PANTHER Gene Information   
Gene Symbol(s): Gadd45a
Organism: Mus musculus
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Gene Name: Growth arrest and DNA damage-inducible protein GADD45 alpha
Gene ID: MGI:107799
Protein ID: P48316
Persistent Id: PTN000045627
Alternate Ids:
Gadd45a(Symbol) Gadd45(Synonym)
BC011141(EMBL) ENSMUST00000043098(Ensembl_TRS)
6681149(GI) AAA37656(EMBL-CDS)
ENSMUSP00000044034(Ensembl_PRO) 13197(GeneID)
GA45A_MOUSE(UniProtKB-ID) MGI:107799(MGI)
NM_007836(refSeq) ENSMUSG00000036390(Ensembl)
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PANTHER Classification
PANTHER Family: GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 (PTHR10411)
PANTHER Subfamily: GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 ALPHA (PTHR10411:SF3)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process: regulation of cell cycle
PANTHER GO-slim Cellular Component: cytoplasm
nucleus
PANTHER protein class:
Pathway Categories: p53 pathway
   Growth arrest and DNA-damage-inducible, alpha
p53 pathway
   Growth arrest and DNA-damage-inducible, alpha
PI3 kinase pathway
   GADD45
p38 MAPK pathway
   Growth arrest and DNA damage-inducible gene
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein binding, protein homodimerization activity, promoter-specific chromatin binding, protein heterodimerization activity, kinase binding
GO BP Complete: negative regulation of peptidyl-serine phosphorylation of STAT protein, negative regulation of angiogenesis, negative regulation of blood vessel endothelial cell migration, centrosome cycle, signal transduction in response to DNA damage, negative regulation of protein kinase activity, positive regulation of p38MAPK cascade, negative regulation of transcription by RNA polymerase II, cellular response to mechanical stimulus, positive regulation of JNK cascade, positive regulation of apoptotic process, cellular response to ionizing radiation, regulation of cell cycle, negative regulation of protein serine/threonine kinase activity, positive regulation of reactive oxygen species metabolic process
GO CC Complete: nucleus, cytoplasm, nuclear speck
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Transcriptional Regulation by TP53, Generic Transcription Pathway, TP53 Regulates Transcription of Cell Cycle Genes, Gene expression (Transcription), RNA Polymerase II Transcription

Orthologs