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PANTHER Family Information   
Family: CHORISMATE SYNTHASE (PTHR21085)
Subfamilies: 1
PANTHER Links:
Tree  Multiple Sequence Alignment
Tree  MSA
Abstract: Chorismate synthase (EC: 4.2.3.5) catalyzes the last of the seven steps in the shikimate pathway which is used in prokaryotes, fungi and plants for the biosynthesis of aromatic amino acids. It catalyzes the 1,4-trans elimination of the phosphate group from 5-enolpyruvylshikimate-3-phosphate (EPSP) to form chorismate which can then be used in phenylalanine, tyrosine or tryptophan biosynthesis. Chorismate synthase requires the presence of a reduced flavin mononucleotide (FMNH2 or FADH2) for its activity. Chorismate synthase from various sources shows [PMID:1718979, PMID:1837329] a high degree of sequence conservation. It is a protein of about 360 to 400 amino-acid residues.
InterPro Accession: IPR000453
PANTHER Molecular Function: Synthase and synthetase
   Other synthase/synthetase
Lyase

PANTHER Biological Process: Amino acid metabolism
   Amino acid biosynthesis

Pathway Categories: Chorismate biosynthesis
   Chorismate synthase
Training Sequences: 21
HMM Length 430
Downloads: HMM (HMMER format)

Genes assigned to this Family
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