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Gene Symbol(s):
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Nfkbia
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| Organism: |
Mus musculus |
| View Gene in Tree |
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| Gene Name: |
NF-kappa-B inhibitor alpha
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| Gene ID: |
MGI:104741
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| Protein ID: |
Q9Z1E3
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| Persistent Id: |
PTN000651511 |
| Alternate Ids: |
| 74185295(GI) |
NP_035037(refSeq) |
| ENSMUSP00000021413(Ensembl_PRO) |
Ikba(Synonym) |
| BAE30124(EMBL-CDS) |
Q3UB40(AltAccession) |
| IKBA_MOUSE(UniProtKB-ID) |
18035(GeneID) |
| U57524(EMBL) |
Nfkbia(Symbol) |
| ENSMUST00000021413(Ensembl_TRS) |
MGI:104741(MGI) |
| ENSMUSG00000021025(Ensembl) |
CHEMBL1926493(ChEMBL) |
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Show All
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| GO MF Complete: |
NF-kappaB binding, heat shock protein binding, identical protein binding, protein binding, ubiquitin protein ligase binding, transcription regulator inhibitor activity, protein sequestering activity, molecular sequestering activity, nuclear localization sequence binding, enzyme binding, protein-containing complex binding
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| GO BP Complete: |
response to muramyl dipeptide, positive regulation of transcription initiation by RNA polymerase II, negative regulation of canonical NF-kappaB signal transduction, negative regulation of Notch signaling pathway, positive regulation of transcription by RNA polymerase II, negative regulation of transcription by RNA polymerase II, positive regulation of protein metabolic process, positive regulation of DNA-templated transcription, response to exogenous dsRNA, positive regulation of cholesterol efflux, cellular response to biotic stimulus, cellular response to tumor necrosis factor, response to muscle stretch, nucleotide-binding oligomerization domain containing 1 signaling pathway, B cell receptor signaling pathway, negative regulation of myeloid cell differentiation, negative regulation of protein import into nucleus, negative regulation of NF-kappaB transcription factor activity, toll-like receptor 4 signaling pathway, positive regulation of inflammatory response, non-canonical NF-kappaB signal transduction, canonical NF-kappaB signal transduction, regulation of cell population proliferation, tumor necrosis factor-mediated signaling pathway, Notch signaling pathway, nucleotide-binding oligomerization domain containing 2 signaling pathway, protein import into nucleus, regulation of gene expression, lipopolysaccharide-mediated signaling pathway, negative regulation of macrophage derived foam cell differentiation, negative regulation of lipid storage, negative regulation of cholesterol transport, response to lipopolysaccharide, interleukin-1-mediated signaling pathway, cellular response to cytokine stimulus
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| GO CC Complete: |
nucleus, cytoplasm, cytosol, protein-containing complex, I-kappaB/NF-kappaB complex, plasma membrane
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| Reactome Pathways: |
Immune System, Toll Like Receptor TLR1:TLR2 Cascade, ZBP1(DAI) mediated induction of type I IFNs, Toll Like Receptor 5 (TLR5) Cascade, Toll-like Receptor Cascades, Deubiquitination, Toll Like Receptor 9 (TLR9) Cascade, Signaling by the B Cell Receptor (BCR), NF-kB is activated and signals survival, Ub-specific processing proteases, SUMOylation, Innate Immune System, Downstream TCR signaling, Signal Transduction, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, TAK1-dependent IKK and NF-kappa-B activation , DDX58/IFIH1-mediated induction of interferon-alpha/beta, Toll Like Receptor 2 (TLR2) Cascade, Fc epsilon receptor (FCERI) signaling, Signaling by Interleukins, Cytokine Signaling in Immune system, Downstream signaling events of B Cell Receptor (BCR), Toll Like Receptor 3 (TLR3) Cascade, SUMOylation of immune response proteins, Adaptive Immune System, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, TRAF6 mediated NF-kB activation, Toll Like Receptor 4 (TLR4) Cascade, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Cytosolic sensors of pathogen-associated DNA , TRIF(TICAM1)-mediated TLR4 signaling , Activation of NF-kappaB in B cells, Interleukin-1 signaling, CLEC7A (Dectin-1) signaling, p75 NTR receptor-mediated signalling, Death Receptor Signaling, MyD88-independent TLR4 cascade , Toll Like Receptor TLR6:TLR2 Cascade, Interleukin-1 family signaling, TCR signaling, FCERI mediated NF-kB activation, RIP-mediated NFkB activation via ZBP1, C-type lectin receptors (CLRs), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 10 (TLR10) Cascade, Metabolism of proteins, p75NTR signals via NF-kB
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