PANTHER - Family Information

PANTHER Family Information

Family:

RIBOPHORIN I (PTHR21049)

Subfamilies:

PANTHER Links:

Tree MSA

Abstract:

Ribophorin I is an essential subunit of oligosaccharyltransferase (OST), which is also known as dolichyl-diphosphooligosaccharide--protein glycosyltransferase, (EC: 2.4.1.119). OST catalyses the transfer of an oligosaccharide from dolichol pyrophosphate to selected asparagine residues of nascent polypeptides as they are translocated into the lumen of the rough endoplasmic reticulum. Ribophorin I and OST48 are thought to be responsible for OST catalytic activity [PMID:11443278]. Both yeast and mammalian proteins are glycosylated but the sites are not conserved. Glycosylation may contribute towards general solubility but is unlikely to be involved in a specific biochemical function [PMID:7720878]. Most family members are predicted to have a transmembrane helix at the C terminus of this region.

InterPro Accession:

IPR007676

PANTHER Molecular Function:

Transferase