PANTHER Gene Information   
Gene Symbol(s): H2ax
Organism: Mus musculus
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Gene Name: Histone H2AX
Gene ID: MGI:102688
Protein ID: P27661
Persistent Id: PTN000605107
Alternate Ids:
Hist5-2ax(Synonym) Z35401(EMBL)
ENSMUSG00000049932(Ensembl) 148693632(GI)
15270(GeneID) CAA41099(EMBL-CDS)
ENSMUST00000052686(Ensembl_TRS) ENSMUSP00000051432(Ensembl_PRO)
NP_034566(refSeq) H2ax{ECO:0000312|MGI:MGI:102688}(Symbol)
H2AX_MOUSE(UniProtKB-ID) MGI:102688(MGI)
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PANTHER Classification
PANTHER Family: HISTONE H2A (PTHR23430)
PANTHER Subfamily: HISTONE H2AX (PTHR23430:SF199)  
PANTHER GO-slim Molecular Function: nucleosome binding
chromatin DNA binding
PANTHER GO-slim Biological Process: heterochromatin formation
PANTHER GO-slim Cellular Component: chromatin
nucleus
PANTHER protein class: chromatin/chromatin-binding, or -regulatory protein
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: structural constituent of chromatin, protein binding, histone binding, protein heterodimerization activity, damaged DNA binding, chromatin-protein adaptor activity, enzyme binding
GO BP Complete: protein localization to site of double-strand break, DNA damage checkpoint signaling, DNA repair, meiotic cell cycle, cellular response to gamma radiation, spermatogenesis, heterochromatin formation, cellular senescence, double-strand break repair via homologous recombination, cerebral cortex development, chromatin organization, DNA damage response
GO CC Complete: site of DNA damage, site of double-strand break, nuclear speck, chromosome, nucleosome, chromatin, condensed nuclear chromosome, male germ cell nucleus, nucleoplasm, replication fork, chromosome, telomeric region, XY body, nucleus, centrosome
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Cellular responses to stimuli, Condensation of Prophase Chromosomes, Base-Excision Repair, AP Site Formation, Nucleosome assembly, Homology Directed Repair, Generic Transcription Pathway, Mitotic Prophase, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Nonhomologous End-Joining (NHEJ), DNA Double-Strand Break Repair, Gene expression (Transcription), Base Excision Repair, G2/M DNA damage checkpoint, Chromosome Maintenance, Cell Cycle, Mitotic, DNA Damage/Telomere Stress Induced Senescence, Cellular Senescence, Transcriptional regulation by RUNX1, Recognition and association of DNA glycosylase with site containing an affected purine, Depurination, Cleavage of the damaged purine, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Processing of DNA double-strand break ends, Inhibition of DNA recombination at telomere, DNA Double Strand Break Response, M Phase, PRC2 methylates histones and DNA, Deposition of new CENPA-containing nucleosomes at the centromere, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Epigenetic regulation of gene expression, DNA Repair, Telomere Maintenance, Cell Cycle Checkpoints, Cell Cycle, G2/M Checkpoints, Cellular responses to stress, RNA Polymerase II Transcription

Orthologs