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Browse PANTHER with the Prowler
Evolutionary analysis of coding SNPs Tips

Estimates the likelihood of a particular nonsynonymous (amino-acid changing) coding SNP to cause a functional impact on the protein. It calculates the subPSEC (substitution position-specific evolutionary conservation) score based on an alignment of evolutionarily related proteins, as described in Thomas et al., 2003 and Thomas & Kejariwal, 2004.
 
Enter a protein sequence: Tips
 
Enter substitution(s), e.g. A265V Tips
Submit

NEW! To analyze many SNPs, download the PANTHER Coding Snp Analysis tool from the downloads page.
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