PANTHER Gene Information   
Gene Symbol(s): Cx3cl1
Organism: Mus musculus
View Gene in Tree
Tree Reduced Tree  
Tree Reduced Tree
Gene Name: Fractalkine
Gene ID: MGI:1097153
Protein ID: O35188
Persistent Id: PTN000387957
Alternate Ids:
ABCD-3 {ECO:0000303|PubMed:10508268}(Synonym) AAD41620(EMBL-CDS)
20312(GeneID) ENSMUSP00000034230(Ensembl_PRO)
NP_033168(refSeq) 342187356(GI)
X3CL1_MOUSE(UniProtKB-ID) O35933(AltAccession)
ENSMUSG00000031778(Ensembl) MGI:1097153(MGI)
ENSMUST00000034230(Ensembl_TRS) AK138574(EMBL)
Cx3cl1{ECO:0000303|PubMed:9479488,ECO:0000312|MGI:MGI:1097153}(Symbol)
Show All

PANTHER Classification
PANTHER Family: SMALL INDUCIBLE CYTOKINE A (PTHR12015)
PANTHER Subfamily: FRACTALKINE (PTHR12015:SF92)  
PANTHER GO-slim Molecular Function: cytokine activity
chemokine receptor binding
PANTHER GO-slim Biological Process: granulocyte migration
positive regulation of GTPase activity
inflammatory response
G protein-coupled receptor signaling pathway
antimicrobial humoral immune response mediated by antimicrobial peptide
positive regulation of cell migration
leukocyte chemotaxis
cytokine-mediated signaling pathway
PANTHER GO-slim Cellular Component: extracellular space
PANTHER protein class: cytokine
Pathway Categories: Inflammation mediated by chemokine and cytokine signaling pathway
   Chemokine
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: CX3C chemokine receptor binding, CCR chemokine receptor binding, chemoattractant activity, CXCR1 chemokine receptor binding, integrin binding, chemokine activity
GO BP Complete: negative regulation of glutamate receptor signaling pathway, positive chemotaxis, negative regulation of interleukin-1 alpha production, positive regulation of I-kappaB phosphorylation, positive regulation of angiogenesis, cell chemotaxis, inflammatory response, wound healing, immune response, lymphocyte chemotaxis, macrophage chemotaxis, eosinophil chemotaxis, positive regulation of neuron projection development, negative regulation of tumor necrosis factor production, positive regulation of microglial cell migration, G protein-coupled receptor signaling pathway, positive regulation of inflammatory response, positive regulation of neuroblast proliferation, negative regulation of microglial cell activation, antimicrobial humoral immune response mediated by antimicrobial peptide, positive regulation of transforming growth factor beta1 production, leukocyte migration involved in inflammatory response, inhibitory postsynaptic potential, positive regulation of actin filament bundle assembly, negative regulation of cell migration, regulation of lipopolysaccharide-mediated signaling pathway, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of cell migration, autocrine signaling, negative regulation of hippocampal neuron apoptotic process, negative regulation of vasoconstriction, positive regulation of cell population proliferation, positive regulation of canonical NF-kappaB signal transduction, cell adhesion, positive regulation of cell adhesion, microglial cell proliferation, extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of transcription by RNA polymerase II, positive regulation of smooth muscle cell proliferation, chemotaxis, response to ischemia, cytokine-mediated signaling pathway, positive regulation of macrophage chemotaxis, cellular response to tumor necrosis factor, angiogenesis involved in wound healing, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of calcium-independent cell-cell adhesion, positive regulation of MAPK cascade, positive regulation of release of sequestered calcium ion into cytosol, microglial cell activation, neuron cellular homeostasis, negative regulation of apoptotic process, chemokine-mediated signaling pathway, neutrophil chemotaxis, cell-cell adhesion, negative regulation of apoptotic signaling pathway, integrin activation
GO CC Complete: extracellular space, perinuclear region of cytoplasm, membrane, cell body, neuronal cell body, extracellular region, cell projection, neuron projection, plasma membrane, cell surface
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: GPCR ligand binding, G alpha (i) signalling events, Chemokine receptors bind chemokines, Signal Transduction, Peptide ligand-binding receptors, GPCR downstream signalling, Class A/1 (Rhodopsin-like receptors), Signaling by GPCR

Orthologs