PANTHER - Family Information

PANTHER Family Information

Family:

NUCLEOTIDE KINASE (PTHR23359)

Subfamilies:

PANTHER Links:

Tree MSA

Abstract:

Adenylate kinases (ADK) are phosphotransferases that catalyse the reversible reaction AMP + MgATP = ADP + MgADP an essential reaction for many processes in living cells. Two ADK isozymes have been identified in mammalian cells. These specifically bind AMP and favour binding to ATP over other nucleotide triphosphates (AK1 is cytosolic and AK2 is located in the mitochondria). A third ADK has been identified in bovine heart and human cells [PMID:6088234], this is a mitochondrial GTP:AMP phosphotransferase, also specific for the phosphorylation of AMP, but can only use GTP or ITP as a substrate [PMID:218813]. ADK has also been identified in different bacterial species and in yeast [PMID:1587477]. Two further enzymes are known to be related to the ADK family, i.e. yeast uridine monophosphokinase and slime mold UMP-CMP kinase. Within the ADK family there are several conserved regions, including the ATP-binding domains. One of the most conserved areas includes an Arg residue, whose modification inactivates the enzyme, together with an Asp that resides in the catalytic cleft of the enzyme and participates in a salt bridge.

InterPro Accession:

IPR000850

PANTHER Molecular Function:

Molecular function unclassified

PANTHER Biological Process:

Biological process unclassified

Pathway Categories:

No pathway information available

Training Sequences:

143

HMM Length

227

Downloads:

HMM (HMMER format)

Genes assigned to this Family

	Total	Celera	FlyBase	NCBI
H. sapiens	33	18	0	15
M. musculus	30	13	0	17
R. norvegicus	24	12	0	12
D. melanogaster	6	0	6	0