PANTHER Gene Information   
Gene Symbol(s): Psma2
Organism: Mus musculus
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Gene Name: Proteasome subunit alpha type-2
Gene ID: MGI:104885
Protein ID: P49722
Persistent Id: PTN000174795
Alternate Ids:
AK151883(EMBL) 378792373(GI)
CAA49782(EMBL-CDS) PSA2(Synonym)
ENSMUSG00000015671(Ensembl) 19166(GeneID)
PSA2_MOUSE(UniProtKB-ID) Q6ZWV8(AltAccession)
NM_008944(refSeq) MGI:104885(MGI)
Psma2(Symbol) ENSMUSP00000129767(Ensembl_PRO)
ENSMUST00000170836(Ensembl_TRS)
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PANTHER Classification
PANTHER Family: PROTEASOME SUBUNIT ALPHA/BETA (PTHR11599)
PANTHER Subfamily: PROTEASOME SUBUNIT ALPHA TYPE-2 (PTHR11599:SF16)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process: proteasome-mediated ubiquitin-dependent protein catabolic process
PANTHER GO-slim Cellular Component: proteasome complex
intracellular anatomical structure
PANTHER protein class: protease
Pathway Categories: Parkinson disease
   20S proteasome
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: -
GO BP Complete: proteasome-mediated ubiquitin-dependent protein catabolic process, response to virus, ubiquitin-dependent protein catabolic process
GO CC Complete: nucleus, cytoplasm, proteasome core complex, proteasome core complex, alpha-subunit complex, P-body, cytosol, proteasome complex, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Metabolism of RNA, Deubiquitination, Gene expression (Transcription), Metabolism of amino acids and derivatives, Signaling by the B Cell Receptor (BCR), Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Neutrophil degranulation, GLI3 is processed to GLI3R by the proteasome, Hedgehog 'off' state, Ub-specific processing proteases, TNFR2 non-canonical NF-kB pathway, APC/C:Cdc20 mediated degradation of mitotic proteins, Signaling by WNT, Signal Transduction, Degradation of GLI1 by the proteasome, Cyclin A:Cdk2-associated events at S phase entry, CDK-mediated phosphorylation and removal of Cdc6, Regulation of RAS by GAPs, Mitotic G2-G2/M phases, PTEN Regulation, Regulation of mitotic cell cycle, Mitotic G1 phase and G1/S transition, Stabilization of p53, Signaling by Interleukins, Downstream signaling events of B Cell Receptor (BCR), Cell Cycle, Cellular responses to stress, Ubiquitin-dependent degradation of Cyclin D, Post-translational protein modification, Regulation of RUNX3 expression and activity, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, AUF1 (hnRNP D0) binds and destabilizes mRNA, Transport of small molecules, Generic Transcription Pathway, ABC-family proteins mediated transport, Degradation of beta-catenin by the destruction complex, Activation of NF-kappaB in B cells, CLEC7A (Dectin-1) signaling, Regulation of mRNA stability by proteins that bind AU-rich elements, Dectin-1 mediated noncanonical NF-kB signaling, Transcriptional regulation by RUNX1, PCP/CE pathway, Degradation of AXIN, Regulation of ornithine decarboxylase (ODC), Degradation of DVL, Orc1 removal from chromatin, Regulation of PTEN stability and activity, UCH proteinases, TCR signaling, Synthesis of DNA, Transcriptional regulation by RUNX3, C-type lectin receptors (CLRs), Transcriptional regulation by RUNX2, S Phase, DNA Replication Pre-Initiation, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, G2/M Checkpoints, RNA Polymerase II Transcription, Cellular responses to stimuli, Immune System, KEAP1-NFE2L2 pathway, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A, Regulation of RUNX2 expression and activity, G1/S Transition, Signaling by Hedgehog, PIP3 activates AKT signaling, RAF/MAP kinase cascade, The role of GTSE1 in G2/M progression after G2 checkpoint, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Cellular response to hypoxia, Mitotic Anaphase, APC/C-mediated degradation of cell cycle proteins, p53-Independent DNA Damage Response, Hedgehog ligand biogenesis, SCF(Skp2)-mediated degradation of p27/p21, MAPK6/MAPK4 signaling, Switching of origins to a post-replicative state, TCF dependent signaling in response to WNT, Downstream TCR signaling, Innate Immune System, Beta-catenin independent WNT signaling, M Phase, p53-Independent G1/S DNA damage checkpoint, Antigen processing-Cross presentation, G1/S DNA Damage Checkpoints, Cross-presentation of soluble exogenous antigens (endosomes), Metabolism of polyamines, APC/C:Cdc20 mediated degradation of Securin, Mitotic Metaphase and Anaphase, Cell Cycle Checkpoints, Fc epsilon receptor (FCERI) signaling, Cytokine Signaling in Immune system, Adaptive Immune System, Asymmetric localization of PCP proteins, MAPK family signaling cascades, p53-Dependent G1/S DNA damage checkpoint, Separation of Sister Chromatids, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Hedgehog 'on' state, DNA Replication, Autodegradation of Cdh1 by Cdh1:APC/C, Interleukin-1 signaling, G2/M Transition, Cell Cycle, Mitotic, MAPK1/MAPK3 signaling, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Interleukin-1 family signaling, Cellular response to chemical stress, Intracellular signaling by second messengers, Neddylation, NIK-->noncanonical NF-kB signaling, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, FCERI mediated NF-kB activation, Assembly of the pre-replicative complex, Autodegradation of the E3 ubiquitin ligase COP1, Nuclear events mediated by NFE2L2, p53-Dependent G1 DNA Damage Response, Cyclin E associated events during G1/S transition , Metabolism, Metabolism of proteins

Orthologs