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PANTHER Subfamily Information   
Subfamily: ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE ALPHA (PTHR22855:SF3)
Family: ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract: This protein is a subunit of the acetyl coenzyme A carboxylase complex (EC: 6.4.1.2). It catalyzes the first step in the synthesis of long-chain fatty acids which involves the carboxylation of acetyl-CoA to malonyl-CoA. The acetyl-CoA carboxylase complex (EC: 6.4.1.2) is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and two non-identical carboxyl transferase subunits (alpha and beta) in a 2:2 association [PMID:1355089]. The reaction involves two steps: Biotin carrier protein + ATP + HCO3- -> Carboxybiotin carrier protein + ADP + Pi Carboxybiotin carrier protein + Acetyl-CoA -> Malonyl-CoA + Biotin carrier protein
InterPro Accession: IPR001095
PANTHER Molecular Function: Ligase
   Other ligase

PANTHER Biological Process: Lipid, fatty acid and steroid metabolism
   Fatty acid metabolism
          Fatty acid biosynthesis

Pathway Categories: No pathway information available
Training Sequences: 15
HMM Length 547
Downloads: HMM (HMMER format)

Genes assigned to this Subfamily
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