Home     Browse     Genes     Families and HMMs     Pathways     Ontologies     Tools     Workspace  
  Search Families     Download HMMs  
 
PANTHER Subfamily Information   
Subfamily: UROPORPHYRINOGEN DECARBOXYLASE (PTHR21091:SF2)
Family: METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract:

This entry represents uroporphyrinogen decarboxylase (HemE), which catalyzes the fifth step in the heme biosynthetic pathway, converting uroporphyrinogen III to coproporphyrinogen III by decarboxylating the four acetate side chains of the substrate [PMID:9564029]. This step takes the pathway toward protoporphyrin IX, a common precursor of both heme and chlorophyll, rather than toward precorrin 2 and its products.

This activity is essential in all organisms, and subnormal activity of URO-D leads to the most common form of porphyria in humans, porphyria cutanea tarda (PCT).


InterPro Accession: IPR006361
PANTHER Molecular Function: Lyase
   Decarboxylase

PANTHER Biological Process: Coenzyme and prosthetic group metabolism
   Porphyrin metabolism

Pathway Categories: Heme biosynthesis
   Uroporphyrinogen decarboxylase
Training Sequences: 31
HMM Length 452
Downloads: HMM (HMMER format)

Genes assigned to this Subfamily
  Total Celera FlyBase NCBI
H. sapiens 2 1 0 1
M. musculus 2 1 0 1
R. norvegicus 2 1 0 1
D. melanogaster 1 0 1 0
About   |   Contact Us   |   System Requirements   |   Privacy Policy   |   Disclaimer
© Copyright 2007 SRI International. All Rights Reserved.