PANTHER - Evolutionary analysis of coding SNPs

Evolutionary analysis of coding SNPs

Estimates the likelihood of a particular nonsynonymous (amino-acid changing) coding SNP to cause a functional impact on the protein. It calculates the length of time (in millions of years) a given amino acid has been preserved in the lineage leading to the protein of interest. The longer the preservation time, the greater the likelihood of functional impact. The method is called PANTHER-PSEP (position-specific evolutionary preservation) and is described in a recent publication. Please cite this publication if you used either the downloadable tool or this web server.

Enter a protein sequence:

Please note that, for technical reasons, the cSNP scoring tool uses data from PANTHER version 9.0 rather than the latest version.

Enter substitution(s), e.g. A10P

Select single organism

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NEW! To analyze many SNPs, download the PANTHER Coding Snp Analysis tool from the downloads page.