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PANTHER Family Information   
Family: GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE (G6PD) (PTHR23429)
Subfamilies: 1
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract:

Glucose-6-phosphate dehydrogenase (EC: 1.1.1.49) (G6PDH) is a ubiquitous protein, present in bacteria and all eukaryotic cell types [PMID:2838391]. The enzyme catalyses the the first step in the pentose pathway, i.e. the conversion of glucose-6-phosphate to gluconolactone 6-phosphate in the presence of NADP, producing NADPH. The ubiquitous expression of the enzyme gives it a major role in the production of NADPH for the many NADPH-mediated reductive processes in all cells [PMID:3393536]. Deficiency of G6PDH is a common genetic abnormality affecting millions of people worldwide. Many sequence variants, most caused by single point mutations, are known, exhibiting a wide variety of phenotypes [PMID:3393536].


InterPro Accession: IPR001282
PANTHER Molecular Function: Oxidoreductase
   Dehydrogenase

PANTHER Biological Process: Carbohydrate metabolism
   Monosaccharide metabolism

Pathway Categories: No pathway information available
Training Sequences: 54
HMM Length 467
Downloads: HMM (HMMER format)

Genes assigned to this Family
  Total Celera FlyBase NCBI
H. sapiens 4 2 0 2
M. musculus 6 3 0 3
R. norvegicus 5 2 0 3
D. melanogaster 2 0 2 0
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