD protein complex, nucleus, transcription regulator complex, nuclear inner membrane, cytoplasm, ciliary basal body, heteromeric SMAD protein complex, cytosol, receptor complex, chromatin, plasma membrane, nucleoplasm
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| Reactome Pathways: |
Deubiquitination, Signal Transduction, Signaling by Activin, Signaling by TGFB family members, Generic Transcription Pathway, FOXO-mediated transcription, Gene expression (Transcription), Transcriptional regulation by RUNX3, Downregulation of SMAD2/3:SMAD4 transcriptional activity, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, RUNX3 regulates CDKN1A transcription, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Ub-specific processing proteases, Signaling by NODAL, Signaling by TGF-beta Receptor Complex, FOXO-mediated transcription of cell cycle genes, Downregulation of TGF-beta receptor signaling, Developmental Biology, TGF-beta receptor signaling activates SMADs, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription
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